Imperial College London

ProfessorAnneLingford-Hughes

Faculty of MedicineDepartment of Brain Sciences

Chair in Addiction Biology
 
 
 
//

Contact

 

+44 (0)20 7594 8682anne.lingford-hughes Website

 
 
//

Location

 

Commonwealth BuildingHammersmith Campus

//

Summary

 

Summary

Professor Anne Lingford-Hughes is Head, Centre for Psychiatry and Professor of Addiction Biology at Imperial College London. She is also a Consultant Psychiatrist with a particular interest in pharmacological treatments of alcohol and opiate addictions at Central North West London NHS Foundation Trust. Her research has focused on using neuroimaging and neuropharmacological challenges to characterize the neurobiology of addiction. She has used positron emission tomography (PET) and fMRI to characterize the dopamine (DRD2, DRD3), opioid (mu), GABA-benzodiazepine (a5 subtype), GABA-B, NK1 receptor systems in a range of substance addictions including alcoholism, cocaine and opiate dependence in the ICCAM protocol as well disordered gambling. More recently she has been exploring how to facilitate successful opiate detoxification in 2 projects: A:using neuroimaging of brain processes (eg mediating reward, cue reactivity) to assess the potential of NK1 antagonism to attenuate any dysregulation & B: a clinical trial to assess the potential of baclofen (GABA-B agonist) in reducing methadone doses during detox. The aim of her research programme is to better understand neurobiology underpinning these disorders to improve treatment.

Professor Anne Lingford-Hughes leads the MRC Addiction Research Clinical Training Programme (MARC) with Prof Colin Drummond, IOPPN, KCL and Prof Matt Hickman, University of Bristol. For events and opportunities associated with MARC see https://www.imperial.ac.uk/medicine/study/mrc-addiction-research-clinical-training/. 

Prof Lingford-Hughes is past Hon. General Secretary of the British Association for Psychopharmacology. She co-developed and wrote their guidelines about the pharmacological management of substance misuse and addiction and comorbidity with psychiatric disorders. She has also contributed to NICE guidance regarding pharmacotherapy of opiate detoxification and alcohol misuse and dependence. 

She is currently Professional Liaison Officer, British Neuroscience Association, and immediate past Chair of the Academic Faculty of RCPsych.

She graduated in medicine from Oxford University, completed her PhD at Cambridge University, and trained in psychiatry at The Bethlem and Maudsley Hospitals and Institute of Psychiatry.

Publications

Journals

Agunbiade K, Fonville L, McGonigle J, et al., 2022, Alterations in white matter microstructure in alcohol and alcohol-polydrug dependence: Associations with lifetime alcohol and nicotine exposure, Addiction Biology, Vol:27, ISSN:1355-6215

Matthews P, Venkataraman A, Mansur A, et al., 2022, Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s Disease, Science Translational Medicine, ISSN:1946-6234

Ostinelli EG, Smith K, Zangani C, et al., 2022, COVID-19 and substance use disorders: a review of international guidelines for frontline healthcare workers of addiction services, Bmc Psychiatry, Vol:22

Dhital R, Coleman R, Day E, et al., 2022, Service Users' Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists? (Mar, 10.1093/alcalc/agac011, 2022), Alcohol and Alcoholism, ISSN:0735-0414

Conference

Hayes A, McGonigle J, Elliott R, et al., 2022, The Relationship Between Reward and Impulsivity in Substance Dependence: An fMRI Study, ELSEVIER SCIENCE INC, Pages:S103-S103, ISSN:0006-3223

More Publications