Publications
324 results found
Kalk NJ, Guo Q, Owen DR, et al., 2013, Using Positron Emission Tomography to investigate microglial activation in alcohol dependence: preliminary findings, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: S122-S122, ISSN: 0924-977X
Lingford-Hughes A, 2013, Neurobiology of alcohol dependence, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: S634-S634, ISSN: 0924-977X
Emsley E, Lees R, Lingford-Hughes A, et al., 2013, Annual General Meeting of the British NeuroPsychiatry Association, London, England, February 7-8, 2013 Abstracts, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 84, ISSN: 0022-3050
Kalk N, Cherian R, Naveed M, et al., 2013, THE PERIPHERAL CYTOKINE PROFILE IN ALCOHOL DETOXIFICATION: RELATIONSHIP TO COGNITIVE FUNCTION
Mendez MA, Horder J, Myers J, et al., 2013, The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: A pilot [<SUP>11</SUP>C]Ro15-4513 positron emission tomography study, NEUROPHARMACOLOGY, Vol: 68, Pages: 195-201, ISSN: 0028-3908
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- Citations: 75
Muthukumaraswamy SD, Myers JFM, Wilson SJ, et al., 2013, Elevating Endogenous GABA Levels with GAT-1 Blockade Modulates Evoked but Not Induced Responses in Human Visual Cortex, NEUROPSYCHOPHARMACOLOGY, Vol: 38, Pages: 1105-1112, ISSN: 0893-133X
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- Citations: 27
Stokes PRA, Benecke A, Myers J, et al., 2013, History of cigarette smoking is associated with higher limbic GABAA receptor availability, Neuroimage, Vol: 69, Pages: 70-77
Cigarette smoking presents a significant worldwide healthcare challenge. Preclinical, genetic association and clinical trials studies provide considerable evidence for the involvement of the human γ-aminobutyric acid (GABA) system in the neurobiology of nicotine addiction. However there are few human GABA neurochemical imaging studies of nicotine addiction. We investigated limbic GABAA receptor availability in volunteers with a history of cigarette smoking using [11C]Ro15 4513 positron emission tomography (PET). Eight [11C]Ro15 4513 PET scans from volunteers with a history of cigarette smoking were compared to twelve scans from volunteers who were non-smokers. Total, α1 and α5 GABAA receptor subtype [11C]Ro15 4513 VT values were quantified using spectral analysis of limbic regions implicated in nicotine addiction. Spectral analysis allows quantification of the overall [11C]Ro15 4513 spectral frequency as well as α1 and α5 GABAA receptor subtype specific spectral frequency components. Volunteers with a history of cigarette smoking showed significantly higher total [11C]Ro15 4513 VT values in the presubgenual cingulate and parahippocampal gyrus, and at a trend level in the insula, nucleus accumbens and subgenual cingulate. In six abstinent previous smokers (‘ex-smokers’), total [11C]Ro15 4513 binding was significantly higher in all limbic regions studied, with higher α5 availability in the amygdala, anterior cingulate, nucleus accumbens and presubgenual cingulate. These results suggest that limbic GABAA receptor availability is higher in volunteers with a history of cigarette smoking which may reflect either higher expression of GABAA receptors or lower endogenous GABA levels. The findings in ex-smokers suggest that higher GABAA receptor availability continues with abstinence indicating that this may be a trait marker for nicotine addiction or that alterations in GABA function associated with cigarette smoking persist.
