Publications
664 results found
Tokaca N, Cui W, Hazell S, et al., 2020, Squamous Non-Small-Cell Lung Cancer Molecularly Reclassified as Transdifferentiated Prostate Cancer Due to Identification of <i>TMPRSS2-ERG</i> Translocation With <i>SOX2</i> Amplification, JCO ONCOLOGY PRACTICE, Vol: 16, Pages: 695-+, ISSN: 2688-1527
Stock CJ, Conti C, Montero-Fernandez Á, et al., 2020, Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype?, Thorax, Vol: 75, Pages: 901-903, ISSN: 0040-6376
The MUC5B promoter variant rs35705950 is associated with idiopathic pulmonary fibrosis (IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined immunohistochemical expression of MUC5B in different interstitial lung disease patterns according to rs35705950 T-allele carriage. We observed increased expression of MUC5B in T-allele carriers in both distal airways and honeycomb cysts in patients with IPF (n=23), but no difference in MUC5B expression according to T-carrier status in the distal airways of patients with idiopathic non-specific interstitial pneumonitis (n=17), in scleroderma-associated non-specific interstitial pneumonitis (n=15) or in control lungs (n=20), suggesting that tissue overexpression in MUC5B rs35705950 T-carriers is specific to IPF.
Feary J, Parfrey H, Burge S, et al., 2020, Interstitial Lung Disease (ILD) in aluminium welders, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Zhang YZ, Brambilla C, Molyneaux PL, et al., 2020, Presence of pleomorphic features but not growth patterns improves prognostic stratification of epithelioid malignant pleural mesothelioma by 2-tier nuclear grade, Histopathology, Vol: 77, Pages: 423-436, ISSN: 0309-0167
AIMS: Nuclear grade has been recently validated as a powerful prognostic tool in epithelioid malignant pleural mesothelioma (E-MPM). In other studies histological parameters including pleomorphic features and growth patterns were also shown to exert prognostic impact. The primary aims of our study are (1) externally validate the prognostic role of pleomorphic features in E-MPM and (2) investigate if evaluating growth pattern in addition to 2-tier nuclear grade improves prognostication. METHODS AND RESULTS: 614 consecutive cases of E-MPM from our institution over a period of 15 years were retrospectively reviewed, of which 51 showed pleomorphic features. E-MPM with pleomorphic features showed significantly worse overall survival compared those without (5.4 months vs 14.7 months). Tumours with predominantly micropapillary pattern showed the worst survival (6.2 months) followed by solid (10.5 months), microcystic (15.3 months), discohesive (16.1 months), trabecular (17.6 months) and tubulo-papillary (18.6 months). Sub-classification of growth patterns into high grade (solid, micropapillary) and low grade (all others) led to good separation of overall survival (10.5 months vs. 18.0 months) but did not predict survival independent of 2-tier nuclear grade. A composite score comprised of growth pattern and 2-tier nuclear grade did not improve prognostication compared with nuclear grade alone. Intra-tumoural heterogeneity in growth patterns is ubiquitous. CONCLUSIONS: Our findings support the incorporation of E-MPM with pleomorphic features in the epithelioid subtype as a highly aggressive variant distinct from 2-tier nuclear grade. E-MPM demonstrates extensive heterogeneity in growth pattern but its evaluation does not offer additional prognostic utility to 2-tier nuclear grade.
