Imperial College London
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DrAngelaPinot de Moira

Faculty of Medicine, National Heart & Lung Institute

Research Associate
 
 
 
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Contact

 

angela.roy19

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vinther:2022:10.1101/2022.06.01.22275859,
author = {Vinther, JL and Cadman, T and Avraam, D and Ekstrøm, CT and Sørensen, TIA and Elhakeem, A and Santos, AC and de, Moira AP and Heude, B and Iñiguez, C and Pizzi, C and Simons, E and Voerman, E and Corpeleijn, E and Zariouh, F and Santorelli, G and Inskip, HM and Barros, H and Carson, J and Harris, JR and Nader, JL and Ronkainen, J and Strandberg-Larsen, K and SantaMarina, L and Calas, L and Cederkvist, L and Popovic, M and Charles, M-A and Welten, M and Vrijheid, M and Azad, M and Subbarao, P and Burton, P and Mandhane, PJ and Huang, R-C and Wilson, RC and Haakma, S and Fernández-Barrés, S and Turvey, S and Santos, S and Tough, SC and Sebert, S and Fenton, T and Moraes, TJ and Salika, T and Jaddoe, VWV and Lawlor, DA and Andersen, A-MN},
doi = {10.1101/2022.06.01.22275859},
title = {Gestational age at birth and body size from infancy through adolescence: findings from analyses of individual data on 253,810 singletons in 16 birth cohort studies},
url = {http://dx.doi.org/10.1101/2022.06.01.22275859},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Preterm birth is the leading cause of perinatal morbidity and mortality, and is associated with adverse developmental and long-term health outcomes, including several cardio-metabolic risk factors. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as proxy of prematurity rather than actual length of gestation. We investigated the association of gestational age at birth (GA) with body size from infancy through adolescence.</jats:p></jats:sec><jats:sec><jats:title>Methods and Findings</jats:title><jats:p>We conducted a two-stage Individual Participant Data (IPD) meta-analysis using data from 253,810 mother-children dyads from 16 general population-based cohort studies in Europe, North America and Australasia to estimate the association of GA with standardized Body Mass Index (BMI) and overweight (including obesity) adjusted for confounders. Using a federated analytical tool (DataSHIELD), we fitted linear and logistic regression models in each cohort separately, and combined the regression estimates and standard errors through random-effects study-level meta-analysis providing an overall effect estimate at early infancy (>0.0-0.5 years), late infancy (>0.5-2.0 years), early childhood (>2.0-5.0 years), mid-childhood (>5.0-9.0 years), late childhood (>9.0-14.0 years) and adolescence (>14.0-19.0 years).</jats:p><jats:p>GA was positively associated with BMI in the first decade of life with mean differences in BMI z-score (0.01-0.02) per week of increase in GA, however preterm infants reached similar levels of BMI as term infants by adolescence. The association of GA with risk of overweight revealed a similar pattern of results from late infancy through mid-childhood with an increased odds of
AU  - Vinther,JL
AU  - Cadman,T
AU  - Avraam,D
AU  - Ekstrøm,CT
AU  - Sørensen,TIA
AU  - Elhakeem,A
AU  - Santos,AC
AU  - de,Moira AP
AU  - Heude,B
AU  - Iñiguez,C
AU  - Pizzi,C
AU  - Simons,E
AU  - Voerman,E
AU  - Corpeleijn,E
AU  - Zariouh,F
AU  - Santorelli,G
AU  - Inskip,HM
AU  - Barros,H
AU  - Carson,J
AU  - Harris,JR
AU  - Nader,JL
AU  - Ronkainen,J
AU  - Strandberg-Larsen,K
AU  - SantaMarina,L
AU  - Calas,L
AU  - Cederkvist,L
AU  - Popovic,M
AU  - Charles,M-A
AU  - Welten,M
AU  - Vrijheid,M
AU  - Azad,M
AU  - Subbarao,P
AU  - Burton,P
AU  - Mandhane,PJ
AU  - Huang,R-C
AU  - Wilson,RC
AU  - Haakma,S
AU  - Fernández-Barrés,S
AU  - Turvey,S
AU  - Santos,S
AU  - Tough,SC
AU  - Sebert,S
AU  - Fenton,T
AU  - Moraes,TJ
AU  - Salika,T
AU  - Jaddoe,VWV
AU  - Lawlor,DA
AU  - Andersen,A-MN
DO  - 10.1101/2022.06.01.22275859
PY  - 2022///
TI  - Gestational age at birth and body size from infancy through adolescence: findings from analyses of individual data on 253,810 singletons in 16 birth cohort studies
UR  - http://dx.doi.org/10.1101/2022.06.01.22275859
ER  -
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