Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Professor of Molecular Membrane Biology



+44 (0)20 7594 3004b.byrne Website




504Sir Ernst Chain BuildingSouth Kensington Campus






BibTex format

author = {Hussain, H and Helton, T and Du, Y and Mortensen, JS and Hariharan, P and Ehsan, M and Byrne, B and Loland, CJ and Kobilka, BK and Guan, L and Chae, PS},
doi = {10.1039/c8an01408f},
journal = {The Analyst},
pages = {5702--5710},
title = {A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability},
url = {},
volume = {143},
year = {2018}

RIS format (EndNote, RefMan)

AB - The study of membrane proteins is extremely challenging, mainly because of the incompatibility of the hydrophobic surfaces of membrane proteins with an aqueous medium. Detergents are essential agents used to maintain membrane protein stability in non-native environments. However, conventional detergents fail to stabilize the native structures of many membrane proteins. Development of new amphipathic agents with enhanced efficacy for membrane protein stabilization is necessary to address this important problem. We have designed and synthesized linear and branched mannitol-based amphiphiles (MNAs), and comparative studies showed that most of the branched MNAs had advantages over the linear agents in terms of membrane protein stability. In addition, a couple of the new MNAs displayed favorable behaviors compared to n-dodecyl-β-D-maltoside and the previously developed MNAs in maintaining the native protein structures, indicating potential utility of these new agents in membrane protein study.
AU - Hussain,H
AU - Helton,T
AU - Du,Y
AU - Mortensen,JS
AU - Hariharan,P
AU - Ehsan,M
AU - Byrne,B
AU - Loland,CJ
AU - Kobilka,BK
AU - Guan,L
AU - Chae,PS
DO - 10.1039/c8an01408f
EP - 5710
PY - 2018///
SN - 0003-2654
SP - 5702
TI - A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability
T2 - The Analyst
UR -
UR -
UR -
VL - 143
ER -