Publications
324 results found
Stokes PRA, Benecke A, Shotbolt JP, et al., 2012, Human impulsivity is not associated with variation in presynaptic striatal dopamine synthesis capacity, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 22, Pages: S66-S67, ISSN: 0924-977X
Lees R, Kingston R, Williams TM, et al., 2012, Comparison of Ethyl Glucuronide in Hair with Self-Reported Alcohol Consumption, ALCOHOL AND ALCOHOLISM, Vol: 47, Pages: 267-272, ISSN: 0735-0414
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- Citations: 34
Lingford-Hughes A, Reid AG, Myers J, et al., 2012, A [<SUP>11</SUP>C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 26, Pages: 273-281, ISSN: 0269-8811
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- Citations: 34
Nutt DJ, Lingford-Hughes A, Chick J, 2012, Through a glass darkly: can we improve clarity about mechanism and aims of medications in drug and alcohol treatments?, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 26, Pages: 199-204, ISSN: 0269-8811
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- Citations: 12
Stokes PRA, Egerton A, Watson B, et al., 2012, History of cannabis use is not associated with alterations in striatal dopamine D<sub>2</sub>/D<sub>3</sub> receptor availability, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 26, Pages: 144-149, ISSN: 0269-8811
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- Citations: 45
Nutt D, Lingford-Hughes A, Nestor L, 2012, Brain Imaging in Addiction, ADDICTION NEUROETHICS: THE ETHICS OF ADDICTION NEUROSCIENCE RESEARCH AND TREATMENT, Editors: Carter, Hall, Illes, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 3-25, ISBN: 978-0-12-385973-0
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- Citations: 3
Colasanti A, Searle GE, Long CJ, et al., 2012, Endogenous opioid release in the human brain reward system induced by acute amphetamine administration, Biol Psychiatry, Vol: 72, Pages: 371-377, ISSN: 1873-2402
BACKGROUND: We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). METHODS: Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a "high" dose, .5 mg/kg, or a sub-pharmacological "ultra-low" dose, 1.25 mg total dose or approximately .017 mg/kg). Reductions in [(11)C]carfentanil binding from baseline to post-amphetamine scans (DeltaBP(ND)) after the "high" and "ultra-low" amphetamine doses were assessed in 10 regions of interest. RESULTS: [(11)C]carfentanil binding was reduced after the "high" but not the "ultra-low" amphetamine dose in the frontal cortex, putamen, caudate, thalamus, anterior cingulate, and insula. CONCLUSIONS: Our findings indicate that oral amphetamine administration induces endogenous opioid release in different areas of human brain, including basal ganglia, frontal cortex areas, and thalamus. The combination of an amphetamine challenge and [(11)C]carfentanil PET is a practical and robust method to probe the opioid system in the living human brain.
Reid AG, Lingford-Hughes AR, Cancela LM, et al., 2012, Substance abuse disorders, NEUROBIOLOGY OF PSYCHIATRIC DISORDERS, Vol: 106, Pages: 419-431, ISSN: 0072-9752
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- Citations: 12
Thomson AD, Guerrini I, Bell D, et al., 2012, Alcohol-related brain damage: report from a Medical Council on Alcohol Symposium, June 2010., Alcohol Alcohol, Vol: 47, Pages: 84-91
Colasanti A, Rabiner EA, Lingford-Hughes A, et al., 2011, Opioids and anxiety, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 25, Pages: 1415-1433, ISSN: 0269-8811
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- Citations: 67
Kalk N, Rabiner EA, Lingford-Hughes AR, 2011, IMAGING NEUROINFLAMMATION IN ALCOHOLISM, Publisher: OXFORD UNIV PRESS, Pages: 13-13, ISSN: 0735-0414
Watson BJ, Taylor LG, Reid A, et al., 2011, Investigating the effect of expectation on striatal dopamine release in heroin addicts: an <SUP>11</SUP>C-raclopride PET study, 24th Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S320-S320, ISSN: 0924-977X
Stokes PR, Clark L, Wu K, et al., 2011, IMAGING THE DOPAMINE SYSTEM IN PATHOLOGICAL GAMBLING: AN [11C]-RACLOPRIDE PET STUDY, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A61-A61, ISSN: 0269-8811
