Imperial College London
Ben Creagh-Brown

Ben Creagh-Brown

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

b.creagh-brown08

 
 
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Location

 

Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lambden:2018:10.1186/s13054-018-2102-1,
author = {Lambden, S and Creagh-Brown, BC and Hunt, J and Summers, C and Forni, LG},
doi = {10.1186/s13054-018-2102-1},
journal = {Critical Care},
title = {Definitions and pathophysiology of vasoplegic shock},
url = {http://dx.doi.org/10.1186/s13054-018-2102-1},
volume = {22},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Vasoplegia is the syndrome of pathological low systemic vascular resistance, the dominant clinical feature of which is reduced blood pressure in the presence of a normal or raised cardiac output. The vasoplegic syndrome is encountered in many clinical scenarios, including septic shock, post-cardiac bypass and after surgery, burns and trauma, but despite this, uniform clinical definitions are lacking, which renders translational research in this area challenging. We discuss the role of vasoplegia in these contexts and the criteria that are used to describe it are discussed. Intrinsic processes which may drive vasoplegia, such as nitric oxide, prostanoids, endothelin-1, hydrogen sulphide and reactive oxygen species production, are reviewed and potential for therapeutic intervention explored. Extrinsic drivers, including those mediated by glucocorticoid, catecholamine and vasopressin responsiveness of the blood vessels, are also discussed. The optimum balance between maintaining adequate systemic vascular resistance against the potentially deleterious effects of treatment with catecholamines is as yet unclear, but development of novel vasoactive agents may facilitate greater understanding of the role of the differing pathways in the development of vasoplegia. In turn, this may provide insights into the best way to care for patients with this common, multifactorial condition.
AU  - Lambden,S
AU  - Creagh-Brown,BC
AU  - Hunt,J
AU  - Summers,C
AU  - Forni,LG
DO  - 10.1186/s13054-018-2102-1
PY  - 2018///
SN  - 1364-8535
TI  - Definitions and pathophysiology of vasoplegic shock
T2  - Critical Care
UR  - http://dx.doi.org/10.1186/s13054-018-2102-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29980217
UR  - http://hdl.handle.net/10044/1/61603
VL  - 22
ER  -
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