Imperial College London
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DrAnitaHall

Faculty of Natural Sciences, Department of Life Sciences

Senior Teaching Fellow
 
 
 
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Contact

 

+44 (0)20 7594 5193anita.hall Website

 
 
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Location

 

206Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fruttiger:1999:10.1242/dev.126.3.457,
author = {Fruttiger, M and Karlsson, L and Hall, AC and Abramsson, A and Calver, AR and Boström, H and Willetts, K and Bertold, CH and Heath, JK and Betsholtz, C and Richardson, WD},
doi = {10.1242/dev.126.3.457},
journal = {Development},
pages = {457--467},
title = {Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.},
url = {http://dx.doi.org/10.1242/dev.126.3.457},
volume = {126},
year = {1999}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is a class of oligodendrocyte progenitors, called O-2A progenitors, that is characterized by expression of platelet-derived growth factor &agr;-receptors (PDGFR(&agr;)). It is not known whether all oligodendrocytes are derived from these PDGFRalpha-progenitors or whether a subset(s) of oligodendrocytes develops from a different, PDGFR alpha-negative lineage(s). We investigated the relationship between PDGF and oligodendrogenesis by examining mice that lack either PDGF-A or PDGF-B. PDGF-A null mice had many fewer PDGFR alpha-progenitors than either wild-type or PDGF-B null mice, demonstrating that proliferation of these cells relies heavily (though not exclusively) on PDGF-AA homodimers. PDGF-A-deficient mice also had reduced numbers of oligodendrocytes and a dysmyelinating phenotype (tremor). Not all parts of the central nervous system (CNS) were equally affected in the knockout. For example, there were profound reductions in the numbers of PDGFR alpha-progenitors and oligodendrocytes in the spinal cord and cerebellum, but less severe reductions of both cell types in the medulla. This correlation suggests a close link between PDGFRalpha-progenitors and oligodendrogenesis in most or all parts of the CNS. We also provide evidence that myelin proteolipid protein (PLP/DM-20)-positive cells in the late embryonic brainstem are non-dividing cells, presumably immature oligodendrocytes, and not proliferating precursors.
AU  - Fruttiger,M
AU  - Karlsson,L
AU  - Hall,AC
AU  - Abramsson,A
AU  - Calver,AR
AU  - Boström,H
AU  - Willetts,K
AU  - Bertold,CH
AU  - Heath,JK
AU  - Betsholtz,C
AU  - Richardson,WD
DO  - 10.1242/dev.126.3.457
EP  - 467
PY  - 1999///
SN  - 0950-1991
SP  - 457
TI  - Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.
T2  - Development
UR  - http://dx.doi.org/10.1242/dev.126.3.457
UR  - https://www.ncbi.nlm.nih.gov/pubmed/9876175
VL  - 126
ER  -
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