Imperial College London
Alternate

DrAndreBrown

Faculty of Medicine, Institute of Clinical Sciences

Reader in Behavioural Phenomics
 
 
 
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Contact

 

+44 (0)20 3313 8218andre.brown

 
 
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Location

 

4.15BLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Martinez-Miguel:2021:10.1016/j.cmet.2021.08.017,
author = {Martinez-Miguel, VE and Lujan, C and Espie-Caullet, T and Martinez-Martinez, D and Moore, S and Backes, C and Gonzalez, S and Galimov, ER and Brown, AEX and Halic, M and Tomita, K and Rallis, C and von, der Haar T and Cabreiro, F and Bjedov, I},
doi = {10.1016/j.cmet.2021.08.017},
journal = {Cell Metabolism},
pages = {2288--2300.e12},
title = {Increased fidelity of protein synthesis extends lifespan},
url = {http://dx.doi.org/10.1016/j.cmet.2021.08.017},
volume = {33},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiological consequence of having fewer protein synthesis errors during multi-cellular organismal aging is poorly understood. Our phylogenetic analysis of RPS23, a key protein in the ribosomal decoding center, uncovered a lysine residue almost universally conserved across all domains of life, which is replaced by an arginine in a small number of hyperthermophilic archaea. When introduced into eukaryotic RPS23 homologs, this mutation leads to accurate translation, as well as heat shock resistance and longer life, in yeast, worms, and flies. Furthermore, we show that anti-aging drugs such as rapamycin, Torin1, and trametinib reduce translation errors, and that rapamycin extends further organismal longevity in RPS23 hyperaccuracy mutants. This implies a unified mode of action for diverse pharmacological anti-aging therapies. These findings pave the way for identifying novel translation accuracy interventions to improve aging.
AU  - Martinez-Miguel,VE
AU  - Lujan,C
AU  - Espie-Caullet,T
AU  - Martinez-Martinez,D
AU  - Moore,S
AU  - Backes,C
AU  - Gonzalez,S
AU  - Galimov,ER
AU  - Brown,AEX
AU  - Halic,M
AU  - Tomita,K
AU  - Rallis,C
AU  - von,der Haar T
AU  - Cabreiro,F
AU  - Bjedov,I
DO  - 10.1016/j.cmet.2021.08.017
EP  - 2300
PY  - 2021///
SN  - 1550-4131
SP  - 2288
TI  - Increased fidelity of protein synthesis extends lifespan
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2021.08.017
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000716335200005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1550413121004174?via%3Dihub
UR  - http://hdl.handle.net/10044/1/99881
VL  - 33
ER  -
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