Imperial College London

Professor Anthony Gordon

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Anaesthesia and Critical Care
 
 
 
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Contact

 

anthony.gordon

 
 
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Location

 

ICUQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

139 results found

Russell JA, Walley KR, Singer J, Gordon AC, Hebert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers Det al., 2008, Vasopressin versus norepinephrine infusion in patients with septic shock, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 358, Pages: 877-887, ISSN: 0028-4793

Journal article

Gordon AC, LeBlanc ME, Walley KR, Russell JA, Siddiqui A, Wellman HF, Mooder K, Zhang Xet al., 2007, Protein C and PAI-1 genetic markers of mortality reduction in response to rhAPC in the VASST study, 37th Critical Care Congress of the Society-of-Critical-Care-Medicine, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A18-A18, ISSN: 0090-3493

Conference paper

Gordon AC, Walley KR, Russell JA, Wurfel MM, Martin TRet al., 2006, Hyperfunctioning polymorphism in the toll-like receptor 1 gene is associated with increased mortality in sepsis., CRITICAL CARE MEDICINE, Vol: 34, Pages: A18-A18, ISSN: 0090-3493

Journal article

Sutherland AM, Gordon AC, Russell JA, 2006, Are Vasopressin Levels Increased or Decreased in Septic Shock?, Critical Care Medicine, Vol: 34, Pages: 542-543

Journal article

Manocha S, Gordon AC, Salehifar E, Groshaus H, Walley KR, Russell JAet al., 2006, Inhaled beta-2 agonist salbutamol and acute lung injury: An association with improvement in acute lung injury, Critical Care, Vol: 10, ISSN: 1364-8535

Introductionβ2 agonists have several properties that could be beneficial in acute lung injury (ALI). We therefore chose to study the effect of inhaled β2 agonist use (salbutamol) on duration and severity of ALI.MethodsWe undertook a retrospective chart review of 86 consecutive mechanically ventilated patients with ALI, who had varying exposure to inhaled salbutamol. The cohort was divided into two groups according to the average daily dose of inhaled salbutamol they received ('high dose' ≥ 2.2 mg/day and 'low dose' <2.2 mg/day). Severity of ALI and non-pulmonary organ dysfunction was compared between the groups by calculating the days alive and free of ALI and other organ dysfunctions.ResultsThe high dose and low dose groups received a mean of 3.72 mg and 0.64 mg salbutamol per day, respectively. The high dose salbutamol group had significantly more days alive and free of ALI than the low dose group (12.2 ± 4.4 days versus 7.6 ± 1.9 days, p = 0.02). There were no associations between dose of β agonist and non-pulmonary organ dysfunctions. High dose salbutamol (p = 0.04), APACHE II score (p = 0.02), and cause of ALI (p = 0.02) were independent variables associated with number of days alive and free of ALI in a multivariate linear regression model.ConclusionOur retrospective study suggests that salbutamol, an inhaled β2 agonist, is associated with a shorter duration and lower severity of ALI. A dose greater than 2.2 mg/day of inhaled salbutamol could be a minimal effective dose to evaluate in a randomized controlled trial.

Journal article

Gordon AC, Russell JA, 2006, Reduction in airway epithelial chloride transport in septicaemia related pulmonary oedema reversible by beta agonist application - Response, CRITICAL CARE, Vol: 10, ISSN: 1466-609X

Journal article

Gordon AC, Waheed U, Hansen TK, Hitman GA, Garrard CS, Turner MW, Klein NJ, Brett SJ, Hinds CJet al., 2006, Mannose-binding lectin polymorphisms in severe sepsis: Relationship to levels, incidence, and outcome, SHOCK, Vol: 25, Pages: 88-93, ISSN: 1073-2322

Journal article

Gordon AC, Russell JA, 2005, Goal directed therapy: How long can we wait?, Critical Care, Vol: 9, Pages: 647-648, ISSN: 1364-8535

Intensive monitoring and aggressive management of perioperative haemodynamics (goal directed therapy) have repeatedly been reported to reduce the significant morbidity and mortality associated with high risk surgery. It may not matter what particular monitor is used to assess cardiac output but it is essential to ensure adequate oxygen delivery. If this management cannot begin preoperatively, it is still worth beginning goal directed therapy in the immediate postoperative period.