Kalk NJ, Guo Q, Cherian R, et al., 2013, Using positron emission tomography to investigate microglial activation in alcohol dependence: preliminary findings, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: S87-S88, ISSN: 0924-977X
Colasanti A, Lingford-Hughes A, Nutt D, 2013, Opioids Neuroimaging, Biological Research on Addiction: Comprehensive Addictive Behaviors and Disorders, Pages: 675-687, ISBN: 9780123983350
Muthukumaraswamy SD, Myers JFM, Wilson SJ, et al., 2013, The effects of elevated endogenous GABA levels on movement-related network oscillations, NEUROIMAGE, Vol: 66, Pages: 36-41, ISSN: 1053-8119
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- Citations: 124
Stokes PR, Shotbolt P, Mehta MA, et al., 2013, Nature or Nurture? Determining the Heritability of Human Striatal Dopamine Function: an [18F]-DOPA PET Study, Neuropsychopharmacology, Vol: 38, Pages: 485-491
Striatal dopamine function is important for normal personality, cognitive processes and behavior, and abnormalities are linked to a number of neuropsychiatric disorders. However, no studies have examined the relative influence of genetic inheritance and environmental factors in determining striatal dopamine function. Using [18F]-DOPA positron emission tomography (PET), we sought to determine the heritability of presynaptic striatal dopamine function by comparing variability in uptake values in same sex monozygotic (MZ) twins to dizygotic (DZ) twins. Nine MZ and 10 DZ twin pairs underwent high-resolution [18F]-DOPA PET to assess presynaptic striatal dopamine function. Uptake values for the overall striatum and functional striatal subdivisions were determined by a Patlak analysis using a cerebellar reference region. Heritability, shared environmental effects and non-shared individual-specific effects were estimated using a region of interest (ROI) analysis and a confirmatory parametric analysis. Overall striatal heritability estimates from the ROI and parametric analyses were 0.44 and 0.33, respectively. We found a distinction between striatal heritability in the functional subdivisions, with the greatest heritability estimates occurring in the sensorimotor striatum and the greatest effect of individual-specific environmental factors in the limbic striatum. Our results indicate that variation in overall presynaptic striatal dopamine function is determined by a combination of genetic factors and individual-specific environmental factors, with familial environmental effects having no effect. These findings underline the importance of individual-specific environmental factors for striatal dopaminergic function, particularly in the limbic striatum, with implications for understanding neuropsychiatric disorders such as schizophrenia and addictions.
Colasanti A, Lingford-Hughes A, Nutt D, 2013, Opioids Neuroimaging, BIOLOGICAL RESEARCH ON ADDICTION: COMPREHENSIVE ADDICTIVE BEHAVIORS AND DISORDERS, VOL 2, Editors: Miller, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 675-687
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- Citations: 2
Lees R, Lingford-Hughes A, 2012, Neurobiology and principles of addiction and tolerance, Medicine (United Kingdom), Vol: 40, Pages: 633-636, ISSN: 1357-3039
Substances of abuse dysregulate the major pathways underlying aspects of motivation, reward, decision-making and memory. As drug use evolves from an impulsive to compulsive action, the brain undergoes neuro-adaptation, during which there is a shift in the importance of different neurotransmitters. Dopamine plays an important role in addiction, providing initial pleasure to a drug, or a positive reinforcing drug effect that leads subsequently to motivation and drug seeking. As an individual becomes tolerant, there is a shift away from dopaminergic pathways towards the involvement of excitatory glutamatergic pathways. Although addiction can be observed for all drugs of abuse, the underlying neurotransmitters and adaptions can vary between drugs. This review focuses on the neurobiology of addiction and tolerance for alcohol, benzodiazepines, opioids, and stimulants. © 2012 Elsevier Ltd. All rights reserved.
