Imperial College London
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Prof Benjamin Barratt

Faculty of Medicine, School of Public Health

Professor in Environmental Exposures and Public Health
 
 
 
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Contact

 

+44 (0)20 7594 2409b.barratt Website

 
 
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Location

 

UREN.1023Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Evangelopoulos:2021:10.1183/13993003.03432-2020,
author = {Evangelopoulos, D and Chatzidiakou, L and Walton, H and Katsouyanni, K and Kelly, FJ and Quint, JK and Jones, RL and Barratt, B},
doi = {10.1183/13993003.03432-2020},
journal = {European Respiratory Journal},
title = {Personal exposure to air pollution and respiratory health of COPD patients in London},
url = {http://dx.doi.org/10.1183/13993003.03432-2020},
volume = {58},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Previous studies have investigated the effects of air pollution on chronic obstructive pulmonary disease (COPD) patients using either fixed site measurements or a limited number of personal measurements, usually for one pollutant and a short time period. These limitations may introduce bias and distort the epidemiological associations as they do not account for all the potential sources or the temporal variability of pollution.We used detailed information on individuals' exposure to various pollutants measured at fine spatio-temporal scale to obtain more reliable effect estimates. A panel of 115 patients was followed up for an average continuous period of 128days carrying a personal monitor specifically designed for this project that measured temperature, PM10, PM2.5, NO2, NO, CO and O3 at one-minute time resolution. Each patient recorded daily information on respiratory symptoms and measured peak expiratory flow (PEF). A pulmonologist combined related data to define a binary variable denoting an "exacerbation". The exposure-response associations were assessed with mixed-effects models.We found that gaseous pollutants were associated with a deterioration in patients' health. We observed an increase of 16.4% (95% confidence interval: 8.6-24.6%), 9.4% (5.4-13.6%) and 7.6% (3.0-12.4%) in the odds of exacerbation for an interquartile range increase in NO2, NO and CO respectively. Similar results were obtained for cough and sputum. O3 was found to have adverse associations with PEF and breathlessness. No association was observed between particles and any outcome.Our findings suggest that, when considering total personal exposure to air pollutants, mainly the gaseous pollutants affect COPD patients' health.
AU  - Evangelopoulos,D
AU  - Chatzidiakou,L
AU  - Walton,H
AU  - Katsouyanni,K
AU  - Kelly,FJ
AU  - Quint,JK
AU  - Jones,RL
AU  - Barratt,B
DO  - 10.1183/13993003.03432-2020
PY  - 2021///
SN  - 0903-1936
TI  - Personal exposure to air pollution and respiratory health of COPD patients in London
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.03432-2020
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33542053
UR  - https://erj.ersjournals.com/content/early/2020/12/17/13993003.03432-2020
UR  - http://hdl.handle.net/10044/1/86276
VL  - 58
ER  -
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