Lingford-Hughes A, Myers J, Wilson S, et al., 2011, THE GABA-BENZODIAZEPINE RECEPTOR, ITS SUBTYPES AND ALCOHOL MISUSE: INSIGHTS FROM IMAGING AND PHARMACOLOGICAL CHALLENGE STUDIES, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A79-A79, ISSN: 0269-8811
Benecke A, Shotbolt JP, Egerton A, et al., 2011, DOES PRESYNAPTIC STRIATAL DOPAMINE SYNTHESIS CAPACITY PREDICT SOCIALLY DESIRABLE RESPONDING?, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A42-A42, ISSN: 0269-8811
Watson BJ, Wilson S, Griffin L, et al., 2011, A pilot study of the effectiveness of D-cycloserine during cue-exposure therapy in abstinent alcohol-dependent subjects, PSYCHOPHARMACOLOGY, Vol: 216, Pages: 121-129, ISSN: 0033-3158
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- Citations: 28
Watson BJ, Wilson S, Griffin L, et al., 2011, A pilot study of the effectiveness of D-cycloserine during cue-exposure therapy in abstinent alcohol-dependent subjects, Pages: 121-129
RATIONALE: Cue-exposure therapy (CET) has been advocated as a potentially effective treatment of addictive behaviours. Strategies that enhance learning may improve the outcome of CET. D-cycloserine (DCS), a partial N-methyl-D-aspartate receptor agonist, has been shown to facilitate extinction of learned fear in rats and augment exposure-based treatment in some anxiety disorders in man. OBJECTIVE: This double-blind placebo-controlled pilot study used a cue-exposure paradigm, salient for an individual's alcohol drinking, to see if DCS would reduce cue-reactivity compared with placebo. METHODS: Sixteen abstinent, alcohol-dependent individuals were randomised to receive either a single-dose (250 mg) DCS or placebo before CET sessions, separated by at least 1 week. Subjective responses were assessed using the Alcohol Urge Questionnaire (AUQ) and visual analogue scales. Cardiovascular responses were assessed using Finapres(c). RESULTS: The cue-exposure paradigm significantly increased craving assessed with the AUQ during the first session. In subsequent sessions, the degree of craving was reduced. However, no significant difference was seen between the DCS and placebo groups in any outcome measure. The variability of responses between individuals was great with more than half the groups reporting no or very small changes in AUQ scores. CONCLUSION: This is the first human study to our knowledge to assess the efficacy of DCS in facilitating CET in alcohol dependence. The high proportion of subjects with little or no response to cue-exposure would make any effect of DCS very difficult to detect. It is important that future studies carefully consider the criteria for inclusion
Erritzoe D, Tziortzi A, Bargiela D, et al., 2011, In Vivo Imaging of Dopamine D3 Receptors in Alcoholism Using Positron Emission Tomography, [11C]PHNO, and a Selective D3 Receptor Antagonist, 66th Annual Meeting of the Society-of-Biological-Psychiatry, Publisher: ELSEVIER SCIENCE INC, Pages: 271S-271S, ISSN: 0006-3223
Nutt D, Lingford-Hughes A, Nestor L, 2011, Brain Imaging in Addiction, Addiction Neuroethics: The Ethics of Addiction Neuroscience Research and Treatment, Pages: 3-25, ISBN: 9780123859730
This chapter focuses on neuroimaging techniques, explaining their relevance to understanding drug addiction. There are two main divisions in neuroimaging techniques: structural and functional. The former measures features of brain structure such as its size, shape, and density. Functional magnetic resonance imaging (fMRI) exploits the fact that the magnetic property of blood changes when oxygen is removed. This can be detected using an MRI paradigm known as the BOLD signal. Structural magnetic resonance imaging technique measures the volume and shape of the brain with reasonable precision. It can be used to investigate potential structural differences in the brains of certain populations. The endorphin system is the major target for the opioid drugs such as morphine and heroin. It has long been implicated in processes such as interpersonal bonding, love, and, when lacking, pain. Drug dependence is commonly associated with emotional, cognitive, and behavioral reactivity to drug-related stimuli or to images or events associated with drug use.
