Imperial College London

Professor Anthony Gordon

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Anaesthesia and Critical Care







ICUQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus






BibTex format

author = {Annane, D and Ouanes-Besbes, L and De, Backer D and Du, B and Gordon, AC and Hernandez, G and Olsen, K and Osborn, T and Peake, S and Russell, JA and Zanotti, Cavazzoni S},
doi = {10.1007/s00134-018-5242-5},
journal = {Intensive Care Medicine},
pages = {833--846},
title = {A global perspective on vasoactive agents in shock},
url = {},
volume = {44},
year = {2018}

RIS format (EndNote, RefMan)

AB - Purpose:We set out to summarize the current knowledge on vasoactive drugs and their use in the management of shock to inform physicians’ practices.Methods:This is a narrative review by a multidisciplinary, multinational—from six continents—panel of experts including physicians, a pharmacist, trialists, and scientists.Results and conclusions:Vasoactive drugs are an essential part of shock management. Catecholamines are the most commonly used vasoactive agents in the intensive care unit, and among them norepinephrine is the first-line therapy in most clinical conditions. Inotropes are indicated when myocardial function is depressed and dobutamine remains the first-line therapy. Vasoactive drugs have a narrow therapeutic spectrum and expose the patients to potentially lethal complications. Thus, these agents require precise therapeutic targets, close monitoring with titration to the minimal efficacious dose and should be weaned as promptly as possible. Moreover, the use of vasoactive drugs in shock requires an individualized approach. Vasopressin and possibly angiotensin II may be useful owing to their norepinephrine-sparing effects.
AU - Annane,D
AU - Ouanes-Besbes,L
AU - De,Backer D
AU - Du,B
AU - Gordon,AC
AU - Hernandez,G
AU - Olsen,K
AU - Osborn,T
AU - Peake,S
AU - Russell,JA
AU - Zanotti,Cavazzoni S
DO - 10.1007/s00134-018-5242-5
EP - 846
PY - 2018///
SN - 0342-4642
SP - 833
TI - A global perspective on vasoactive agents in shock
T2 - Intensive Care Medicine
UR -
UR -
VL - 44
ER -