Imperial College London
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Professor Anthony Gordon

Faculty of Medicine, Department of Surgery & Cancer

Chair in Anaesthesia and Critical Care
 
 
 
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Contact

 

anthony.gordon

 
 
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Location

 

ICUQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maslove:2022:10.1038/s41591-022-01843-x,
author = {Maslove, DM and Tang, B and Shankar-Hari, M and Lawler, PR and Angus, DC and Baillie, JK and Baron, RM and Bauer, M and Buchman, TG and Calfee, CS and dos, Santos CC and Giamarellos-Bourboulis, EJ and Gordon, AC and Kellum, JA and Knight, JC and Leligdowicz, A and McAuley, DF and McLean, AS and Menon, DK and Meyer, NJ and Moldawer, LL and Reddy, K and Reilly, JP and Russell, JA and Sevransky, JE and Seymour, CW and Shapiro, NI and Singer, M and Summers, C and Sweeney, TE and Thompson, BT and van, der Poll T and Venkatesh, B and Walley, KR and Walsh, TS and Ware, LB and Wong, HR and Zador, ZE and Marshall, JC},
doi = {10.1038/s41591-022-01843-x},
journal = {Nature Medicine},
pages = {1141--1148},
title = {Redefining critical illness},
url = {http://dx.doi.org/10.1038/s41591-022-01843-x},
volume = {28},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Research and practice in critical care medicine have long been defined by syndromes, which, despite being clinically recognizable entities, are, in fact, loose amalgams of heterogeneous states that may respond differently to therapy. Mounting translational evidence—supported by research on respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—suggests that the current syndrome-based framework of critical illness should be reconsidered. Here we discuss recent findings from basic science and clinical research in critical care and explore how these might inform a new conceptual model of critical illness. De-emphasizing syndromes, we focus on the underlying biological changes that underpin critical illness states and that may be amenable to treatment. We hypothesize that such an approach will accelerate critical care research, leading to a richer understanding of the pathobiology of critical illness and of the key determinants of patient outcomes. This, in turn, will support the design of more effective clinical trials and inform a more precise and more effective practice at the bedside.
AU  - Maslove,DM
AU  - Tang,B
AU  - Shankar-Hari,M
AU  - Lawler,PR
AU  - Angus,DC
AU  - Baillie,JK
AU  - Baron,RM
AU  - Bauer,M
AU  - Buchman,TG
AU  - Calfee,CS
AU  - dos,Santos CC
AU  - Giamarellos-Bourboulis,EJ
AU  - Gordon,AC
AU  - Kellum,JA
AU  - Knight,JC
AU  - Leligdowicz,A
AU  - McAuley,DF
AU  - McLean,AS
AU  - Menon,DK
AU  - Meyer,NJ
AU  - Moldawer,LL
AU  - Reddy,K
AU  - Reilly,JP
AU  - Russell,JA
AU  - Sevransky,JE
AU  - Seymour,CW
AU  - Shapiro,NI
AU  - Singer,M
AU  - Summers,C
AU  - Sweeney,TE
AU  - Thompson,BT
AU  - van,der Poll T
AU  - Venkatesh,B
AU  - Walley,KR
AU  - Walsh,TS
AU  - Ware,LB
AU  - Wong,HR
AU  - Zador,ZE
AU  - Marshall,JC
DO  - 10.1038/s41591-022-01843-x
EP  - 1148
PY  - 2022///
SN  - 1078-8956
SP  - 1141
TI  - Redefining critical illness
T2  - Nature Medicine
UR  - http://dx.doi.org/10.1038/s41591-022-01843-x
UR  - https://www.nature.com/articles/s41591-022-01843-x
UR  - http://hdl.handle.net/10044/1/97654
VL  - 28
ER  -
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