Clark L, Stokes PR, Wu K, et al., 2012, Striatal dopamine D<sub>2</sub>/D<sub>3</sub> receptor binding in pathological gambling is correlated with mood-related impulsivity, NEUROIMAGE, Vol: 63, Pages: 40-46, ISSN: 1053-8119
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- Citations: 109
Lingford-Hughes A, Myers JF, Watson B, et al., 2012, Imaging GABA-benzodiazepine receptor subtypes in addiction, 25th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S133-S133, ISSN: 0924-977X
Lingford-Hughes A, Meyers J, Wilson S, et al., 2012, IMAGING THE GABA-BENZODIAZEPINE RECEPTOR IN ALCOHOLISM WITH PET, 16th World Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA), Publisher: WILEY-BLACKWELL, Pages: 40A-40A, ISSN: 0145-6008
Sanatinia R, Barrett B, Byford S, et al., 2012, Brief intervention for alcohol misuse in people attending sexual health clinics: study protocol for a randomized controlled trial, TRIALS, Vol: 13
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- Citations: 4
Myers JFM, Stokes PRA, Kalk NJ, et al., 2012, Sensitivity of the benzodiazepine inverse agonist PET ligand [C-11]Ro15-4513 to changes in endogenous GABA, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: NATURE PUBLISHING GROUP, Pages: S66-S67, ISSN: 0271-678X
Stokes P, Myers J, Benecke A, et al., 2012, History of cigarette smoking associated with increased limbic GABA<sub>A</sub> receptor availability, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: NATURE PUBLISHING GROUP, Pages: S46-S47, ISSN: 0271-678X
Erritzoe D, Tziortzi A, Bargiela D, et al., 2012, <i>In vivo</i> imaging of dopamine D3 receptors in alcoholism using [<SUP>11</SUP>C]PHNO-PET, and a selective D3 receptor antagonist, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: SAGE PUBLICATIONS INC, Pages: S77-S78, ISSN: 0271-678X
Myers JFM, Stokes PRA, Kalk NJ, et al., 2012, Sensitivity of the benzodiazepine inverse agonist PET ligand [<SUP>11</SUP>C]Ro15-4513 to changes in endogenous GABA, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: NATURE PUBLISHING GROUP, Pages: S66-S66, ISSN: 0271-678X
Stokes P, Shotbolt P, Mehta M, et al., 2012, Nature or nurture? Determining the heritability of human dopamine function: an [<SUP>18</SUP>F]-DOPA PET study, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: NATURE PUBLISHING GROUP, Pages: S50-S51, ISSN: 0271-678X
Kalk NJ, Owen D, Reynolds R, et al., 2012, Affinity of commonly-prescribed benzodiazepines for the 18 kDa translocator protein (TSPO): implications for imaging studies, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: NATURE PUBLISHING GROUP, Pages: S52-S53, ISSN: 0271-678X
Lingford-Hughes AR, Welch S, Peters L, et al., 2012, BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 26, Pages: 899-952, ISSN: 0269-8811
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- Citations: 170
Wood D, Bowden-Jones O, Lingford-Hughes A, et al., 2012, Management of acute gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) withdrawal: use of CIWA-Ar scoring is not sufficient in determining need for benzodiazepine treatment, Conference of the BPS Clinical Pharmacological Section, Publisher: WILEY-BLACKWELL, Pages: 1001-1002, ISSN: 0306-5251
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- Citations: 1
Nutt D, Owen D, Parker C, et al., 2012, Using PET to explore the role of the translocator pattern in human brain diseases, Publisher: OXFORD UNIV PRESS, Pages: 24-24, ISSN: 1461-1457
Kalk NJ, Newson MJR, Cherian R, et al., 2012, CORTISOL AWAKENING RESPONSE DURING DETOXIFICATION DIFFERS IN PATIENTS WITH PSYCHIATRIC COMORBIDITY, 35th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA), Publisher: WILEY-BLACKWELL, Pages: 147A-147A, ISSN: 0145-6008
Lingford-Hughes A, Kalk N, 2012, Clinical neuroanatomy, Core Psychiatry: Third Edition, Pages: 13-34, ISBN: 9780702033971
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- Citations: 5
Kalk NJ, Melichar J, Holmes RB, et al., 2012, Central noradrenergic responsiveness to a clonidine challenge in Generalized Anxiety Disorder: a Single Photon Emission Computed Tomography study, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 26, Pages: 452-460, ISSN: 0269-8811
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- Citations: 9
Mendez MA, Myers JFM, Coghlan S, et al., 2012, An investigation of the role of the brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder (ASD) using the PET ligand [<SUP>11</SUP>C]Ro15-4513, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 22, Pages: S63-S64, ISSN: 0924-977X
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