SUMMARY
What constitutes an effective CD8+ T cell immune response in humans? And does CD8+ T cell efficacy determine human health? To understand human immunity we need to study humans. However, the work that can be performed in humans is very limited. I am developing alternative approaches that use theoretical techniques (mathematics, statistics and bioinformatics) to interrogate, model and analyse the experiments we can do -experiments of nature or minimally-invasive experiments- to obtain the information we need. My goal is to develop a predictive, quantitative understanding of the human T cell response.
Guest Lectures
Jacques Monod Conference ‘A matter of scale: Within-host and between-host processes driving coevolution with parasites’ . Invited guest lecture, French Centre National de la Recherche Scientifique (CNRS), France, 2022
British Society of Immunology Annual Congressinvited lecture, 2021
Canadian Mathematical Society Winter Meeting, McGill University, Canada, 2020
4th Annual Symposium on Physical Concepts and Computational Models in Immunology, University of Cologne, Cologne, 2020
Control and Decision Making in Immune Repertoire Dynamics, Dresden, Dresden, 2020
The 3rd international meeting on stochasticity and control in immune repertoires, Yale/ University of Haifa/ Hebrew University, Connecticut/Haifa/Jerusalem, 2019
Invited guest lecture Paris Viral Dynamics 2019, Inserm and Université Paris Diderot, Paris, 2019
Invited guest speaker at CompBioMed Conference 2019, KCL/University of Southampton, 2019
Otto Wolff Lecture, University College London, London, 2019
Utrecht Winter Master Class, University of Utrecht, Utrecht, Netherlands, 2019
Research Student Supervision
Beneytez,JL, PhD
Burzynski,P, MRes: Kinetics of Stem cell memory T cells
Costa del Amo,P, Quantifying lymphocyte dynamics
Hogan,M, UROP internship
Hustin,L, UROP Internship
Jonas,M, PhD
Kaur,C, Cell differentiation pathways in humans
Koftori,D, Identifying TSCM subpopulations
Mackerodt,J, Topology of T cell Differentiation
Mohseni,M, Summer internship
Mora,L, iKIRs in autoimmunity & cancer
Padrosa,D, MRes: iKIRs and T cell Survival