Imperial College London

ProfessorBernadetteByrne

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Molecular Membrane Biology
 
 
 
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Contact

 

+44 (0)20 7594 3004b.byrne Website

 
 
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Location

 

504Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hussain:2017:10.1038/s41598-017-03809-3,
author = {Hussain, H and Mortensen, JS and Du, Y and Santillan, C and Ribeiro, O and Go, J and Hariharan, P and Loland, CJ and Guan, L and Kobilka, BK and Byrne, B and Chae, PS},
doi = {10.1038/s41598-017-03809-3},
journal = {Scientific Reports},
title = {Tandem malonate-based glucosides (TMGs) for membrane protein structural studies},
url = {http://dx.doi.org/10.1038/s41598-017-03809-3},
volume = {7},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - High-resolution membrane protein structures are essential for understanding the molecular basis of diverse biological events and important in drug development. Detergents are usually used to extract these bio-macromolecules from the membranes and maintain them in a soluble and stable state in aqueous solutions for downstream characterization. However, many eukaryotic membrane proteins solubilized in conventional detergents tend to undergo structural degradation, necessitating the development of new amphiphilic agents with enhanced properties. In this study, we designed and synthesized a novel class of glucoside amphiphiles, designated tandem malonate-based glucosides (TMGs). A few TMG agents proved effective at both stabilizing a range of membrane proteins and extracting proteins from the membrane environment. These favourable characteristics, along with synthetic convenience, indicate that these agents have potential in membrane protein research.
AU - Hussain,H
AU - Mortensen,JS
AU - Du,Y
AU - Santillan,C
AU - Ribeiro,O
AU - Go,J
AU - Hariharan,P
AU - Loland,CJ
AU - Guan,L
AU - Kobilka,BK
AU - Byrne,B
AU - Chae,PS
DO - 10.1038/s41598-017-03809-3
PY - 2017///
SN - 2045-2322
TI - Tandem malonate-based glucosides (TMGs) for membrane protein structural studies
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-017-03809-3
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403840000035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/50202
VL - 7
ER -