Imperial College London
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ProfessorBobBrown

Faculty of Medicine, Department of Surgery & Cancer

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 1804b.brown Website

 
 
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Assistant

 

Ms Sophie Lions +44 (0)20 7594 2792

 
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Location

 

1 007Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Scott:2019:10.1136/gutjnl-2019-318556,
author = {Scott, AJ and Alexander, JL and Merrifield, CA and Cunningham, D and Jobin, C and Brown, R and Alverdy, J and O'Keefe, SJ and Gaskins, HR and Teare, J and Yu, J and Hughes, DJ and Verstraelen, H and Burton, J and O'Toole, PW and Rosenberg, DW and Marchesi, JR and Kinross, JM},
doi = {10.1136/gutjnl-2019-318556},
journal = {Gut},
pages = {1624--1632},
title = {International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis},
url = {http://dx.doi.org/10.1136/gutjnl-2019-318556},
volume = {68},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis.Design International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research.Results Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field.The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis.Conclusion Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.
AU  - Scott,AJ
AU  - Alexander,JL
AU  - Merrifield,CA
AU  - Cunningham,D
AU  - Jobin,C
AU  - Brown,R
AU  - Alverdy,J
AU  - O'Keefe,SJ
AU  - Gaskins,HR
AU  - Teare,J
AU  - Yu,J
AU  - Hughes,DJ
AU  - Verstraelen,H
AU  - Burton,J
AU  - O'Toole,PW
AU  - Rosenberg,DW
AU  - Marchesi,JR
AU  - Kinross,JM
DO  - 10.1136/gutjnl-2019-318556
EP  - 1632
PY  - 2019///
SN  - 0017-5749
SP  - 1624
TI  - International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis
T2  - Gut
UR  - http://dx.doi.org/10.1136/gutjnl-2019-318556
UR  - http://hdl.handle.net/10044/1/70313
VL  - 68
ER  -
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