Sholl L, Hirsch FR, Hwang D, et al., 2020, The Promises and Challenges of Tumor Mutation Burden as an Immunotherapy Biomarker: A Perspective from the International Association for the Study of Lung Cancer Pathology Committee, JOURNAL OF THORACIC ONCOLOGY, Vol: 15, Pages: 1409-1424, ISSN: 1556-0864
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- Citations: 138
Molyneaux PL, Smith JJ, Saunders P, et al., 2020, Bronchoalveolar lavage is safe and well tolerated in individuals with idiopathic pulmonary fibrosis: an analysis of the PROFILE study, American Journal of Respiratory and Critical Care Medicine, Vol: 203, Pages: 136-139, ISSN: 1073-449X
Raghu G, Remy-Jardin M, Ryerson CJ, et al., 2020, Diagnosis of Hypersensitivity Pneumonitis in Adults An Official ATS/JRS/ALAT Clinical Practice Guideline, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 202, Pages: E36-E69, ISSN: 1073-449X
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- Citations: 366
Nicholson AG, Osborn M, Devaraj A, et al., 2020, COVID-19 related lung pathology: old patterns in new clothing?, Histopathology, Vol: 77, Pages: 169-172, ISSN: 0309-0167
Mercer RM, Wigston C, Banka R, et al., 2020, Management of solitary fibrous tumours of the pleura: a systematic review and meta-analysis, ERJ OPEN RESEARCH, Vol: 6
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- Citations: 5
Hatabu H, Hunninghake GM, Richeldi L, et al., 2020, Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society, LANCET RESPIRATORY MEDICINE, Vol: 8, Pages: 726-737, ISSN: 2213-2600
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- Citations: 214
AbdulJabbar K, Raza SEA, Rosenthal R, et al., 2020, Geospatial immune variability illuminates differential evolution of lung adenocarcinoma., Nat Med, Vol: 26, Pages: 1054-1062
Remarkable progress in molecular analyses has improved our understanding of the evolution of cancer cells toward immune escape1-5. However, the spatial configurations of immune and stromal cells, which may shed light on the evolution of immune escape across tumor geographical locations, remain unaddressed. We integrated multiregion exome and RNA-sequencing (RNA-seq) data with spatial histology mapped by deep learning in 100 patients with non-small cell lung cancer from the TRACERx cohort6. Cancer subclones derived from immune cold regions were more closely related in mutation space, diversifying more recently than subclones from immune hot regions. In TRACERx and in an independent multisample cohort of 970 patients with lung adenocarcinoma, tumors with more than one immune cold region had a higher risk of relapse, independently of tumor size, stage and number of samples per patient. In lung adenocarcinoma, but not lung squamous cell carcinoma, geometrical irregularity and complexity of the cancer-stromal cell interface significantly increased in tumor regions without disruption of antigen presentation. Decreased lymphocyte accumulation in adjacent stroma was observed in tumors with low clonal neoantigen burden. Collectively, immune geospatial variability elucidates tumor ecological constraints that may shape the emergence of immune-evading subclones and aggressive clinical phenotypes.
Chang W-C, Zhang YZ, Lim E, et al., 2020, Prognostic Impact of Histopathologic Features in Pulmonary Invasive Mucinous Adenocarcinomas Proposal for a Pathologic Grading System, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol: 154, Pages: 88-102, ISSN: 0002-9173
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- Citations: 6
Kouranos V, Ward S, Kokosi MA, et al., 2020, Mixed ventilatory defects in pulmonary sarcoidosis: prevalence and clinical features., Chest, Vol: 158, Pages: 2007-2014, ISSN: 0012-3692
BACKGROUND: In cohort studies of pulmonary sarcoidosis, abnormal ventilatory patterns have generally been sub-divided into restrictive and obstructive defects. Mixed ventilatory defects have been largely overlooked in pulmonary sarcoidosis as total lung capacity (TLC) has seldom been taken into account in historical series. RESEARCH QUESTION: We evaluated the prevalence of mixed disease in pulmonary sarcoidosis and its clinical associations. STUDY DESIGN: and Methods: In patients with pulmonary sarcoidosis (n=1110), mixed defects were defined using ATS/ERS criteria. Clinical data, pulmonary function variables and vital status were abstracted from clinical records. Chest radiographs were evaluated independently by two experienced radiologists. RESULTS: The prevalence of a mixed ventilatory defect was 10.4% in the whole cohort, rising to 25.9% in patients with airflow obstruction. When compared to isolated airflow obstruction, mixed defects were associated with lower DLco levels (50.7 ± 16.3 versus 70.8 ± 18.1, p<0.0001), a higher prevalence of chest radiographic stage IV disease (63.5% versus 38.3%, p<0.0001), and higher mortality (HR 2.36; 95% CI 1.34, 4.15; p=0.003). These findings were reproduced in all patient sub-group analyses, including patients with a histologic diagnosis, a clinical diagnosis, incident disease and prevalent disease. INTERPRETATION: Mixed disease is present in approximately 25% of pulmonary sarcoidosis patients with airflow obstruction and is associated with lower DLco levels, a higher prevalence of stage IV disease and higher mortality than seen in a pure obstructive defect. These observations identify a distinct phenotype associated with a mixed ventilatory defect, justifying future studies of its clinical and pathogenetic significance.
