Publications
324 results found
Lingford-Hughes A, Potokar J, Nutt D, 2002, Treating anxiety complicated by substance misuse, Advances in Psychiatric Treatment, Vol: 8, Pages: 107-116, ISSN: 1355-5146
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- Citations: 13
Lingford-Hughes AR, Hume SP, Feeney A, et al., 2002, Imaging the GABA-benzodiazepine receptor subtype containing the a5-subunit in vivo with PET., Journal of Pharmacology and Experimental Therapeutics, Vol: 22, Pages: 878-889
Daglish MR, Weinstein A, Malizia AL, et al., 2001, Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects, Am.J.Psychiatry, Vol: 158, Pages: 1680-1686
OBJECTIVE: The brain circuitry of opiate craving was investigated with positron emission tomography (PET) imaging of regional cerebral blood flow (rCBF). METHOD: Twelve abstinent opiate-dependent subjects listened to audiotaped autobiographical scripts of an episode of craving and a neutral episode while undergoing a PET scan with the tracer [(15)O]H(2)O. Statistical parametric mapping was used to analyze the PET images of rCBF changes. RESULTS: Comparison of the drug-related and neutral stimulus conditions revealed activation of rCBF in the left medial prefrontal and left anterior cingulate cortices and deactivation in the occipital cortex in response to the drug-related stimulus. A further statistical parametric mapping analysis with a subjective rating of craving as a covariate showed a positive association of between craving and rCBF in the left orbitofrontal cortex. CONCLUSIONS: The patterns of cerebral activation reflect the different brain regions mediating the salience of opiate-related stimuli and the subjective experience of craving for opiates
Daglish M, Lingford-Hughes A, Stevenson B, et al., 2001, Mapping neural activation to alcohol cues in abstinent alcoholics - variability of behavioural and rCBF responses in the scanner environment., NEUROIMAGE, Vol: 13, Pages: S1039-S1039, ISSN: 1053-8119
Lingford-Hughes AR, Acton PD, Gacinovic S, et al., 2000, Levels of ??-Aminobutyric Acid-Benzodiazepine Receptors in Abstinent, Alcohol-Dependent Women: Preliminary Findings From an 123I-Iomazenil Single Photon Emission Tomography Study, Alcoholism: Clinical and Experimental Research, Vol: 24, Pages: 1449-1455, ISSN: 0145-6008
Lingford-Hughes AR, Cunningham VJ, Feeney AJ, et al., 2000, The function of the GABA-benzodiazepine receptor in alcohol dependence., JOURNAL OF NUCLEAR MEDICINE, Vol: 41, Pages: 136P-136P, ISSN: 0161-5505
Lingford-Hughes A, Nutt D, 2000, Alcohol and drug abuse, CURRENT OPINION IN PSYCHIATRY, Vol: 13, Pages: 291-298, ISSN: 0951-7367
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- Citations: 1
Daglish MR, Melichar JK, Lingford-Hughes AR, et al., 2000, <SUP>11</SUP>C-diprenorphine PET imaging of opioid binding during chronic methadone treatment and early abstinence., JOURNAL OF NUCLEAR MEDICINE, Vol: 41, Pages: 106P-106P, ISSN: 0161-5505
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- Citations: 2
Lingford-Hughes AR, Acton PD, Gacinovic S, et al., 2000, Levels of GABA-benzodiazepine receptors in female abstinent alcohol dependent subjects : preliminary findings from an [123I]-iomazenil single photon emission tomography study., Alcoholism-Clinical and Experimental Research, Vol: 24, Pages: 1449-1455
Suckling J, Brammer MJ, Lingford-Hughes A, et al., 1999, Removal of extracerebral tissues in dual-echo magnetic resonance images via linear scale-space features, MAGNETIC RESONANCE IMAGING, Vol: 17, Pages: 247-256, ISSN: 0730-725X
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- Citations: 51
Lingford-Hughes A, Malizia A, 1999, Measurement of brain GABA-benzodiazepine receptor levels in vivo using emission tomography., Methods Mol Biol, Vol: 106, Pages: 119-136, ISSN: 1064-3745
Weinstein A, Lingford-Hughes A, Martinez-Raga J, et al., 1998, What makes alcohol-dependent individuals early in abstinence crave for alcohol: Exposure to the drink, images of drinking, or remembrance of drinks past?, ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, Vol: 22, Pages: 1376-1381, ISSN: 0145-6008
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- Citations: 23
Weinstein A, Lingford-Hughes A, Martinez-Raga J, et al., 1998, What Makes Alcohol-Dependent Individuals Early in Abstinence Crave for Alcohol, Alcoholism: Clinical & Experimental Research, Vol: 22, Pages: 1376-1376, ISSN: 0145-6008
Lingford-Hughes AR, Acton PD, Gacinovic S, et al., 1998, Reduced levels of GABA-benzodiazepine receptor in alcohol dependency in the absence of grey matter atrophy, BRITISH JOURNAL OF PSYCHIATRY, Vol: 173, Pages: 116-122, ISSN: 0007-1250
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- Citations: 91
Lingford-Hughes A, Marshall J, 1998, New drug treatments for alcohol problems. Response to Moncrieff & Drummond., Addiction, Vol: 93, Pages: 925-927, ISSN: 0965-2140
Lingford-Hughes A, Marshall J, 1998, Response to Moncrieff & Drummond, ADDICTION, Vol: 93, Pages: 925-926, ISSN: 0965-2140
, 1998, Letters to the Editor, Addiction, Vol: 93, Pages: 925-928, ISSN: 0965-2140
Lingford-Hughes AR, Acton PD, Gacinovic S, et al., 1998, Gender differences in the pattern of reduced levels of the GABA benzodiazepine receptor in alcohol dependency - An L23 I-iomazenil SPECT and MRI study., JOURNAL OF NUCLEAR MEDICINE, Vol: 39, Pages: 204P-204P, ISSN: 0161-5505
Suckling J, Bullmore E, Lingford-Hughes A, 1997, A computational method for locating the brain in structural MR imaging, NeuroImage, Vol: 5, ISSN: 1053-8119
Busatto GF, Pilowsky LS, Costa DC, et al., 1997, Initial evaluation of I-123-5-I-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects (vol 24, pg 119, 1997), EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Vol: 24, Pages: 707-707, ISSN: 0340-6997
Busatto GF, Pilowsky LS, Costa DC, et al., 1997, Initial evaluation of I-123-5-I-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects, EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Vol: 24, Pages: 119-124, ISSN: 0340-6997
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- Citations: 51
LingfordHughes A, 1996, Characterisation of the effects of alcohol use and abuse on the brain, JOURNAL OF THE ROYAL SOCIETY OF HEALTH, Vol: 116, Pages: 122-123, ISSN: 0264-0325
BUSATTO GF, PILOWSKY LS, COSTA DC, et al., 1995, IN-VIVO IMAGING OF GABA(A) RECEPTORS USING SEQUENTIAL WHOLE-VOLUME I-123 IOMAZENIL SINGLE-PHOTON EMISSION TOMOGRAPHY, EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Vol: 22, Pages: 12-16, ISSN: 0340-6997
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- Citations: 8
MORROW AL, MONTPIED P, LINGFORDHUGHES A, et al., 1990, CHRONIC ETHANOL AND PENTOBARBITAL ADMINISTRATION IN THE RAT - EFFECTS ON GABA-A RECEPTOR FUNCTION AND EXPRESSION IN BRAIN, ALCOHOL, Vol: 7, Pages: 237-244, ISSN: 0741-8329
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- Citations: 126
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