Publications
324 results found
Nutt D, Lingford-Hughes A, 2004, Infecting the brain to stop addiction?, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 101, Pages: 11193-11194, ISSN: 0027-8424
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- Citations: 2
Lingford-Hughes A, 2004, Imaging GABA<sub>A</sub> receptor subtypes with PET., 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 75A-75A, ISSN: 0145-6008
Daglish MRC, Lingford-Hughes AR, Nutt DJ, 2004, Brain imaging alcohol cue-reactivity., 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 65A-65A, ISSN: 0145-6008
Nutt D, Lingford-Hughes A, 2004, Key concepts in psychopharmacology, Psychiatry, Vol: 3, Pages: 1-4, ISSN: 1476-1793
Pharmacology is a core discipline for psychiatry. The drug treatments used in psychiatry can be understood in terms of pharmacological actions such as agonism, antagonism and partial agonism. Both these treatments and other physical treatments (e.g. ECT) act on neurotransmitters and/or their receptors. An understanding of the different sort of receptors (e.g. pre- and postsynaptic receptors) is important in understanding how treatments work and also in designing newer ones with greater efficacy and fewer side-effects. Changes in neurotransmitters and/or their receptors are responsible for the therapeutic effects of many drugs and also problems with chronic administration such as tolerance, sensitization and withdrawal. In recent years, molecular biology has led to a genetic dissection of neurotransmitter receptors, revealing families of receptors which are linked to different second messengers and which give a diversity in action that can explain the wide roles of key neurotransmitters such as serotonin, dopamine and noradrenaline. This molecular dissection is also leading to more targeted treatments that modify just one receptor subtype. Such drugs are likely to be the future of psychopharmacology, and understanding the basis of this is important for practising psychiatrists. © 2004 Elsevier Ltd. All rights reserved.
Fogarty A, Lingford-Hughes A, 2004, Addiction and substance misuse, Medicine, Vol: 32, Pages: 29-33, ISSN: 1357-3039
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- Citations: 1
Nutt DJ, Lingford-Hughes AR, 2004, Infecting the brain to stop addiction?, Proceedings of the National Academy of Sciences of USA, Vol: 101, Pages: 11193-11194
Daglish MRC, Weinstein A, Malizia AL, et al., 2003, Functional connectivity analysis of the neural circuits of opiate craving: "more" rather than "different"?, Neuroimage, Vol: 20, Pages: 1964-1970
We investigated the functional connectivity of brain regions activated during opiate craving. Previously we used recorded autobiographical scripts to induce opiate craving in 12 abstinent opiate-dependent subjects while they were undergoing positron emission tomography (PET) scanning using the regional cerebral blood flow (rCBF) tracer H2 15O. SPM99 was used to examine the connectivity patterns associated with the primary brain regions activated in response to drug-craving memories (anterior cingulate, AC) and correlated with opiate craving (orbitofrontal cortex, OFC). Two separate connectivity patterns were identified associated with the OFC and AC regions. The AC region was associated with activity in the left temporal region. The left OFC region activity correlated with activity in the right OFC, and left parietal and posterior insular regions. There was also a positive association with the hippocampus and brainstem. Both the AC and OFC regions showed a negative association with posterior visual areas. We suggest that the patterns of functional connectivity reflect the ability of drug-related stimuli to activate attentional and memory circuits to a greater degree than non-drug-related stimuli. This argues that neural circuits of dependence and craving are not specific "craving" or "addiction" brain regions but are "normal" circuits activated to a greater degree
Lingford-Hughes A, 2003, Neuroimaging studies of GABA<sub>A</sub> receptors and alcoholism, 10th Biennial Meeting of the European-Behavioural-Pharmacology-Society, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S6-S6, ISSN: 0955-8810
Melichar JK, Witchel HJ, Taylor LG, et al., 2003, Heart rate variability (HRV) and noradrenergic dysfunction in generalised anxiety disorder (GAD): Assessment using a clonidine challenge, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A29-A29, ISSN: 0269-8811
Weinstein A, Feldtkeller B, Feeney A, et al., 2003, A pilot study on the effects of treatment with acamprosate on craving for alcohol in alcohol-dependent patients, ADDICTION BIOLOGY, Vol: 8, Pages: 229-232, ISSN: 1355-6215
