DrAngelaPinot de Moira

Pinot de Moira A, Taylor-Robinson D, 2023, Social Inequalities in Asthma: The Cold Facts., Arch Bronconeumol, Vol: 59, Pages: 791-792

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Keller A, Groot J, Clippet-Jensen C, de Moira AP, Pedersen M, Sigsgaard T, Loft S, Budtz-Jorgensen E, Andersen A-MNet al., 2023, Exposure to different residential indoor characteristics during childhood and asthma in adolescence: a latent class analysis of the Danish National Birth Cohort, EUROPEAN JOURNAL OF EPIDEMIOLOGY, ISSN: 0393-2990

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Cadman T, Elhakeem A, Vinther JL, Avraam D, Carrasco P, Calas L, Cardo M, Charles M-A, Corpeleijn E, Crozier S, de Castro M, Estarlich M, Fernandes A, Fossatti S, Gruszfeld D, Gurlich K, Grote V, Haakma S, Harris JR, Heude B, Huang R-C, Ibarluzea J, Inskip H, Jaddoe V, Koletzko B, Luque V, Manios Y, Moirano G, Moschonis G, Nader J, Nieuwenhuijsen M, Andersen A-MN, McEachen R, de Moira AP, Popovic M, Roumeliotaki T, Salika T, Marina LS, Santos S, Serbert S, Tzorovili E, Vafeiadi M, Verduci E, Vrijheid M, Vrijkotte TGM, Welten M, Wright J, Yang TC, Zugna D, Lawlor Det al., 2023, Associations of Maternal Educational Level, Proximity to Greenspace During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts., Am J Epidemiol

International sharing of cohort data for research is important and challenging. We explored the feasibility of multi-cohort federated analyses by examining associations between three pregnancy exposures (maternal education, exposure to green vegetation and gestational diabetes) with offspring BMI from infancy to 17 years. We used data from 18 cohorts (n=206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13 and 14-17 years. Associations were estimated using linear regression via one-stage IPD meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z-score comparing low with high education age 2-3 years = 0.03 [95% CI 0.00, 0.05], 4-7 years = 0.16 [95% CI 0.14, 0.17], 8-13 years = 0.24 [95% CI 0.22, 0.26]). Gestational diabetes was positively associated with BMI from 8 years (BMI z-score difference = 0.18 [CI 0.12, 0.25]) but not at younger ages; however associations attenuated towards the null when restricted to cohorts which measured GDM via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age one but not at older ages. Opportunities of cross-cohort federated analyses are discussed.

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Pinot De Moira A, Pearce N, Pedersen M, Nybo Andersen A-Met al., 2023, The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 52, Pages: 1231-1242, ISSN: 0300-5771

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Fortier I, Wey TW, Bergeron J, Pinot de Moira A, Nybo-Andersen A-M, Bishop T, Murtagh MJ, Miocevic M, Swertz MA, van Enckevort E, Marcon Y, Mayrhofer MT, Ornelas JP, Sebert S, Santos AC, Rocha A, Wilson RC, Griffith LE, Burton Pet al., 2023, Life course of retrospective harmonization initiatives: key elements to consider, JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, Vol: 14, Pages: 190-198, ISSN: 2040-1744

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Vinther JL, Cadman T, Avraam D, Ekstrom CT, I A Sorensen T, Elhakeem A, Santos AC, Pinot de Moira A, Heude B, Iniguez C, Pizzi C, Simons E, Voerman E, Corpeleijn E, Zariouh F, Santorelli G, Inskip HM, Barros H, Carson J, Harris JR, Nader JL, Ronkainen J, Strandberg-Larsen K, Santa-Marina L, Calas L, Cederkvist L, Popovic M, Charles M-A, Welten M, Vrijheid MJ, Azad M, Subbarao P, Burton P, Mandhane PJ, Huang R-C, Wilson RC, Haakma S, Fernandez-Barres S, Turvey S, Santos S, Tough SC, Sebert S, Moraes TJ, Salika T, Jaddoe VWV, Lawlor DA, Nybo Andersen A-Met al., 2023, Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies, PLOS MEDICINE, Vol: 20, ISSN: 1549-1277

