Imperial College London
Portrait Picture

Dr Asha K. Patel

Faculty of Medicine, National Heart & Lung Institute

Lecturer in Cell & Gene Therapy
 
 
 
//

Contact

 

asha.patel

 
 
//

Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Kaczmarek:2016:10.1002/anie.201608450,
author = {Kaczmarek, JC and Patel, AK and Kauffman, KJ and Fenton, OS and Webber, MJ and Heartlein, MW and DeRosa, F and Anderson, DG},
doi = {10.1002/anie.201608450},
journal = {Angewandte Chemie International Edition},
pages = {13808--13812},
title = {Polymer-lipid nanoparticles for systemic delivery of mRNA to the lungs},
url = {http://dx.doi.org/10.1002/anie.201608450},
volume = {55},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors for safe and effective delivery. Synthetic nanoparticle vectors composed of poly(βamino esters) (PBAEs) and nucleic acids have previously demonstrated potential utility for local delivery applications. To expand this potential utility to include systemic delivery of mRNA, hybrid polymer–lipid nanoformulations for systemic delivery to the lungs were developed. Through coformulation of PBAEs with lipid–polyethylene glycol (PEG), mRNA formulations were developed with increased serum stability and increased invitro potency. The formulations were capable of functional delivery of mRNA to the lungs after intravenous administration in mice. To our knowledge, this is the first report of the systemic administration of mRNA for delivery to the lungs using degradable polymer–lipid nanoparticles.
AU  - Kaczmarek,JC
AU  - Patel,AK
AU  - Kauffman,KJ
AU  - Fenton,OS
AU  - Webber,MJ
AU  - Heartlein,MW
AU  - DeRosa,F
AU  - Anderson,DG
DO  - 10.1002/anie.201608450
EP  - 13812
PY  - 2016///
SN  - 1521-3757
SP  - 13808
TI  - Polymer-lipid nanoparticles for systemic delivery of mRNA to the lungs
T2  - Angewandte Chemie International Edition
UR  - http://dx.doi.org/10.1002/anie.201608450
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387024200025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71227
VL  - 55
ER  -
Download