Imperial College London

DrAshaPatel

Faculty of MedicineNational Heart & Lung Institute

Lecturer in Cell & Gene Therapy
 
 
 
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Contact

 

asha.patel

 
 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Summary

Asha Patel is lecturer [assistant Professor] in Cell & Gene Therapy at the NHLI, Imperial College London. Her research draws on expertise in stem cell differentiation, materials synthesis and pharmaceutical chemistry to develop novel biomaterials that either instruct stem cell behaviour or facilitate RNA delivery. A major theme of her research is to harness the potential of nucleic acid based therapeutics in regenerative medicine.

Asha joined the department in 2018 after completing 4 years of postdoctoral training as an EPSRC eterm fellow in the laboratories of Professors Daniel Anderson and Robert Langer at Massachusetts Institute of Technology, USA. Here, she developed biodegradable, non-viral vectors for the inhaled delivery of mRNA to the lung.

Asha graduated with a first class honours degree in Pharmacy from King's College London in 2006 and remains a member of the General Pharmaceutical Council and Royal Pharmaceutical Society. In 2014, she was awarded her PhD by the University of Nottingham as part of the CDT in Regenerative Medicine where she developed biomaterials that modulate human pluripotent stem cell and cardiomyocyte behaviour, under the guidance of Professors Chris Denning, Morgan Alexander and Martyn Davies.


Selected Publications

Journal Articles

Patel AK, Kaczmarek JC, Bose S, et al., 2019, Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium, Advanced Materials, ISSN:0935-9648, Pages:1805116-1805116

Smith JGW, Owen T, Bhagwan JR, et al., 2018, Isogenic pairs of hiPSC-CMs with hypertrophic cardiomyopathy/LVNC-associated ACTC1 E99K mutation unveil differential functional deficits, Stem Cell Reports, Vol:11, ISSN:2213-6711, Pages:1226-1243

Delcassian D, Patel AK, Cortinas AB, et al., 2018, Drug delivery across length scales., J Drug Target, Pages:1-15

Kaczmarek JC, Patel AK, Kauffman KJ, et al., 2016, Polymer-lipid nanoparticles for systemic delivery of mRNA to the lungs, Angewandte Chemie International Edition, Vol:55, ISSN:1521-3757, Pages:13808-13812

Patel AK, Tibbitt MW, Celiz AD, et al., 2016, High throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State & Materials Science, Vol:20, ISSN:1359-0286, Pages:202-211

Patel AK, Celiz AD, Rajamohan D, et al., 2015, A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays, Biomaterials, Vol:61, ISSN:0142-9612, Pages:257-265

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