Imperial College London
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Professor Anthony Gordon

Faculty of Medicine, Department of Surgery & Cancer

Chair in Anaesthesia and Critical Care
 
 
 
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Contact

 

anthony.gordon

 
 
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Location

 

ICUQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Billot:2023,
author = {Billot, L and Cuthbertson, B and Gordon, A and Al-Beidh, F and Correa, M and Davis, J and Finfer, S and Glass, P and Goodman, F and Hammond, N and Iredell, J and Miller, J and Murthy, S and Rose, L and Seppelt, I and Taylor, C and Young, P and Myburgh, J and The, SuDDICU Investigators},
journal = {Critical Care and Resuscitation},
title = {Protocol summary and statistical analysis plan for the Selective Decontamination of the Digestive Tract in Intensive Care Units cross-over, cluster randomised controlled trial. (SuDDICU)},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:There is uncertainty whether the use of Selective Decontamination of the Digestive Tract (SDD) improves outcomes in ventilated patients in Intensive Care Units (ICUs) and whether SDD is associated with the development of antibiotic resistance. Objectives:To describe the study protocol and statistical analysis plan for the Selective Decontamination of the Digestive Tract in ICUs (SuDDICU) trial.Design, setting and participants:SuDDICU is an international, cross-over, cluster-randomised-controlled trial of mechanically ventilated patients in ICUs using two 12-month trial periods. Participating ICUs will implement either SDD plus standard care or standard care for each period. The SuDDICU drug intervention is an oral paste and gastric suspension of three antibiotics combined with a 4-day course of intravenous antibiotics. An observational ecological assessment will be conducted during the interventional periods and 5 surveillance periods. The trial will be conducted in 19 ICUs in Australia and 10 ICUs in Canada and the UK that will recruit 15000-17000 patients. Recruitment commenced in Australia in 2017. Outcomes:The primary outcome is all-cause hospital mortality. Secondary outcomes include duration of ventilation, ICU and hospital stay, the incidence of new antibiotic resistant organisms during the index ICU admission, changes in antibiotic resistant organism rates, incidence of new Clostridioides difficile infections and total antibiotic usage.Results and conclusions:SuDDICU will determine whether the use of SDD plus standard care is associated with a reduction in hospital mortality in ventilated ICU patients compared to standard care alone and will quantify the impact of the use of SDD on the development of antibiotic resistance. Trial registration:The trial is registered on the Australian and New Zealand Clinical Trials Registry (ACTRN12615000411549) and on ClinicalTrials.gov Registry (NCT02389036).
AU  - Billot,L
AU  - Cuthbertson,B
AU  - Gordon,A
AU  - Al-Beidh,F
AU  - Correa,M
AU  - Davis,J
AU  - Finfer,S
AU  - Glass,P
AU  - Goodman,F
AU  - Hammond,N
AU  - Iredell,J
AU  - Miller,J
AU  - Murthy,S
AU  - Rose,L
AU  - Seppelt,I
AU  - Taylor,C
AU  - Young,P
AU  - Myburgh,J
AU  - The,SuDDICU Investigators
PY  - 2023///
SN  - 1441-2772
TI  - Protocol summary and statistical analysis plan for the Selective Decontamination of the Digestive Tract in Intensive Care Units cross-over, cluster randomised controlled trial. (SuDDICU)
T2  - Critical Care and Resuscitation
ER  -
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