Imperial College London
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ProfessorBernadetteByrne

Faculty of Natural Sciences, Department of Life Sciences

Associate Dean (Equality, Diversity and Inclusion) for FoNS
 
 
 
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Contact

 

+44 (0)20 7594 3004b.byrne Website

 
 
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Location

 

504Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Das:2018:10.1002/cbic.201800388,
author = {Das, M and Du, Y and Mortensen, JS and Hariharan, P and Lee, HS and Byrne, B and Loland, CJ and Guan, L and Kobilka, BK and Chae, PS},
doi = {10.1002/cbic.201800388},
journal = {ChemBioChem: a European journal of chemical biology},
pages = {2225--2232},
title = {Rationally engineered tandem facial amphiphiles for improved membrane protein stabilization efficacy},
url = {http://dx.doi.org/10.1002/cbic.201800388},
volume = {19},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A new family of tandem facial glucosides/maltosides (TFGs/TFMs) for membrane protein manipulation was prepared. The best detergent varied depending on the hydrophobic thickness of the target protein, but etherbased TFMs (TFMC0E, TFMC3E, and TFMC5E) were notable for their ability to confer higher membrane protein stability than the previously developed amidebased TFA1 (P.S. Chae, K. Gotfryd, J. Pacyna, L.J.W. Miercke, S.G.F. Rasmussen, R.A. Robbins, R.R. Rana, C.J. Loland, B. Kobilka, R. Stroud, B. Byrne, U. Gether, S.H. Gellman, J. Am. Chem. Soc. 2010, 132, 16750–16752). Thus, this study not only introduces novel agents with the potential to be used in membrane protein research but also highlights the importance of both the hydrophobic length and linker functionality of the detergent in stabilizing membrane proteins.
AU  - Das,M
AU  - Du,Y
AU  - Mortensen,JS
AU  - Hariharan,P
AU  - Lee,HS
AU  - Byrne,B
AU  - Loland,CJ
AU  - Guan,L
AU  - Kobilka,BK
AU  - Chae,PS
DO  - 10.1002/cbic.201800388
EP  - 2232
PY  - 2018///
SN  - 1439-4227
SP  - 2225
TI  - Rationally engineered tandem facial amphiphiles for improved membrane protein stabilization efficacy
T2  - ChemBioChem: a European journal of chemical biology
UR  - http://dx.doi.org/10.1002/cbic.201800388
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000447635300014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/76820
VL  - 19
ER  -
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