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van Meel ER, Mensink-Bout SM, den Dekker HT, Ahluwalia TS, Annesi-Maesano I, Arshad SH, Baiz N, Barros H, von Berg A, Bisgaard H, Bonnelykke K, Carlsson CJ, Casas M, Chatzi L, Chevrier C, Dalmeijer G, Dezateux C, Duchen K, Eggesbo M, van der Ent C, Fantini M, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, Granell R, Griffiths LJ, Inskip H, Jerzynska J, Karvonen AM, Keil T, Kelleher C, Kogevinas M, Koppen G, Kuehni CE, Lambrechts N, Lau S, Lehmann I, Ludvigsson J, Magnus MC, Melen E, Mehegan J, Mommers M, Andersen A-MN, Nystad W, Pedersen ESL, Pekkanen J, Peltola V, Pike KC, de Moira AP, Pizzi C, Polanska K, Popovic M, Porta D, Roberts G, Santos AC, Schultz ES, Standl M, Sunyer J, Thijs C, Toivonen L, Uphoff E, Usemann J, Vafeidi M, Wright J, de Jongste JC, Jaddoe VWV, Duijts Let al., 2022, Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children, EUROPEAN RESPIRATORY JOURNAL, Vol: 60, ISSN: 0903-1936

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• Citations: 8

Cadman T, Elhakeem A, Vinther JL, Avraam D, Espi PC, Calas L, Cardol M, Charles M-A, Corpeleijn E, Crozier S, de Castro M, Estarlich M, Fernandes A, Fossatti S, Gruszfeld D, Gurlich K, Grote V, Haakma S, Harris JR, Heude B, Huang R-C, Ibarluzea J, Inskip H, Jaddoe V, Koletzko B, Lioret S, Luque V, Manios Y, Moirano G, Moschonis G, Nader J, Nieuwenhuijsen M, Nybo-Andersen A-M, McEachen R, de Moira AP, Popovic M, Salika T, Roumeliotaki T, Marina LS, Santos S, Serbert S, Tzorovili E, Vafeiadi M, Verduci E, Vrijheid M, Welten M, Wright J, Yang TC, Zugna D, Lawlor Det al., 2022, Associations of maternal education, area deprivation, proximity to greenspace during pregnancy and gestational diabetes with Body Mass Index from early childhood to early adulthood: A proof-of-concept federated analysis in seventeen birth cohorts

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>International sharing of cohort data for research is important and challenging. The LifeCycle project aimed to harmonise data across birth cohorts and develop methods for efficient federated analyses of early life stressors on offspring outcomes.</jats:p></jats:sec><jats:sec><jats:title>Aim</jats:title><jats:p>To explore feasibility of federated analyses of associations between four different types of pregnancy exposures (maternal education, area deprivation, proximity to green space and gestational diabetes) with offspring BMI from infancy to 17 years.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We used harmonised exposure and outcome data from 17 cohorts (n=200,650 mother-child pairs) from the EU Child Cohort Network. For each child, we derived BMI at five age periods: (i) 0-1 years, (ii) 2-3, (iii) 4-7, (iv) 8-13 and (v) 14-17 years. Associations were estimated using linear regression via one-stage individual participant data meta-analysis using the federated analysis platform DataSHIELD.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Associations between lower maternal education and higher child BMI emerged from age 4 years and increased with age (difference in BMI z-score comparing low with high education age 0-1 years = 0.02 [95% CI 0.00, 0.03], 2-3 years = 0.01 [CI -0.02, 0.04], 4-7 years = 0.14 [CI 0.13, 0.16], 8-13 years = 0.22 [CI 0.20, 0.24], 14-17 years = 0.20 [CI 0.16, 0.23]). A similar pattern was found for area deprivation. Gestational diabetes was positively associated with BMI from 8 years (8-13 years = 0.17 [CI 0.10, 0.24], 14-17 years = 0.012 [CI -0.13, 0.38]) but not at younger ages. The normalised difference vegetation index measure of maternal proximity to green space was

