Summary
I use a novel combination of experimental, mathematical and bioinformatic techniques to investigate cell-mediated immunity. My aim is to develop a predictive mathematical model of the human in vivo CD8+ T cell response in order to prevent and alleviate viral infection.
Members of the GrouP
Current
David Vickers
Recent
Nafisa-Katrin Seich al Basatena
Ulrich Kadolsky (u.kadolsky01@imperial.ac.uk)
Aidan Macnamara (aidan.macnamara@gmail.com)
Sukhdeep Singh (sukhdeepsingh.bio@googlemail.com)
Background
My initial training was in theoretical physics. I have a BSc in Physics (1st class hons. University College London), an MSc in Mathematics (distinction, Imperial College London) and a PhD in Theoretical Particle Physics (title: "Non Commutative Geometry", University of Durham). I then worked as a mathematical modeller for the UK government for 2 years before crossing disciplines to Mathematical Immunology. I held a Wellcome Trust Fellowship at Imperial College London and then a Leverhulme Trust Fellowship at the University of Oxford before returning to Imperial as a lecturer.
For research interests and selected publications please see my group webpage.
oPPORTUNITIES
Funded PhD positions available:
Please contact me if you wish to discuss these opportunities further.
software
Publications
Journals
Laydon DJ, Sunkara V, Boelen L, et al., 2020, The relative contributions of infectious and mitotic spread to HTLV-1 persistence, Plos Computational Biology, Vol:16, ISSN:1553-734X
Costa Del Amo P, Debebe B, Razavi-Mohseni M, et al., 2020, The rules of human T cell fate in vivo, Frontiers in Immunology, Vol:11, ISSN:1664-3224
Debebe BJ, Boelen L, Lee JC, et al., 2020, Identifying the immune interactions underlying HLA class I disease associations, Elife, Vol:9, ISSN:2050-084X
Macallan D, Busch R, Asquith B, 2019, Current estimates of T cell kinetics in humans, Current Opinion in Systems Biology, Vol:18, ISSN:2452-3100, Pages:77-86
Boelen L, Debebe B, Silveira M, et al., 2018, Inhibitory killer-cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV and HTLV-1, Science Immunology, Vol:3, ISSN:2470-9468