Journal article

Gordon AC, Oakervee HE, Kaya B, Thomas JM, Barnett MJ, Rohatiner AZS, Lister TA, Cavenagh JD, Hinds CJet al., 2005, Incidence and outcome of critical illness amongst hospitalised patients with haematological malignancy: a prospective observational study of ward and intensive care unit based care, ANAESTHESIA, Vol: 60, Pages: 340-347, ISSN: 0003-2409

Journal article

Gordon AC, Lagan AL, Aganna E, Cheung L, Peters CJ, McDermott MF, Millo JL, Welsh KI, Holloway P, Hitman GA, Piper RD, Garrard CS, Hinds CJet al., 2004, TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study, GENES AND IMMUNITY, Vol: 5, Pages: 631-640, ISSN: 1466-4879

Journal article

Peters CJ, Aganna E, Nanjee MN, Cheung L, Gordon AC, Piper RD, Hitman G, Miller NE, Hattori H, Hinds CJet al., 2003, Relationship of paraoxonase 1 R/Q polymorphism to outcome from severe sepsis and septic shock, Meeting of the Intensive-Care-Society, Publisher: OXFORD UNIV PRESS, Pages: 539P-539P, ISSN: 0007-0912

Conference paper

Oakervee HE, Gordon AC, Kaya B, Taussig DC, Lockley M, Barnett MJ, Rohatiner AZS, Lister TA, Hinds CJ, Cavenagh JDet al., 2002, Outcomes of critical illness in patients with haematological malignancy., 44th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 875A-876A, ISSN: 0006-4971

Conference paper

Peters CJ, Nanjee MN, Gordon AC, Miller NE, Hinds CJet al., 2002, Modification of High Density Lipoprotein in septic shock: relationship to outcome, 15th Annual Congress on European-Society-of-Internsive-Care-Medicine, Publisher: SPRINGER-VERLAG, Pages: S97-S97, ISSN: 0342-4642

Conference paper

Gordon AC, Oakervee HE, Kaya B, Barnett MJ, Rohatiner AZ, Lister TA, Watson JD, Cavenagh JD, Hinds CJet al., 2002, A prospective study of the incidence and outcome of critical illness in a haemato-oncology unit, 15th Annual Congress on European-Society-of-Internsive-Care-Medicine, Publisher: SPRINGER-VERLAG, Pages: S46-S46, ISSN: 0342-4642

Conference paper

Gordon AC, Cheung L, Aganna E, Peters CJ, McDermott MF, Hitman GA, Piper RD, Hinds CJet al., 2002, Lack of association between the-308 TNF promoter polymorphism & outcome from sepsis & septic shock, 15th Annual Congress on European-Society-of-Internsive-Care-Medicine, Publisher: SPRINGER-VERLAG, Pages: S99-S99, ISSN: 0342-4642

Conference paper

Gordon AC, Aganna E, Cheung L, Peters CJ, Piper RD, Mirakian RM, McDermott MF, Hitman GA, Hinds CJet al., 2002, Polymorphisms of the TNFRSF1B gene: Relationship to outcome from severe sepsis and septic shock, 15th Annual Congress on European-Society-of-Internsive-Care-Medicine, Publisher: SPRINGER-VERLAG, Pages: S99-S99, ISSN: 0342-4642

Conference paper

Peters CJ, Nanjee MN, Gordon AC, Miller NE, Hinds CJet al., 2002, Proinflammatory modifications of lipoprotein structure and function in patients with septic shock: relationship to outcome, Publisher: OXFORD UNIV PRESS, Pages: 361P-361P, ISSN: 0007-0912

Conference paper

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