Imperial College London
Portrait Picture

Dr Ben Almquist FIMMM

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 6494b.almquist Website

 
 
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Location

 

413Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Choi:2019:10.1002/adma.201803549,
author = {Choi, KY and Han, HS and Lee, ES and Shin, JM and Almquist, B and Lee, DS and Park, JH},
doi = {10.1002/adma.201803549},
journal = {Advanced Materials},
title = {Hyaluronic acid-based activatable nanomaterials for stimuli-responsive imaging and therapeutics: beyond CD44-mediated drug delivery},
url = {http://dx.doi.org/10.1002/adma.201803549},
volume = {31},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is a rapidly increasing interest in developing stimuli-responsive nanomaterials for treating a variety of diseases.  By enabling the activation of function locally at the sites of interest, it is possible to increase therapeutic efficacy significantly while simultaneously reducing adverse side effects.  While there are many sophisticated nanomaterials available, they are many times highly complex and not easily transferrable to industrial scales and clinical settings.  However, hyaluronic acid-based nanomaterials offer a compelling strategy for reducing the complexity of nanomaterials while retaining several desirable benefits such as active targeting and stimuli-responsive degradation.  In this report, we cover the basic properties of hyaluronic acid, its binding partners, and natural routes for degradation by hyaluronidases—hyaluronic acid-degrading enzymes—and oxidative stresses.  We then cover recent advances in designing hyaluronic acid-based, actively targeted, hyaluronidase- or reactive oxygen species-responsive nanomaterials for both diagnostic imaging and therapeutic delivery that go beyond merely the classical targeting of CD44.
AU  - Choi,KY
AU  - Han,HS
AU  - Lee,ES
AU  - Shin,JM
AU  - Almquist,B
AU  - Lee,DS
AU  - Park,JH
DO  - 10.1002/adma.201803549
PY  - 2019///
SN  - 0935-9648
TI  - Hyaluronic acid-based activatable nanomaterials for stimuli-responsive imaging and therapeutics: beyond CD44-mediated drug delivery
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.201803549
UR  - http://hdl.handle.net/10044/1/66918
VL  - 31
ER  -
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