Imperial College London
Alternate

Dr Becca Asquith

Faculty of Medicine, Department of Infectious Disease

Professor of Mathematical Immunology
 
 
 
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Contact

 

+44 (0)20 7594 3731b.asquith

 
 
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Location

 

112Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Elemans:2014:10.1371/journal.pcbi.1003534,
author = {Elemans, M and Florins, A and Willems, L and Asquith, B},
doi = {10.1371/journal.pcbi.1003534},
journal = {PLOS COMPUTATIONAL BIOLOGY},
title = {Rates of CTL Killing in Persistent Viral Infection In Vivo},
url = {http://dx.doi.org/10.1371/journal.pcbi.1003534},
volume = {10},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The CD8+ cytotoxic T lymphocyte (CTL) response is an important defence against viral invasion. Although CTL-mediated cytotoxicity has been widely studied for many years, the rate at which virus-infected cells are killed in vivo by the CTL response is poorly understood. To date the rate of CTL killing in vivo has been estimated for three virus infections but the estimates differ considerably, and killing of HIV-1-infected cells was unexpectedly low. This raises questions about the typical anti-viral capability of CTL and whether CTL killing is abnormally low in HIV-1. We estimated the rate of killing of infected cells by CD8+ T cells in two distinct persistent virus infections: sheep infected with Bovine Leukemia Virus (BLV) and humans infected with Human T Lymphotropic Virus type 1 (HTLV-1) which together with existing data allows us to study a total of five viruses in parallel. Although both BLV and HTLV-1 infection are characterised by large expansions of chronically activated CTL with immediate effector function ex vivo and no evidence of overt immune suppression, our estimates are at the lower end of the reported range. This enables us to put current estimates into perspective and shows that CTL killing of HIV-infected cells may not be atypically low. The estimates at the higher end of the range are obtained in more manipulated systems and may thus represent the potential rather than the realised CTL efficiency.
AU  - Elemans,M
AU  - Florins,A
AU  - Willems,L
AU  - Asquith,B
DO  - 10.1371/journal.pcbi.1003534
PY  - 2014///
SN  - 1553-734X
TI  - Rates of CTL Killing in Persistent Viral Infection In Vivo
T2  - PLOS COMPUTATIONAL BIOLOGY
UR  - http://dx.doi.org/10.1371/journal.pcbi.1003534
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336507500006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/61105
VL  - 10
ER  -
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