Imperial College London
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DrArranHamlet

Faculty of Medicine, School of Public Health

Visiting Researcher
 
 
 
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Contact

 

arran.hamlet14

 
 
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Location

 

UG1247 Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hamlet:2022:10.1186/s12916-022-02324-1,
author = {Hamlet, A and Dengela, D and Tongren, JE and Tadesse, FG and Bousema, T and Sinka, M and Seyoum, A and Irish, SR and Armistead, JS and Churcher, T},
doi = {10.1186/s12916-022-02324-1},
journal = {BMC Medicine},
title = {The potential impact of Anopheles stephensi establishment on the transmission of Plasmodium falciparum in Ethiopia and prospective control measures},
url = {http://dx.doi.org/10.1186/s12916-022-02324-1},
volume = {20},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundSub-Saharan Africa has seen substantial reductions in cases and deaths due to malaria over the past two decades. While this reduction is primarily due to an increasing expansion of interventions, urbanisation has played its part as urban areas typically experience substantially less malaria transmission than rural areas. However, this may be partially lost with the invasion and establishment of Anopheles stephensi. An. stephensi, the primary urban malaria vector in Asia, was first detected in Africa during 2012 in Djibouti and was subsequently identified in Ethiopia in 2016, and later in Sudan and Somalia. In Djibouti, malaria cases have increased 30-fold from 2012 to 2019 though the impact in the wider region remains unclear.MethodsHere we have adapted an existing model of mechanistic malaria transmission to estimate the increase in vector density required to explain the trends in malaria cases seen in Djibouti. To account for the observed plasticity in An. stephensi behaviour, and the unknowns of how it will establish in a novel environment, we sample behavioural parameters in order to account for a wide range of uncertainty. This quantification is then applied to Ethiopia, considering temperature-dependent extrinsic incubation periods, pre-existing vector-control interventions and Plasmodium falciparum prevalence in order to assess the potential impact of An. stephensi establishment on P. falciparum transmission. Following this, we estimate the potential impact of scaling up ITN (insecticide treated nets)/IRS (indoor residual spraying) and implementing piperonyl butoxide (PBO) ITNs and larval source management,, as well as their economic costs.ResultsWe estimate that annual P. falciparum malaria cases could increase by 50% (95% CI 14-90) if no additional interventions are implemented. The implementation of sufficient control measures to reduce malaria transmission to pre-stephensi levels will cost hundreds of millions of USD. ConclusionsSubstantial hete
AU  - Hamlet,A
AU  - Dengela,D
AU  - Tongren,JE
AU  - Tadesse,FG
AU  - Bousema,T
AU  - Sinka,M
AU  - Seyoum,A
AU  - Irish,SR
AU  - Armistead,JS
AU  - Churcher,T
DO  - 10.1186/s12916-022-02324-1
PY  - 2022///
SN  - 1741-7015
TI  - The potential impact of Anopheles stephensi establishment on the transmission of Plasmodium falciparum in Ethiopia and prospective control measures
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-022-02324-1
UR  - http://hdl.handle.net/10044/1/95813
VL  - 20
ER  -
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