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Elhakeem A, Taylor AE, Inskip HM, Huang J, Tafflet M, Vinther JL, Asta F, Erkamp JS, Gagliardi L, Guerlich K, Halliday J, Harskamp-van Ginkel MW, He J-R, Jaddoe VWV, Lewis S, Maher GM, Manios Y, Mansell T, McCarthy FP, McDonald SW, Medda E, Nistico L, de Moira AP, Popovic M, Reiss IKM, Rodrigues C, Salika T, Smith A, Stazi MA, Walker C, Wu M, Asvold BO, Barros H, Brescianini S, Burgner D, Chan JKY, Charles M-A, Eriksson JG, Gaillard R, Grote V, Haberg SE, Heude B, Koletzko B, Morton S, Moschonis G, Murray D, O'Mahony D, Porta D, Qiu X, Richiardi L, Rusconi F, Saffery R, Tough SC, Vrijkotte TGM, Nelson SM, Andersen A-MN, Magnus MC, Lawlor DAet al., 2022, Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood, JAMA NETWORK OPEN, Vol: 5, ISSN: 2574-3805

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• Citations: 7

de Moira AP, Strandberg-Larsen K, Bishop T, Pedersen M, Avraam D, Cadman T, Calas L, Casas M, Guillain BDL, Elhakeem A, Esplugues A, Estarlich M, Foong RE, Haakma S, Harris JR, Huang R-C, Inskip H, Lertxundi A, Mensink-Bout SM, Nader JLT, Pizzi C, Popovic M, Salika T, Sunyer J, Van Meel ER, Swertz MA, Jaddoe VWV, Burton P, Duijts L, Andersen A-MNet al., 2022, Associations of early-life pet ownership with asthma and allergic sensitization: A metaanalysis of more than 77,000 children from the EU Child Cohort Network, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 150, Pages: 82-92, ISSN: 0091-6749

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• Citations: 9

Vinther JL, Cadman T, Avraam D, Ekstrøm CT, Sørensen TIA, Elhakeem A, Santos AC, de Moira AP, Heude B, Iñiguez C, Pizzi C, Simons E, Voerman E, Corpeleijn E, Zariouh F, Santorelli G, Inskip HM, Barros H, Carson J, Harris JR, Nader JL, Ronkainen J, Strandberg-Larsen K, SantaMarina L, Calas L, Cederkvist L, Popovic M, Charles M-A, Welten M, Vrijheid M, Azad M, Subbarao P, Burton P, Mandhane PJ, Huang R-C, Wilson RC, Haakma S, Fernández-Barrés S, Turvey S, Santos S, Tough SC, Sebert S, Fenton T, Moraes TJ, Salika T, Jaddoe VWV, Lawlor DA, Andersen A-MNet al., 2022, Gestational age at birth and body size from infancy through adolescence: findings from analyses of individual data on 253,810 singletons in 16 birth cohort studies

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Preterm birth is the leading cause of perinatal morbidity and mortality, and is associated with adverse developmental and long-term health outcomes, including several cardio-metabolic risk factors. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as proxy of prematurity rather than actual length of gestation. We investigated the association of gestational age at birth (GA) with body size from infancy through adolescence.</jats:p></jats:sec><jats:sec><jats:title>Methods and Findings</jats:title><jats:p>We conducted a two-stage Individual Participant Data (IPD) meta-analysis using data from 253,810 mother-children dyads from 16 general population-based cohort studies in Europe, North America and Australasia to estimate the association of GA with standardized Body Mass Index (BMI) and overweight (including obesity) adjusted for confounders. Using a federated analytical tool (DataSHIELD), we fitted linear and logistic regression models in each cohort separately, and combined the regression estimates and standard errors through random-effects study-level meta-analysis providing an overall effect estimate at early infancy (&gt;0.0-0.5 years), late infancy (&gt;0.5-2.0 years), early childhood (&gt;2.0-5.0 years), mid-childhood (&gt;5.0-9.0 years), late childhood (&gt;9.0-14.0 years) and adolescence (&gt;14.0-19.0 years).</jats:p><jats:p>GA was positively associated with BMI in the first decade of life with mean differences in BMI z-score (0.01-0.02) per week of increase in GA, however preterm infants reached similar levels of BMI as term infants by adolescence. The association of GA with risk of overweight revealed a similar pattern of results from late infancy through mid-childhood with an increased odds of