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- Citations: 16
Williams TM, Daglish MRC, Lingford-Hughes A, et al., 2003, Regional cerebral increases in opioid receptor density in early abstinence from methadone: a PET study in man, 4th ECNP Workshop 2003, Publisher: ELSEVIER SCIENCE BV, Pages: S31-S31, ISSN: 0924-977X
Lingford-Hughes A, Nutt D, 2003, Neurobiology of addiction and implications for treatment, BRITISH JOURNAL OF PSYCHIATRY, Vol: 182, Pages: 97-100, ISSN: 0007-1250
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- Citations: 61
Nutt D, Lingford-Hughes A, Daglish M, 2003, Future directions in substance dependence research, JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT, Pages: 95-103, ISSN: 0303-6995
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- Citations: 5
Lingford-Hughes AR, Nutt DJ, 2003, The neurobiology of addiction and implications for treatment., British Journal of Psychiatry, Vol: 182, Pages: 97-100
Lingford-Hughes A, Davies SJC, McIver S, et al., 2003, Addiction, BRITISH MEDICAL BULLETIN, Vol: 65, Pages: 209-222, ISSN: 0007-1420
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- Citations: 29
Lingford-Hughes A, 2002, Imaging GABAA receptor subtypes with PET, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 12, Pages: S136-S137, ISSN: 0924-977X
Lingford-Hughes A, 2002, There is more to dopamine than just pleasure.: Commentary on Volkow e<i>t al</i>. 'Role of dopamine in drug reinforcement and addiction in humans:: results from imaging studies', BEHAVIOURAL PHARMACOLOGY, Vol: 13, Pages: 367-370, ISSN: 0955-8810
Daglish MRC, Lingford-Hughes A, Williams TM, et al., 2002, A human pet study of dopamine response to hydromorphone, BEHAVIOURAL PHARMACOLOGY, Vol: 13, Pages: 479-480, ISSN: 0955-8810
Daglish MRC, Weinstein A, Malizia AL, et al., 2002, Functional connectivity analysis of rCBF in opiate craving, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A55-A55, ISSN: 0269-8811
Melichar JK, Taylor LG, Daglish MRC, et al., 2002, Noradrenergic dysfunction in generalised anxiety disorder (GAD): A SPET study using a clonidine challenge., Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A52-A52, ISSN: 0269-8811
Williams TM, Daglish MRC, Lingford-Hughes A, et al., 2002, Altered brain opioid receptor density after withdrawal from methadone treatment, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A54-A54, ISSN: 0269-8811
Daglish M, Lingford-Hughes A, Williams T, et al., 2002, Does opioid induced dopamine release in humans require a subjective "high"? A pet study with 11C-raclopride, NEUROIMAGE, Vol: 16, Pages: S95-S95, ISSN: 1053-8119
Lingford-Hughes A, Hume S, Feeney A, et al., 2002, [11C]Ro15 4513 PET predominantly labels the α5-containing GABA-benzodiazepine receptor <i>in vivo</i>, NEUROIMAGE, Vol: 16, Pages: S27-S27, ISSN: 1053-8119
Lingford-Hughes A, Hume SP, Feeney A, et al., 2002, Imaging the GABA-benzodiazepine receptor subtype containing the α5-subunit <i>in vivo</i> with [<SUP>11</SUP>C]Ro15 4513 positron emission tomography, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 22, Pages: 878-889, ISSN: 0271-678X
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- Citations: 94
Lingford-Hughes A, Daglish MRC, Wilson S, et al., 2002, Blood flow changes in abstinent addicts during cue exposure and craving for their drug of choice, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 12, Pages: S21-S22, ISSN: 0924-977X
Daglish MRC, Lingford-Hughes A, Williams T, et al., 2002, A PET study testing the dopamine hypothesis in opiate dependence in humans, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 12, Pages: S22-S23, ISSN: 0924-977X
Lingford-Hughes A, Hume SP, Feeney A, et al., 2002, Imaging in vivo the GABA-benzodiazepine receptor containing the α5 subunit in man and rat, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 12, Pages: S20-S20, ISSN: 0924-977X
Wilson S, Lingford-Hughes A, Cunningham VJ, et al., 2002, Assessing the function of the GABA-benzodiazepine receptor in alcohol dependence using PET and EEG, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 12, Pages: S21-S21, ISSN: 0924-977X
Daglish MRC, Lingford-Hughes A, Williams TM, et al., 2002, A PET study of brain opioid receptor changes after withdrawal from chronic methadone treatment, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 12, Pages: S22-S22, ISSN: 0924-977X
Melichar JK, Taylor LG, Daglish MRC, et al., 2002, A single photon emission tomography (SPET) study of noradrenergic function in generalised anxiety disorder (GAD), EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 12, Pages: S20-S21, ISSN: 0924-977X
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