Imperial College London
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Dr Ben Almquist FIMMM

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 6494b.almquist Website

 
 
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Location

 

413Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stejskalova:2021:10.1016/j.actbio.2021.04.032,
author = {Stejskalova, A and Vankelecom, H and Sourouni, M and Ho, M and Götte, M and Almquist, B},
doi = {10.1016/j.actbio.2021.04.032},
journal = {Acta Biomaterialia},
pages = {288--312},
title = {In vitro modelling of the physiological and diseased female reproductive system},
url = {http://dx.doi.org/10.1016/j.actbio.2021.04.032},
volume = {132},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The maladies affecting the female reproductive tract (FRT) range from infections to endometriosis to carcinomas. In vitro models of the FRT play an increasingly important role in both basic and translational research, since the anatomy and physiology of the FRT of humans and other primates differ significantly from most of the commonly used animal models, including rodents. Using organoid culture to study the FRT has overcome the longstanding hurdle of maintaining epithelial phenotype in culture.  Both ECM-derived and engineered materials have proved critical for maintaining a physiological phenotype of FRT cells in vitro by providing the requisite 3D environment, ligands, and architecture. Advanced materials have also enabled the systematic study of factors contributing to the invasive metastatic processes. Meanwhile, microphysiological devices make it possible to incorporate physical signals such as flow and cyclic exposure to hormones. Going forward, advanced materials compatible with hormones and optimised to support FRT-derived cells' long-term growth, will play a key role in addressing the diverse array of FRT pathologies and lead to impactful new treatments that support the improvement of women's health.
AU  - Stejskalova,A
AU  - Vankelecom,H
AU  - Sourouni,M
AU  - Ho,M
AU  - Götte,M
AU  - Almquist,B
DO  - 10.1016/j.actbio.2021.04.032
EP  - 312
PY  - 2021///
SN  - 1742-7061
SP  - 288
TI  - In vitro modelling of the physiological and diseased female reproductive system
T2  - Acta Biomaterialia
UR  - http://dx.doi.org/10.1016/j.actbio.2021.04.032
UR  - https://www.sciencedirect.com/science/article/pii/S1742706121002695?via%3Dihub
UR  - http://hdl.handle.net/10044/1/89302
VL  - 132
ER  -
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