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Taylor K, Elhakeem A, Thorbjornsrud Nader JL, Yang TC, Isaevska E, Richiardi L, Vrijkotte T, Pinot de Moira A, Murray DM, Finn D, Mason D, Wright J, Oddie S, Roeleveld N, Harris JR, Andersen A-MN, Caputo M, Lawlor DAet al., 2021, Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases: A Parental Negative Control Study, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 10

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• Citations: 13

Pinot de Moira A, Haakma S, Strandberg-Larsen K, van Enckevort E, Kooijman M, Cadman T, Cardol M, Corpeleijn E, Crozier S, Duijts L, Elhakeem A, Eriksson JG, Felix JF, Fernandez-Barres S, Foong RE, Forhan A, Grote V, Guerlich K, Heude B, Huang R-C, Jarvelin M-R, Jorgensen AC, Mikkola TM, Nader JLT, Pedersen M, Popovic M, Rautio N, Richiardi L, Ronkainen J, Roumeliotaki T, Salika T, Sebert S, Vinther JL, Voerman E, Vrijheid M, Wright J, Yang TC, Zariouh F, Charles M-A, Inskip H, Jaddoe VWV, Swertz MA, Nybo Andersen A-Met al., 2021, The EU Child Cohort Network's core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 36, Pages: 565-580, ISSN: 0393-2990

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• Citations: 14

Clotworthy A, Dissing AS, Nguyen T-L, Jensen AK, Andersen TO, Bilsteen JF, Elsenburg LK, Keller A, Kusumastuti S, Mathisen J, Mehta A, Pinot de Moira A, Rod MH, Skovdal M, Strandberg-Larsen K, Tapager IW, Varga TV, Vinther JL, Xu T, Hoeyer K, Hulvej Rod Net al., 2021, 'Standing together - at a distance': Documenting changes in mental-health indicators in Denmark during the COVID-19 pandemic, SCANDINAVIAN JOURNAL OF PUBLIC HEALTH, Vol: 49, Pages: 79-87, ISSN: 1403-4948

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• Citations: 37

Groot J, Andersen A-MN, Blegvad C, de Moira AP, Skov Let al., 2020, Prenatal, infantile, and childhood tobacco exposure and risk of pediatric psoriasis in the Danish National Birth Cohort offspring, JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol: 83, Pages: 1625-1632, ISSN: 0190-9622

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• Citations: 8

Jaddoe VWV, Felix JF, Andersen A-MN, Charles M-A, Chatzi L, Corpeleijn E, Donner N, Elhakeem A, Eriksson JG, Foong R, Grote V, Haakma S, Hanson M, Harris JR, Heude B, Huang R-C, Inskip H, Jarvelin M-R, Koletzko B, Lawlor DA, Lindeboom M, McEachan RRC, Mikkola TM, Nader JLT, de Moira AP, Pizzi C, Richiardi L, Sebert S, Schwalber A, Sunyer J, Swertz MA, Vafeiadi M, Vrijheid M, Wright J, Duijts Let al., 2020, The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents, European Journal of Epidemiology, Vol: 35, Pages: 709-724, ISSN: 0393-2990

Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also prov

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Farnell EJ, Tyagi N, Ryan S, Chalmers IW, de Moira AP, Jones FM, Wawrzyniak J, Fitzsimmons CM, Tukahebwa EM, Furnham N, Maizels RM, Dunne DWet al., 2015, Known allergen structures predict <i>Schistosoma</i> <i>mansoni</i> IgE-binding antigens in human infection, FRONTIERS IN IMMUNOLOGY, Vol: 6, ISSN: 1664-3224

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• Citations: 22

Mazigo HD, Dunne DW, Wilson S, Kinung'hi SM, de Moira AP, Jones FM, Morona D, Nuwaha Fet al., 2014, Co-infection with <i>Schistosoma mansoni</i> and Human Immunodeficiency Virus-1 (HIV-1) among residents of fishing villages of north-western Tanzania, PARASITES & VECTORS, Vol: 7, ISSN: 1756-3305

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• Citations: 27

de Moira AP, Fitzsimmons CM, Jones FM, Wilson S, Cahen P, Tukahebwa E, Mpairwe H, Mwatha JK, Bethony JM, Skov PS, Kabatereine NB, Dunne DWet al., 2014, Suppression of Basophil Histamine Release and Other IgE-dependent Responses in Childhood <i>Schistosoma mansoni</i>/hookworm Coinfection, JOURNAL OF INFECTIOUS DISEASES, Vol: 210, Pages: 1198-1206, ISSN: 0022-1899

