Publications
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Lingford-Hughes A, Potokar J, Nutt D, 2002, Treating anxiety complicated by substance misuse, Advances in Psychiatric Treatment, Vol: 8, Pages: 107-116, ISSN: 1355-5146
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- Citations: 13
Lingford-Hughes AR, Hume SP, Feeney A, et al., 2002, Imaging the GABA-benzodiazepine receptor subtype containing the a5-subunit in vivo with PET., Journal of Pharmacology and Experimental Therapeutics, Vol: 22, Pages: 878-889
Daglish MR, Weinstein A, Malizia AL, et al., 2001, Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects, Am.J.Psychiatry, Vol: 158, Pages: 1680-1686
OBJECTIVE: The brain circuitry of opiate craving was investigated with positron emission tomography (PET) imaging of regional cerebral blood flow (rCBF). METHOD: Twelve abstinent opiate-dependent subjects listened to audiotaped autobiographical scripts of an episode of craving and a neutral episode while undergoing a PET scan with the tracer [(15)O]H(2)O. Statistical parametric mapping was used to analyze the PET images of rCBF changes. RESULTS: Comparison of the drug-related and neutral stimulus conditions revealed activation of rCBF in the left medial prefrontal and left anterior cingulate cortices and deactivation in the occipital cortex in response to the drug-related stimulus. A further statistical parametric mapping analysis with a subjective rating of craving as a covariate showed a positive association of between craving and rCBF in the left orbitofrontal cortex. CONCLUSIONS: The patterns of cerebral activation reflect the different brain regions mediating the salience of opiate-related stimuli and the subjective experience of craving for opiates
Daglish M, Lingford-Hughes A, Stevenson B, et al., 2001, Mapping neural activation to alcohol cues in abstinent alcoholics - variability of behavioural and rCBF responses in the scanner environment., NEUROIMAGE, Vol: 13, Pages: S1039-S1039, ISSN: 1053-8119
Lingford-Hughes AR, Acton PD, Gacinovic S, et al., 2000, Levels of ??-Aminobutyric Acid-Benzodiazepine Receptors in Abstinent, Alcohol-Dependent Women: Preliminary Findings From an 123I-Iomazenil Single Photon Emission Tomography Study, Alcoholism: Clinical and Experimental Research, Vol: 24, Pages: 1449-1455, ISSN: 0145-6008
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