Imperial College London
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DrAnitaHall

Faculty of Natural Sciences, Department of Life Sciences

Senior Teaching Fellow
 
 
 
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Contact

 

+44 (0)20 7594 5193anita.hall Website

 
 
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Location

 

206Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brunkhorst:2004:10.1016/j.bbrc.2004.10.078,
author = {Brunkhorst, A and Neuman, T and Hall, A and Arenas, E and Bartfai, T and Hermanson, O and Metsis, M},
doi = {10.1016/j.bbrc.2004.10.078},
journal = {Biochem Biophys Res Commun},
pages = {574--579},
title = {Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity.},
url = {http://dx.doi.org/10.1016/j.bbrc.2004.10.078},
volume = {325},
year = {2004}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The transcription factor TFIID consists of TATA-binding protein (TBP) and TBP-associated factors (TAFs). TAFs are essential for modulation of transcriptional activity but the regulation of TAFs is complex and many important aspects remain unclear. In this study, we have identified and characterized five novel truncated forms of the TFIID subunit TAF4 (TAF(II)135). Analysis of the mouse gene structure revealed that all truncations were the results of alternative splicing and resulted in the loss of domains or parts of domains implicated in TAF4 functional interactions. Results from transcriptional assays showed that several of the TAF4 isoforms exerted dominant negative effects on TAF4 activity in nuclear receptor-mediated transcriptional activation. In addition, alternative TAF4 isoforms could be detected in specific cell types. Our results indicate an additional level of complexity in TAF4-mediated regulation of transcription and suggest context-specific roles for these new TAF4 isoforms in transcriptional regulation in vivo.
AU  - Brunkhorst,A
AU  - Neuman,T
AU  - Hall,A
AU  - Arenas,E
AU  - Bartfai,T
AU  - Hermanson,O
AU  - Metsis,M
DO  - 10.1016/j.bbrc.2004.10.078
EP  - 579
PY  - 2004///
SN  - 0006-291X
SP  - 574
TI  - Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity.
T2  - Biochem Biophys Res Commun
UR  - http://dx.doi.org/10.1016/j.bbrc.2004.10.078
UR  - https://www.ncbi.nlm.nih.gov/pubmed/15530431
VL  - 325
ER  -
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