Imperial College London
Alternate

Dr Becca Asquith

Faculty of Medicine, Department of Infectious Disease

Professor of Mathematical Immunology
 
 
 
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Contact

 

+44 (0)20 7594 3731b.asquith

 
 
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Location

 

112Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ahemd:2020:10.1016/j.celrep.2020.108501,
author = {Ahemd, R and Miners, KL and Lahoz-Beneytez, J and Jones, RE and Roger, L and Baboonian, C and Zhang, Y and Wang, ECY and Hellerstein, MK and McCune, JM and Baird, DM and Macallan, DC and Asquith, R and Ladell, K},
doi = {10.1016/j.celrep.2020.108501},
journal = {Cell Reports},
pages = {e1--e5},
title = {CD57+ memory T cells proliferate in vivo},
url = {http://dx.doi.org/10.1016/j.celrep.2020.108501},
volume = {33},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A  central  paradigm  in  the  field  of  lymphocyte  biology  asserts  that  replicatively  senescent memory   T   cells   express   the   carbohydrate   epitope   CD57. These   cells   nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation.  We used in  vivo deuterium  labeling  and ex  vivo analyses  of  telomere  length,  telomerase activity, and intracellular expression of the cell-cycle marker Ki67 to distinguish between two non-exclusive  scenarios:  (i)  CD57+memory  T  cells do  not  proliferate  and  instead arise  via phenotypic transition from the CD57−memory T cell pool; and/or (ii) CD57+memory T cells self-renew via intracompartmental proliferation. Our  results  provide  compelling  evidence  in favor of  the  latter  scenario  and  further  suggest  in  conjunction  with  mathematical  modeling that  self-renewal isby  far the  most  abundant  source  of  newly  generated  CD57+memory T cells. Immunological memory therefore appears to be intrinsically sustainable among highly differentiated subsets of T cells that express CD57.
AU  - Ahemd,R
AU  - Miners,KL
AU  - Lahoz-Beneytez,J
AU  - Jones,RE
AU  - Roger,L
AU  - Baboonian,C
AU  - Zhang,Y
AU  - Wang,ECY
AU  - Hellerstein,MK
AU  - McCune,JM
AU  - Baird,DM
AU  - Macallan,DC
AU  - Asquith,R
AU  - Ladell,K
DO  - 10.1016/j.celrep.2020.108501
EP  - 5
PY  - 2020///
SN  - 2211-1247
SP  - 1
TI  - CD57+ memory T cells proliferate in vivo
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2020.108501
UR  - https://www.sciencedirect.com/science/article/pii/S221112472031490X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/84826
VL  - 33
ER  -
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