Salle FG, Le Stang N, Tirode F, et al., 2020, Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center, JOURNAL OF THORACIC ONCOLOGY, Vol: 15, Pages: 1037-1053, ISSN: 1556-0864
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- Citations: 34
Huang RSP, Smith D, Le CH, et al., 2020, Correlation of ROS1 Immunohistochemistry With <i>ROS1</i> Fusion Status Determined by Fluorescence In Situ Hybridization, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, Vol: 144, Pages: 735-741, ISSN: 0003-9985
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- Citations: 22
Nicholson AG, Sauter JL, Galateau-Salle F, 2020, Is the Deciduoid Variant of Pleural Mesothelioma Significant? Reply, JOURNAL OF THORACIC ONCOLOGY, Vol: 15, Pages: E94-+, ISSN: 1556-0864
Edwards JG, Chansky K, Van Schil P, et al., 2020, The IASLC Lung Cancer Staging Project: Analysis of Resection Margin Status and Proposals for Residual Tumor Descriptors for Non-Small Cell Lung Cancer, JOURNAL OF THEORETICAL BIOLOGY, Vol: 492, Pages: 344-359, ISSN: 0022-5193
Ruffini E, Fang W, Guerrera F, et al., 2020, The International Association for the Study of Lung Cancer Thymic Tumors Staging Project: The Impact of the Eighth Edition of the Union for International Cancer Control and American Joint Committee on Cancer TNM Stage Classification of Thymic Tumors, JOURNAL OF THEORETICAL BIOLOGY, Vol: 492, Pages: 436-447, ISSN: 0022-5193
Travis WD, Dacic S, Wistuba I, et al., 2020, IASLC Multidisciplinary Recommendations for Pathologic Assessment of Lung Cancer Resection Specimens After Neoadjuvant Therapy, JOURNAL OF THORACIC ONCOLOGY, Vol: 15, Pages: 709-740, ISSN: 1556-0864
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- Citations: 156
Leung M, Freidin MB, Freydina D, et al., 2020, Blood-based circulating tumor DNA mutations as a diagnostic and prognostic biomarker for lung cancer, CANCER, Vol: 126, Pages: 1804-1809, ISSN: 0008-543X
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- Citations: 8
Invernizzi R, Barnett J, Rawal B, et al., 2020, Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent, European Respiratory Journal, Vol: 55, Pages: 1-9, ISSN: 0903-1936
Increasing bacterial burden in the lower airways of patients with idiopathic pulmonary fibrosis confers an increased risk of disease progression and mortality. However, it remains unclear whether this increased bacterial burden directly influences progression of fibrosis or simply reflects the magnitude of the underlying disease extent or severity.We prospectively recruited 193 patients who underwent bronchoscopy and received a multidisciplinary diagnosis of idiopathic pulmonary fibrosis. Quantification of the total bacterial burden in bronchoalveolar lavage fluid was performed by 16S rRNA gene qPCR. Imaging was independently evaluated by two readers assigning quantitative scores for extent, severity and topography of radiographic changes and relationship of these features with bacterial burden was assessed.Increased bacterial burden significantly associated with disease progression (hazard ratio 2.1; 95% confidence interval 1.287–3.474; p=0.0028). Multivariate stepwise regression demonstrated no relationship between bacterial burden and radiological features or extent of disease. When specifically considering patients with definite or probable usual interstitial pneumonia there was no difference in bacterial burden between these two groups. Despite a postulated association between pleuroparenchymal fibroelastosis and clinical infection, there was no relationship between either the presence or extent of pleuroparenchymal fibroelastosis and bacterial burden.We demonstrate that bacterial burden in the lower airways is not simply secondary to the extent of the underlying architectural destruction of the lung parenchyma seen in idiopathic pulmonary fibrosis. The independent nature of this association supports a relationship with the underlying pathogenic mechanisms and highlights the urgent need for functional studies.
