Imperial College London

Professor Anthony Gordon

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Anaesthesia and Critical Care







ICUQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus






BibTex format

author = {Mich, V and Pho, Y and Bory, S and Vann, M and Teav, B and Som, L and Jarrvisalo, MJ and Pulkkinen, A and Kuitunen, A and Ala-kokko, T and Melto, S and Daix, T and Philippart, F and Antoine, M and Tiercelet, K and Bruel, C and Nicholas, S and Siami, S and Fabienne, T and Bruyere, R and Forceville, X and Erickson, S and Campbell, L and Sonawane, R and Santamaria, J and Kol, M and Awasthi, S and Powis, J and Hall, R and McCarthy, AE and Jouvet, P and Opaysky, MA and Gilfoyle, E and Farshait, N and Martin, D-A and Griesdale, D and Katz, K and Ruberto, AJ and Carrier, FM and Lamontagne, F and Muscedere, J and Rishu, A and Sin, WC and Ngai, WCW and Young, P and Forrest, A and Kazemi, A and Henderson, S and Browne, T and Ganeshalingham, A and McConnochie, R and Cho, JH and Park, TS and Sim, YS and Chang, Y and Lee, HB and Park, SY and Chan, WM and Lee, W-Y and Wallace, DJ and Angus, DC and Charles, AG and van, Doom HR and Nguyen, VK and Nguyen, VT and Prin, M and Twagirumugabe, T and Umuhire},
doi = {10.1136/bmjgh-2018-001061},
journal = {BMJ Global Health},
title = {Using research to prepare for outbreaks of severe acute respiratory infection},
url = {},
volume = {4},
year = {2019}

RIS format (EndNote, RefMan)

AB - Severe acute respiratory infections (SARI) remain one of the leading causes of mortality around the world in all age groups. There is large global variation in epidemiology, clinical management and outcomes, including mortality. We performed a short period observational data collection in critical care units distributed globally during regional peak SARI seasons from 1 January 2016 until 31 August 2017, using standardised data collection tools. Data were collected for 1 week on all admitted patients who met the inclusion criteria for SARI, with follow-up to hospital discharge. Proportions of patients across regions were compared for microbiology, management strategies and outcomes. Regions were divided geographically and economically according to World Bank definitions. Data were collected for 682 patients from 95 hospitals and 23 countries. The overall mortality was 9.5%. Of the patients, 21.7% were children, with case fatality proportions of 1% for those less than 5 years. The highest mortality was in those above 60 years, at 18.6%. Case fatality varied by region: East Asia and Pacific 10.2% (21 of 206), Sub-Saharan Africa 4.3% (8 of 188), South Asia 0% (0 of 35), North America 13.6% (25 of 184), and Europe and Central Asia 14.3% (9 of 63). Mortality in low-income and low-middle-income countries combined was 4% as compared with 14% in high-income countries. Organ dysfunction scores calculated on presentation in 560 patients where full data were available revealed Sequential Organ Failure Assessment (SOFA) scores on presentation were significantly associated with mortality and hospital length of stay. Patients in East Asia and Pacific (48%) and North America (24%) had the highest SOFA scores of >12. Multivariable analysis demonstrated that initial SOFA score and age were independent predictors of hospital survival. There was variability across regions and income groupings for the critical care management and outcomes of SARI. Intensive care unit-sp
AU - Mich,V
AU - Pho,Y
AU - Bory,S
AU - Vann,M
AU - Teav,B
AU - Som,L
AU - Jarrvisalo,MJ
AU - Pulkkinen,A
AU - Kuitunen,A
AU - Ala-kokko,T
AU - Melto,S
AU - Daix,T
AU - Philippart,F
AU - Antoine,M
AU - Tiercelet,K
AU - Bruel,C
AU - Nicholas,S
AU - Siami,S
AU - Fabienne,T
AU - Bruyere,R
AU - Forceville,X
AU - Erickson,S
AU - Campbell,L
AU - Sonawane,R
AU - Santamaria,J
AU - Kol,M
AU - Awasthi,S
AU - Powis,J
AU - Hall,R
AU - McCarthy,AE
AU - Jouvet,P
AU - Opaysky,MA
AU - Gilfoyle,E
AU - Farshait,N
AU - Martin,D-A
AU - Griesdale,D
AU - Katz,K
AU - Ruberto,AJ
AU - Carrier,FM
AU - Lamontagne,F
AU - Muscedere,J
AU - Rishu,A
AU - Sin,WC
AU - Ngai,WCW
AU - Young,P
AU - Forrest,A
AU - Kazemi,A
AU - Henderson,S
AU - Browne,T
AU - Ganeshalingham,A
AU - McConnochie,R
AU - Cho,JH
AU - Park,TS
AU - Sim,YS
AU - Chang,Y
AU - Lee,HB
AU - Park,SY
AU - Chan,WM
AU - Lee,W-Y
AU - Wallace,DJ
AU - Angus,DC
AU - Charles,AG
AU - van,Doom HR
AU - Nguyen,VK
AU - Nguyen,VT
AU - Prin,M
AU - Twagirumugabe,T
AU - Umuhire,OF
AU - Sylvain,H
AU - Al,Qasim E
AU - Heraud,J-M
AU - Raberahona,M
AU - Rabarison,JH
AU - Patrigeon,SP
AU - Ramirez-Venegas,A
AU - Melendez,JA
AU - Guerrero,ML
AU - Mambule,I
AU - Ochieng,OG
AU - Nadjm,B
AU - Choi,W-I
AU - Florence,K-P
AU - Arabi,YM
AU - West,TE
AU - Riviello,ED
AU - Parke,R
AU - Djillali,AE
AU - Fowler,R
AU - Murthy,S
AU - Nichol,A
AU - Cheng,AC
AU - Semple,C
AU - George,M
AU - Valkonen,M
AU - McArthur,C
AU - Carson,G
AU - O'Neill,G
AU - Cobb,JP
AU - Dunning,J
AU - Chiche,J-D
AU - Huh,J-W
AU - Marshall,J
AU - Rello,J
AU - Guillebaud,J
AU - Razanazatovo,N
AU - Otieno,JW
AU - Green,K
AU - Rowan,K
AU - Baillie,JK
AU - Merson,L
AU - Hsu,LY
AU - Christian,MD
AU - Egi,M
AU - Shindo,N
AU - Horby,P
AU - Pardinaz-Solis,R
AU - Ubiergo,SU
AU - Webb,SAR
AU - Uyeki,TM
AU - Gordon,AC
AU - Paterson,DL
AU - Everett,D
AU - Giamarellos-Bourboulis,EJ
AU - Longuere,K-S
AU - Maslove,D
AU - Ohuma,E
AU - Growl,G
AU - PedutemHumber,T
AU - EllazarHumber,E
AU - Bahinskaya,I
AU - Osbourne-Townsend,J
AU - Bentley,A
AU - Goodson,J
AU - Welters,I
AU - Malik,N
AU - Browne,TS
AU - Mahesh,V
DO - 10.1136/bmjgh-2018-001061
PY - 2019///
SN - 2059-7908
TI - Using research to prepare for outbreaks of severe acute respiratory infection
T2 - BMJ Global Health
UR -
UR -
UR -
UR -
VL - 4
ER -