Imperial College London

ProfessorBernadetteByrne

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Molecular Membrane Biology
 
 
 
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Contact

 

+44 (0)20 7594 3004b.byrne Website

 
 
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Location

 

504Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ehsan:2019:10.1002/asia.201900224,
author = {Ehsan, M and Kumar, A and Mortensen, JS and Du, Y and Hariharan, P and Kumar, KK and Ha, B and Byrne, B and Guan, L and Kobilka, BK and Loland, CJ and Chae, PS},
doi = {10.1002/asia.201900224},
journal = {Chemistry: An Asian Journal},
pages = {1926--1931},
title = {Self-assembly behaviors of a penta-phenylene maltoside and its application for membrane protein study},
url = {http://dx.doi.org/10.1002/asia.201900224},
volume = {14},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - We prepared an amphiphile with a penta-phenylene lipophilic group and a branched trimaltoside head group. This new agent, designated penta-phenylene maltoside (PPM), showed a marked tendency to self-assembly into micelles via strong aromatic-aromatic interactions in aqueous media, as evidenced by 1 HNMR spectroscopy and fluorescence studies. When utilized for membrane protein studies, this new agent was superior to DDM, a gold standard conventional detergent, in stabilizing multiple proteins long term. The ability of this agent to form aromatic-aromatic interactions is likely responsible for enhanced protein stabilization when associated with a target membrane protein.
AU - Ehsan,M
AU - Kumar,A
AU - Mortensen,JS
AU - Du,Y
AU - Hariharan,P
AU - Kumar,KK
AU - Ha,B
AU - Byrne,B
AU - Guan,L
AU - Kobilka,BK
AU - Loland,CJ
AU - Chae,PS
DO - 10.1002/asia.201900224
EP - 1931
PY - 2019///
SN - 1861-471X
SP - 1926
TI - Self-assembly behaviors of a penta-phenylene maltoside and its application for membrane protein study
T2 - Chemistry: An Asian Journal
UR - http://dx.doi.org/10.1002/asia.201900224
UR - https://www.ncbi.nlm.nih.gov/pubmed/30969484
UR - http://hdl.handle.net/10044/1/76824
VL - 14
ER -