Professor Anne Lingford-Hughes is Head, Centre for Psychiatry and Professor of Addiction Biology at Imperial College London. She is also a Consultant Psychiatrist with a particular interest in pharmacological treatments of alcohol and opiate addictions at Central North West London NHS Foundation Trust. Her research has focused on using neuroimaging and neuropharmacological challenges to characterize the neurobiology of addiction. She has used positron emission tomography (PET) and fMRI to characterize the dopamine (DRD2, DRD3), opioid (mu), GABA-benzodiazepine (a5 subtype), GABA-B, NK1 receptor systems in a range of substance addictions including alcoholism, cocaine and opiate dependence in the ICCAM protocol as well disordered gambling. More recently she has been exploring how to facilitate successful opiate detoxification in 2 projects: A:using neuroimaging of brain processes (eg mediating reward, cue reactivity) to assess the potential of NK1 antagonism to attenuate any dysregulation & B: a clinical trial to assess the potential of baclofen (GABA-B agonist) in reducing methadone doses during detox. The aim of her research programme is to better understand neurobiology underpinning these disorders to improve treatment.
Professor Anne Lingford-Hughes leads the MRC Addiction Research Clinical Training Programme (MARC) with Prof Colin Drummond, IOPPN, KCL and Prof Matt Hickman, University of Bristol. For events and opportunities associated with MARC see https://www.imperial.ac.uk/medicine/study/mrc-addiction-research-clinical-training/.
Prof Lingford-Hughes is past Hon. General Secretary of the British Association for Psychopharmacology. She co-developed and wrote their guidelines about the pharmacological management of substance misuse and addiction and comorbidity with psychiatric disorders. She has also contributed to NICE guidance regarding pharmacotherapy of opiate detoxification and alcohol misuse and dependence.
She is currently Professional Liaison Officer, British Neuroscience Association, and immediate past Chair of the Academic Faculty of RCPsych.
She graduated in medicine from Oxford University, completed her PhD at Cambridge University, and trained in psychiatry at The Bethlem and Maudsley Hospitals and Institute of Psychiatry.
et al., 2021, A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial., Pharmaceutical Statistics: the Journal of Applied Statistics in the Pharmaceutical Industry, ISSN:1539-1604
et al., 2021, Boosting the diagnostic power of amyloid-β PET using a data-driven spatially informed classifier for decision support, Alzheimer's Research and Therapy, Vol:13, ISSN:1758-9193, Pages:1-12
Herlinger K, Lingford-Hughes A, 2021, Addressing unmet needs in opiate dependence: supporting detoxification and advances in relapse prevention, Bjpsych Advances, Vol:27, ISSN:2056-4678, Pages:362-372