Hood SD, Melichar JK, Taylor LG, et al., 2011, Noradrenergic function in generalized anxiety disorder: impact of treatment with venlafaxine on the physiological and psychological responses to clonidine challenge, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 25, Pages: 78-86, ISSN: 0269-8811
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- Citations: 16
Kalk NJ, Nutt DJ, Lingford-Hughes AR, 2011, The role of central noradrenergic dysregulation in anxiety disorders: evidence from clinical studies, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 25, Pages: 3-16, ISSN: 0269-8811
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- Citations: 59
Kalk NJ, Melichar J, Holmes RB, et al., 2011, Central noradrenergic responsiveness to a clonidine challenge in Generalized Anxiety Disorder: a Single Photon Emission Computed Tomography Study., Journal of Psychopharmacology
Myers JFM, Rosso L, Watson BJ, et al., 2011, Characterization of the contribution of the GABA-benzodiazepine α1 receptor subtype to [11C]Ro15-4513 PET images., Journal of Cerebral Blood Flow and Metabolism
Stokes PRA, Egerton A, Watson B, et al., 2010, Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge, NEUROIMAGE, Vol: 52, Pages: 1521-1527, ISSN: 1053-8119
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- Citations: 57
Tyacke RJ, Lingford-Hughes A, Reed LJ, et al., 2010, GABAB Receptors in Addiction and Its Treatment, Vol: 58, Pages: 373-396
The GABAB receptor plays an important role in the control of neuro- transmitter release, and experiments using preclinical models have shown that modulation of this receptor can have profound effects on the reward process. This ability to affect the reward process has led to clinical investiga- tions into the possibility that this could be a viable target in the treatment of addiction. Presented here is an overview of a number of studies testing this hypothesis in different drug dependencies. The studies reviewed have used the GABAB receptor agonist baclofen, which is currently the only GABAB agonist for use in humans. In addition, studies using the non-specific GABAB receptor agonists vigabatrin and tiagabine have been included. In some of the studies these were found to have efficacy in the initiation and mainte- nance of abstinence, as an anti-craving treatment and alleviation of with- drawal syndromes, while in other studies showing limited effects. However, there is enough evidence to suggest that modulators of the GABAB receptor have potential as adjunct treatments to aid in the initiation of abstinence, maintenance of abstinence, and prevention of cue-related relapse in some addictions. This potential is at present poorly understood or studied and warrants further investigation.
Lingford-Hughes AR, Watson B, Daglish MR, et al., 2010, IMAGING THE ROLE OF DOPAMINE IN HUMAN OPIOID ADDICTS, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A8-A8, ISSN: 0269-8811
Stokes PRA, Shotbolt JP, Copeland C, et al., 2010, PREVIOUS COCAINE USE DECREASES PRESYNAPTIC LIMBIC DOPAMINERGIC FUNCTION: A [18F]-DOPA PET STUDY, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A57-A57, ISSN: 0269-8811
Myers JFM, Rosso L, Kalk NJ, et al., 2010, The effects of zolpidem on in vivo binding of [C11]-flumazenil and [C11]-Ro15-4513, 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S191-S192, ISSN: 1053-8119
Williams TM, Lees R, Lovell RM, et al., 2010, Respiratory changes following benzodiazepine administration in opioid-dependent human participants, 23rd Congress Meeting of European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S585-S586, ISSN: 0924-977X
Lees R, Williams T, Barford-Turner S, et al., 2010, RESPIRATORY CHANGES FOLLOWING ALCOHOL ADMINISTRATION IN OPIOID-DEPENDENT HUMAN PARTICIPANTS, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A30-A30, ISSN: 0269-8811
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