Asha Patel is lecturer [assistant Professor] in Cell & Gene Therapy at the NHLI, Imperial College London. Her research draws on multidisciplinary approaches including nanotechnology, materials science, biochemistry and pharmaceutics to harness the potential of nucleic acid based therapeutics. A major theme of her research focuses on the need to develop safe and effective vehicles for the delivery of nucleic acid to target cells in the body and ex vivo, using clinically relevant administration routes.
Asha joined the department in 2018 after completing 4 years of postdoctoral training as an EPSRC eterm fellow in the laboratories of Professors Daniel Anderson and Robert Langer at the Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT). Here, she developed biodegradable materials for the inhaled delivery of mRNA to the lung.
Asha graduated with a first class honours degree in Pharmacy from King's College London and has extensive professional experience, she is a member of the General Pharmaceutical Council. In 2014, she was awarded her PhD by the University of Nottingham where she developed synthetic biomaterials that modulate human pluripotent stem cell and cardiomyocyte behaviour, under the guidance of Professors Chris Denning, Morgan Alexander and Martyn Davies.
et al., Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium, Advanced Materials, ISSN:0935-9648, Pages:1805116-1805116
et al., 2018, Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTCI E99K Mutation Unveil Differential Functional Deficits, Stem Cell Reports, Vol:11, ISSN:2213-6711, Pages:1226-1243
et al., 2016, Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs, Angewandte Chemie - International Edition, Vol:55, ISSN:1433-7851, Pages:13808-13812
et al., 2016, High throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State & Materials Science, Vol:20, ISSN:1359-0286, Pages:202-211
et al., 2015, A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays, Biomaterials, Vol:61, ISSN:0142-9612, Pages:257-265