Imperial College London

Professor Anthony Gordon

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Anaesthesia and Critical Care
 
 
 
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Contact

 

anthony.gordon

 
 
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Location

 

ICUQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Richards-Belle:2019:10.1177/1751143719870088,
author = {Richards-Belle, A and Mouncey, PR and Grieve, RD and Harrison, DA and Sadique, MZ and Henry, D and Whitman, C and Camsooksai, J and Gordon, AC and Young, JD and Rowan, KM and Lamontagne, F},
doi = {10.1177/1751143719870088},
journal = {Journal of the Intensive Care Society},
pages = {1--10},
title = {Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial},
url = {http://dx.doi.org/10.1177/1751143719870088},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Vasodilatory shock is common in critically ill patients and vasopressors are a mainstay of therapy. A meta-analysis suggested that use of a higher, as opposed to a lower, mean arterial pressure target to guide titration of vasopressor therapy, could be associated with a higher risk of death in older critically ill patients. The 65 trial is a pragmatic, multi-centre, parallel-group, open-label, randomised clinical trial of permissive hypotension (a mean arterial pressure target of 60–65 mmHg during vasopressor therapy) versus usual care in critically ill patients aged 65 years or over with vasodilatory hypotension. The trial is conducted in 2600 patients from 65 United Kingdom adult, general critical care units. The primary outcome is all-cause mortality at 90 days. An economic evaluation is embedded. The 65 trial received favourable ethical opinion from the South Central – Oxford C Research Ethics Committee and approval from the Health Research Authority. The results will be presented at national and international conferences and published in peer-reviewed medical journals.
AU - Richards-Belle,A
AU - Mouncey,PR
AU - Grieve,RD
AU - Harrison,DA
AU - Sadique,MZ
AU - Henry,D
AU - Whitman,C
AU - Camsooksai,J
AU - Gordon,AC
AU - Young,JD
AU - Rowan,KM
AU - Lamontagne,F
DO - 10.1177/1751143719870088
EP - 10
PY - 2019///
SN - 1751-1437
SP - 1
TI - Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial
T2 - Journal of the Intensive Care Society
UR - http://dx.doi.org/10.1177/1751143719870088
UR - https://journals.sagepub.com/doi/10.1177/1751143719870088
UR - http://hdl.handle.net/10044/1/75824
ER -