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@article{Nikolakopoulou:2019:10.2217/bmm-2018-0238,
author = {Nikolakopoulou, Z and Hector, LR and Creagh-Brown, BC and Evans, T and Quinlan, G and Burke-Gaffney, A},
doi = {10.2217/bmm-2018-0238},
journal = {Biomarkers in Medicine},
pages = {205--218},
title = {Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery},
url = {http://dx.doi.org/10.2217/bmm-2018-0238},
volume = {13},
year = {2019}
}

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TY  - JOUR
AB  - We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acutekidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass(CPB). Patients & methods: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB. Results: All markers increased significantly post-CPBwith S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKIwithin 7 days. S100A8/A9 had good prognostic utility for AKI, with an area under the receiver operating characteristic curve of 0.81 (95% CI: 0.676–0.949) and a cut-off value of 10.6 μg/ml (85.7% sensitivityand 75% specificity) irrespective of age. Conclusion: Plasma S100A8/A9 levels immediately after cardiacsurgery, can predict onset of AKI, irrespective of age.
AU  - Nikolakopoulou,Z
AU  - Hector,LR
AU  - Creagh-Brown,BC
AU  - Evans,T
AU  - Quinlan,G
AU  - Burke-Gaffney,A
DO  - 10.2217/bmm-2018-0238
EP  - 218
PY  - 2019///
SN  - 1752-0363
SP  - 205
TI  - Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery
T2  - Biomarkers in Medicine
UR  - http://dx.doi.org/10.2217/bmm-2018-0238
UR  - http://hdl.handle.net/10044/1/66739
VL  - 13
ER  -

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