Publications
324 results found
Lees R, Williams T, Henderson G, et al., 2010, Interaction between alcohol and opioids in opioid-dependent subjects, ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S73-S74, ISSN: 0924-977X
Lingford-Hughes AR, Watson BJ, Kalk NJ, et al., 2010, Neuropharmacology of addiction and how it informs treatment., British Medical Bulletin, Vol: 96, Pages: 93-110
Tyacke RJ, Lingford-Hughes AR, Reed LJ, et al., 2010, GABAB Receptors in Addiction and Its Treatment., Advances in Pharmacology, Vol: 58, Pages: 373-396
Williams TM, Davies SJC, Taylor LG, et al., 2009, Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: An [<SUP>11</SUP>C]diprenorphine PET study, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 19, Pages: 740-748, ISSN: 0924-977X
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- Citations: 47
Williams TM, Davies SJC, Taylor LG, et al., 2009, Association between opioid receptor availability and anxiety in healthy controls but not in substance dependence, 22nd Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER, Pages: S653-S654, ISSN: 0924-977X
Tyacke RJ, Robinson ESJ, Harris A, et al., 2009, Paradoxical effects of GABA on the in vivo uptake of the partial inverse GABA agonist [3H]Ro15-4513 in rat brain, 22nd Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S276-S277, ISSN: 0924-977X
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- Citations: 2
Watson BJ, Bowsher B, Wilson S, et al., 2009, P.6.a.008 A pilot study of the effectiveness of D-cycloserine during cue-exposure therapy in abstinent alcohol dependent subjects, European Neuropsychopharmacology, Vol: 19, Pages: S640-S640, ISSN: 0924-977X
Immadisetty V, Cant T, Thyarappa P, et al., 2009, Biomarkers for detecting thiamine deficiency – improving confidence and taking a comprehensive history are also important., Alcohol and Alcoholism, Vol: 44
Daniels JZ, Hickman M, Macleod J, et al., 2009, Is socio-economic status in early life associated with drug use? A systematic review of the evidence., Drug and Alcohol Review, Vol: 28, Pages: 142-153
Zammit S, Moore THM, Lingford-Hughes A, et al., 2008, Effects of cannabis use on outcomes of psychotic disorders: systematic review, BRITISH JOURNAL OF PSYCHIATRY, Vol: 193, Pages: 357-363, ISSN: 0007-1250
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- Citations: 194
Williams TM, Davies SJC, Taylor LG, et al., 2008, Can personality traits elucidate the relationship between substance dependence and opioid receptor availability?, 21st Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S536-S536, ISSN: 0924-977X
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- Citations: 2
Hood S, Melichar J, Taylor L, et al., 2008, Noradrenergic function in generalised anxiety disorder (GAD): A single photon emission tomography (SPET) study, 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP), Publisher: CAMBRIDGE UNIV PRESS, Pages: 278-278, ISSN: 1461-1457
Hickman M, Lingford-Hughes A, Bailey C, et al., 2008, Does alcohol increase the risk of overdose death: the need for a translational approach, ADDICTION, Vol: 103, Pages: 1060-1062, ISSN: 0965-2140
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- Citations: 39
Hickman M, Lingford-Hughes A, Bailey C, et al., 2008, Understanding causal pathways: A response to the commentaries, ADDICTION, Vol: 103, Pages: 1067-1068, ISSN: 0965-2140
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- Citations: 1
Daglish MR, Williams TM, Wilson SJ, et al., 2008, Brain dopamine response in human opioid addiction, Br.J.Psychiatry, Vol: 193, Pages: 65-72
BACKGROUND: Drugs of dependence cause dopamine release in the rat striatum. Human neuroimaging studies have shown an increase in dopamine in the equivalent region in response to stimulants and other drugs. AIMS: We tested whether opioids provoke dopamine release and its relationship to the subjective experience. METHOD: In two combined studies 14 heroin addicts on methadone maintenance treatment underwent two positron emission tomography brain scans of the dopamine system using [(11)C]-raclopride following an injection of placebo and either 50 mg intravenous diamorphine or 10 mg subcutaneous hydromorphone in a double-blind, random order design. RESULTS: Both opioids produced marked subjective and physiological effects, but no measurable change in [(11)C]-raclopride binding. CONCLUSIONS: The absence of a dopamine response to opioid agonists contrasts with that found with stimulant drugs and suggests dopamine may not play the same role in addiction to opioids. This questions the role of dopamine in the subjective experience of heroin in opioid addicts
Taylor C, Nash J, Rich A, et al., 2008, Assessment of GABA<sub>A</sub> Benzodiazepine Receptor (GBzR) Sensitivity in Patients with Alcohol Dependence, ALCOHOL AND ALCOHOLISM, Vol: 43, Pages: 614-618, ISSN: 0735-0414
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- Citations: 2
Lingford-Hughes A, 2008, Using 11C-Ro15 4513, a benzodiazepine inverse agonist, as a PET tracer to study the alpha-5 subtype GABA-BDZ in alcoholism, Conference on Alcoholism and Stress - A Framework for Future Treatment Strategies, Publisher: ELSEVIER SCIENCE INC, Pages: 313-313, ISSN: 0741-8329
Nutt D, Lingford-Hughes A, 2008, Addiction: the clinical interface, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 154, Pages: 397-405, ISSN: 0007-1188
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- Citations: 31