Lantuejoul S, Sound-Tsao M, Cooper WA, et al., 2020, PD-L1 Testing for Lung Cancer in 2019: Perspective From the IASLC Pathology Committee, JOURNAL OF THORACIC ONCOLOGY, Vol: 15, Pages: 499-519, ISSN: 1556-0864
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- Citations: 179
Williams GH, Nicholson AG, Snead DRJ, et al., 2020, Interobserver Reliability of Programmed Cell Death Ligand-1 Scoring Using the VENTANA PD-L1 (SP263) Assay in NSCLC, 43rd ESMO Congress (ESMO), Publisher: ELSEVIER SCIENCE INC, Pages: 550-555, ISSN: 1556-0864
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- Citations: 11
Perry R, Christidis D, Nicholson AG, et al., 2020, A case report of Adult-onset Still's disease presenting with acute fibrinous and organising pneumonia., JRSM Open, Vol: 11, ISSN: 2054-2704
Adult-onset Still's disease is a rare inflammatory disorder characterised by fever, arthritis and rash. It can present in a number of ways and is associated in 5% of cases with parenchymal lung involvement. We present the case of a 37-year-old man who initially presented with fever, weight loss and pancytopaenia. He gradually deteriorated requiring non-invasive ventilation with a Computerised tomography of his chest showing bilateral nodular infiltrates. An open lung biopsy showed acute fibrinous organising pneumonia, which responded well to corticosteroid treatment. He then re-presented over three years later with a similar systemic illness although with less severe lung involvement. Following extensive further investigations, he was diagnosed with Adult-onset Still's disease fulfilling the Yamaguchi criteria. We feel this case is important due to the rare association of Adult-onset Still's disease and interstitial lung disease. More specifically, we are not aware of any published cases of Adult-onset Still's disease with acute fibrinous organising pneumonia.
Zhang YZ, Brambilla C, Molyneaux PL, et al., 2020, Utility of nuclear grading system in epithelioid malignant pleural mesothelioma in biopsy-heavy setting, The American Journal of Surgical Pathology, Vol: 44, Pages: 347-356, ISSN: 0147-5185
Nuclear grading systems for epithelioid malignant pleural mesothelioma (MPM) have been proposed but it remains uncertain if they could be applied in a biopsy-heavy setting. Using the proposed system, we conducted an independent, external validation study using 563 consecutive cases of epithelioid MPM diagnosed at our institution between 2003 and 2017, of which 87% of patients underwent biopsies only. The median number of sites sampled was 1, with a median maximum tissue dimension of 17 mm (biopsy) and 150 mm (resection). The median overall survival (OS) was 14.7 months. The frequencies of grade I, II, and III tumors were 31% (132/563), 52% (292/563), and 17% (94/563). Grade I tumors were associated with the most favorable median OS (24.7 mo) followed by grades II (12.7 mo) and III (7.2 mo). The 2-tier nuclear grade separated tumors into low grade (19.3 mo) and high grade (8.9 mo). In multivariate analysis, 3-tier nuclear grade, 2-tier nuclear grade, and mitosis-necrosis score predicted OS independent of age, procedural type, solid-predominant growth pattern, necrosis, and atypical mitosis (all P<0.001 except 2-tier nuclear grade, P=0.001). In the scenario of a single- site biopsy with tissue dimension ≤10 mm, none but age (P=0.002) were independently predictive. Our data also suggested sampling 3 sites or a maximum tissue dimension of at least 20 mm from a single site is optimal for nuclear grade assessment. In conclusion our study confirmed the utility of nuclear grade in epithelioid MPM using a biopsy-heavy cohort provided the tissue sample met minimum dimensional criteria.
Fabre A, Nicholson AG, 2020, Nintedanib in Progressive Fibrosing Interstitial Lung Diseases, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 382, Pages: 780-780, ISSN: 0028-4793
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- Citations: 5
Williams A, Kelleher WP, Nicholson AG, et al., 2020, Diffuse granulomatous disease: looking inside and outside the lungs, Thorax, Vol: 75, Pages: 189-191, ISSN: 0040-6376
Cunningham S, Graham C, MacLean M, et al., 2020, One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD), THORAX, Vol: 75, Pages: 172-175, ISSN: 0040-6376
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- Citations: 7
Marchevsky AM, Khoor A, Walts AE, et al., 2020, Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel, MODERN PATHOLOGY, Vol: 33, Pages: 281-296, ISSN: 0893-3952
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- Citations: 26
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