Imperial College London
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DrArranHamlet

Faculty of Medicine, School of Public Health

Visiting Researcher
 
 
 
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Contact

 

arran.hamlet14

 
 
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Location

 

UG1247 Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jean:2020:10.1101/2020.07.09.20147355,
author = {Jean, K and Raad, H and Gaythorpe, KAM and Hamlet, A and Mueller, JE and Hogan, D and Mengistu, T and Whitaker, HJ and Garske, T and Hocine, MN},
doi = {10.1101/2020.07.09.20147355},
title = {Assessing the impact of preventive mass vaccination campaigns on yellow fever outbreaks in Africa : a population-level self-controlled case-series study},
url = {http://dx.doi.org/10.1101/2020.07.09.20147355},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>The Eliminate Yellow fever Epidemics (EYE) strategy was launched in 2017 in response to the resurgence of yellow fever in Africa and the Americas. The strategy relies on several vaccination activities, including preventive mass vaccination campaigns (PMVCs). However, by how much PMVCs decrease the risk of outbreak to occur has not yet been quantified.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We used the self-controlled case series (SCCS) method to assess the association between the occurrence of yellow fever outbreaks and the implementation of PMVCs at the province level in the African endemic region. As all time-invariant confounders are implicitly controlled for, the SCCS method is an alternative to classical cohort or case-control study designs when the risk of residual confounding is high.</jats:p><jats:p>The location and dates of outbreaks were identified from international epidemiological records, and information on PMVCs was provided by coordinators of vaccination activities and international funders. The study sample consisted of provinces that were both affected by an outbreak and targeted for a PMVC between 2005 and 2018. We compared the relative incidence of outbreaks before and after the implementation of a PMVC. The sensitivity of our estimates to a range of assumptions was explored, and the results of the SCCS method were compared to those obtained through a retrospective cohort study design. We further derived the number of yellow fever outbreaks that have been prevented by PMVCs.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The study sample consisted of 33 African provinces. Among these, outbreaks occurred during the pre-PMVC period in 26 (78.8%) provinces versus 7 (21.2%) occurring in the post-
AU  - Jean,K
AU  - Raad,H
AU  - Gaythorpe,KAM
AU  - Hamlet,A
AU  - Mueller,JE
AU  - Hogan,D
AU  - Mengistu,T
AU  - Whitaker,HJ
AU  - Garske,T
AU  - Hocine,MN
DO  - 10.1101/2020.07.09.20147355
PY  - 2020///
TI  - Assessing the impact of preventive mass vaccination campaigns on yellow fever outbreaks in Africa : a population-level self-controlled case-series study
UR  - http://dx.doi.org/10.1101/2020.07.09.20147355
ER  -
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