Imperial College London
Portrait Picture

Dr Andrew Phillips

Faculty of Engineering, Department of Civil and Environmental Engineering

Reader in Structural Biomechanics
 
 
 
//

Contact

 

+44 (0)20 7594 6081andrew.phillips Website

 
 
//

Assistant

 

Ms Ruth Bello +44 (0)20 7594 6040

 
//

Location

 

433Skempton BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@unpublished{Caillet:2021:10.1101/2021.08.05.455188,
author = {Caillet, AHD and Phillips, ATM and Farina, D and Modenese, L},
doi = {10.1101/2021.08.05.455188},
publisher = {Cold Spring Harbor Laboratory},
title = {Mathematical Relationships between Spinal Motoneuron Properties},
url = {http://dx.doi.org/10.1101/2021.08.05.455188},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:p>Our understanding of the behaviour of alpha-motoneurons (MNs) in mammals partly relies on our knowledge of the relationships between MN membrane properties, such as MN size, resistance, rheobase, capacitance, time constant, axonal conduction velocity and afterhyperpolarization period. Based on scattered but converging evidence, current experimental studies and review papers qualitatively assumed that some of these MN properties are related. In this systematic meta-analysis, we reprocessed the data from 40 experimental studies in adult cat, rat and mouse MN preparations in vivo to empirically derive mathematical relations between experimentally measured MN electrophysiological and anatomical properties. These mathematical relationships provide the first validated framework of MN-specific morphometric and electrophysiological properties that reproduce published experimental mammal data in vivo. These relationships moreover support the classic description of a MN as a membrane equivalent electrical circuit and describe for the first time the association between MN size and MN membrane capacitance and time constant. The obtained relationships finally indicate that motor units are recruited in order of increasing MN size, muscle unit size, MN rheobase, unit force recruitment thresholds and tetanic forces, but underlines that MN size and recruitment order may not be related to motor unit type.</jats:p>
AU  - Caillet,AHD
AU  - Phillips,ATM
AU  - Farina,D
AU  - Modenese,L
DO  - 10.1101/2021.08.05.455188
PB  - Cold Spring Harbor Laboratory
PY  - 2021///
TI  - Mathematical Relationships between Spinal Motoneuron Properties
UR  - http://dx.doi.org/10.1101/2021.08.05.455188
ER  -
Download