Imperial College London
Ben Creagh-Brown

Ben Creagh-Brown

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

b.creagh-brown08

 
 
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Location

 

Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mazzinari:2021:10.1186/s12871-021-01268-y,
author = {Mazzinari, G and Serpa, Neto A and Hemmes, SNT and Hedenstierna, G and Jaber, S and Hiesmayr, M and Hollmann, MW and Mills, GH and Vidal, Melo MF and Pearse, RM and Putensen, C and Schmid, W and Severgnini, P and Wrigge, H and Cambronero, OD and Ball, L and de, Abreu MG and Pelosi, P and Schultz, MJ and LAS, VEGAS studyinvestigators and PROtective, VEntilation NETwork and Clinical, Trial Network of the European Society of Anaesthesiology},
doi = {10.1186/s12871-021-01268-y},
journal = {BMC Anesthesiol},
title = {The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study.},
url = {http://dx.doi.org/10.1186/s12871-021-01268-y},
volume = {21},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time-weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. METHODS: Posthoc retrospective propensity score-weighted cohort analysis of patients undergoing open or closed abdominal surgery in the 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events. RESULTS: The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTW was not different between groups. The association of ΔPTW with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P <  0.001 versus 1.05 [95%CI 1.05 to 1.05], P <  0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P <  0.001). The association of ΔPTW with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12- to 1.14], P <  0.001 versus 1.07 [95%CI 1.05 to 1.10], P <  0.001; risk difference 0.05 [95%CI 0.030.07], P <  0.001). CONCLUSIONS: ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery. TRIAL REGISTRATION: LAS VEGAS was registered at cl
AU  - Mazzinari,G
AU  - Serpa,Neto A
AU  - Hemmes,SNT
AU  - Hedenstierna,G
AU  - Jaber,S
AU  - Hiesmayr,M
AU  - Hollmann,MW
AU  - Mills,GH
AU  - Vidal,Melo MF
AU  - Pearse,RM
AU  - Putensen,C
AU  - Schmid,W
AU  - Severgnini,P
AU  - Wrigge,H
AU  - Cambronero,OD
AU  - Ball,L
AU  - de,Abreu MG
AU  - Pelosi,P
AU  - Schultz,MJ
AU  - LAS,VEGAS studyinvestigators
AU  - PROtective,VEntilation NETwork
AU  - Clinical,Trial Network of the European Society of Anaesthesiology
DO  - 10.1186/s12871-021-01268-y
PY  - 2021///
TI  - The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study.
T2  - BMC Anesthesiol
UR  - http://dx.doi.org/10.1186/s12871-021-01268-y
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33740885
VL  - 21
ER  -
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