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• Citations: 11

Silas S, Fitzsimmons CM, Jones FM, de Moira AP, Wawrzyniak J, Tukahebwa EM, Dunne DWet al., 2014, Human IgE responses to different splice variants of <i>Schistosoma</i> <i>mansoni</i> tropomyosin: associations with immunity, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 44, Pages: 381-390, ISSN: 0020-7519

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• Citations: 11

de Moira AP, Sousa-Figueiredo JC, Jones FM, Fitzsimmons CM, Betson M, Kabatereine NB, Stothard JR, Dunne DWet al., 2013, <i>Schistosoma mansoni</i> Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G₄ Responses to Parasite Allergen-Like Proteins, JOURNAL OF INFECTIOUS DISEASES, Vol: 207, Pages: 362-366, ISSN: 0022-1899

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• Citations: 7

de Moira AP, Jones FM, Wilson S, Tukahebwa E, Fitzsimmons CM, Mwatha JK, Bethony JM, Kabatereine NB, Dunne DWet al., 2013, Effects of Treatment on IgE Responses against Parasite Allergen-Like Proteins and Immunity to Reinfection in Childhood Schistosome and Hookworm Coinfections, INFECTION AND IMMUNITY, Vol: 81, Pages: 23-32, ISSN: 0019-9567

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• Citations: 20

Fitzsimmons CM, Jones FM, de Moira AP, Protasio AV, Khalife J, Dickinson HA, Tukahebwa EM, Dunne DWet al., 2012, Progressive Cross-Reactivity in IgE Responses: an Explanation for the Slow Development of Human Immunity to Schistosomiasis?, INFECTION AND IMMUNITY, Vol: 80, Pages: 4264-4270, ISSN: 0019-9567

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• Citations: 36

Mazigo HD, Nuwaha F, Kinung'hi SM, Morona D, de Moira AP, Wilson S, Heukelbach J, Dunne DWet al., 2012, Epidemiology and control of human schistosomiasis in Tanzania, PARASITES & VECTORS, Vol: 5, ISSN: 1756-3305

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• Citations: 93

van Diepen A, Smit CH, van Egmond L, Kabatereine NB, de Moira AP, Dunne DW, Hokke CHet al., 2012, Differential Anti-Glycan Antibody Responses in <i>Schistosoma mansoni</i>-Infected Children and Adults Studied by Shotgun Glycan Microarray, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735

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• Citations: 52

Li L, de Moira P, Power C, 2011, Predicting cardiovascular disease risk factors in midadulthood from childhood body mass index: utility of different cutoffs for childhood body mass index, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 93, Pages: 1204-1211, ISSN: 0002-9165

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• Citations: 33

de Moira AP, Kabatereine NB, Dunne DW, Booth Met al., 2011, UNDERSTANDING ETHNIC DIFFERENCES IN BEHAVIOUR RELATING TO <i>SCHISTOSOMA MANSONI</i> RE-INFECTION AFTER MASS TREATMENT, JOURNAL OF BIOSOCIAL SCIENCE, Vol: 43, Pages: 185-209, ISSN: 0021-9320

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• Citations: 6

de Moira AP, Fulford AJC, Kabatereine NB, Ouma JH, Booth M, Dunne DWet al., 2010, Analysis of Complex Patterns of Human Exposure and Immunity to <i>Schistosomiasis mansoni</i>: The Influence of Age, Sex, Ethnicity and IgE, PLOS NEGLECTED TROPICAL DISEASES, Vol: 4, ISSN: 1935-2735

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• Citations: 65

de Moira AP, Power C, Li L, 2010, Changing Influences on Childhood Obesity: A Study of 2 Generations of the 1958 British Birth Cohort, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 171, Pages: 1289-1298, ISSN: 0002-9262

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• Citations: 34

Li L, Pinot de Moira A, Power C, 2009, Changing influences on childhood obesity: a study of two generations of the 1958 British birth cohort, Journal of Epidemiology &amp; Community Health, Vol: 63, Pages: 27-27, ISSN: 0143-005X

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