Hitsman B, MacKillop J, Lingford-Hughes A, et al., 2008, Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers, PSYCHOPHARMACOLOGY, Vol: 196, Pages: 611-621, ISSN: 0033-3158
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- Citations: 46
Reid AG, Daglish MRC, Kempton MJ, et al., 2008, Reduced thalamic grey matter volume in opioid dependence is influenced by degree of alcohol use: a voxel-based morphometry study, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 22, Pages: 7-10, ISSN: 0269-8811
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- Citations: 24
Clementi N, Lingford-Hughes A, 2008, Addictions and substance misuse, Medicine, Vol: 36, Pages: 422-429
Nutt DJ, Lingford-Hughes AR, 2008, Addiction: the clinical interface., British Journal of Pharmacology, Vol: 154, Pages: 397-405
Garavan H, Lingford-Hughes A, Jones T, et al., 2007, Neuroimaging, Drugs and the Future, Pages: 285-314, ISBN: 9780123706249
Functional neuroimaging techniques, particularly functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and single photon emission tomography (SPET), are well suited to the study of drug addiction-including the mechanisms involved in its effects on the brain. These techniques have contributed much in the past decade or so toward the understanding of this most challenging social issue. But research effort in this area is not commensurate to the importance of the problem. This chapter reviews the application of neuroimaging to the study of drug addiction, beginning with the defining pharmacology and studies of craving before considering the more cognitive aspects. The availability of small imaging systems, particularly for magnetic resonance imaging (MRI), but also increasingly for PET and SPET, and in a few cases for combined MRI/PET, enables noninvasive methodologies to be applied to animal models. The development of PET as a molecular imaging tool is also considered in the chapter. Future developments in MRI, fMRI and their sister technique, magnetic resonance spectroscopy (MRS), are also elaborated in the chapter. Although the vast majority of neuroimaging studies are based on fMRI, PET and SPET, these techniques lack temporal resolution. A brief discussion of this issue is included in the final section of the chapter. © 2007 Elsevier Inc. All rights reserved.
Nutt DJ, Besson M, Wilson SJ, et al., 2007, Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist, Neuropharmacology, Vol: 53, Pages: 810-820
Alcohol produces many subjective and objective effects in man including pleasure, sedation, anxiolysis, plus impaired eye movements and memory. In human volunteers we have used a newly available GABA-A/benzodiazepine receptor inverse agonist that is selective for the alpha5 subtype (a5IA) to evaluate the role of this subtype in mediating these effects of alcohol on the brain. After pre-treatment with a5IA, we found almost complete blockade of the marked impairment caused by alcohol (mean breath concentration 150mg/100ml) of word list learning and partial but non-significant reversal of subjective sedation without effects on other measures such as intoxication, liking, and slowing of eye movements. This action was not due to alterations in alcohol kinetics and so provides the first proof of concept that selectively decreasing GABA-A receptor function at a specific receptor subtype can offset some actions of alcohol in humans. It also supports growing evidence for a key role of the alpha5 subtype in memory. Inverse agonists at other GABA-A receptor subtypes may prove able to reverse other actions of alcohol, and so offer a new approach to understanding the actions of alcohol in the human brain and in the treatment of alcohol related disorders in humans
Williams TM, Lingford-Hughes A, Davies SJC, et al., 2007, Increased opioid receptor binding in early abstinence from dependent opioid and alcohol use and relationship to craving, 20th Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S187-S188, ISSN: 0924-977X
Bailey JE, Papadopoulos A, Lingford-Hughes A, et al., 2007, D-cycloserine and performance under different states of anxiety in healthy volunteers, PSYCHOPHARMACOLOGY, Vol: 193, Pages: 579-585, ISSN: 0033-3158
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- Citations: 28
Hume SP, Lingford-Hughes AR, Nataf V, et al., 2007, Low sensitivity of the positron emission tomography ligand [<SUP>11</SUP>C] diprenorphine to agonist opiates, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 322, Pages: 661-667, ISSN: 0022-3565
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- Citations: 26
Montgomery AJ, Lingford-Hughes AR, Egerton A, et al., 2007, The effect of nicotine on striatal dopamine release in man:: A [<SUP>11</SUP>C]raclopride PET study, SYNAPSE, Vol: 61, Pages: 637-645, ISSN: 0887-4476
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- Citations: 69
Moore THM, Zammit S, Lingford-Hughes A, et al., 2007, Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review, LANCET, Vol: 370, Pages: 319-328, ISSN: 0140-6736
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- Citations: 1510
Williams TM, Daglish MRC, Lingford-Hughes A, et al., 2007, Brain opioid receptor binding in early abstinence from opioid dependence - Positron emission tomography study, BRITISH JOURNAL OF PSYCHIATRY, Vol: 191, Pages: 63-69, ISSN: 0007-1250
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- Citations: 37
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