Imperial College London
Ben Creagh-Brown

Ben Creagh-Brown

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

b.creagh-brown08

 
 
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Location

 

Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pugin:2021:10.1186/s13054-021-03576-8,
author = {Pugin, J and Daix, T and Pagani, J-L and Morri, D and Giacomucci, A and Dequin, P-F and Guitton, C and Que, Y-A and Zani, G and Brealey, D and Lepape, A and Creagh-Brown, B and Wyncoll, D and Silengo, D and Irincheeva, I and Girard, L and Rebeaud, F and Maerki, I and Eggimann, P and François, B},
doi = {10.1186/s13054-021-03576-8},
journal = {Crit Care},
title = {Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study.},
url = {http://dx.doi.org/10.1186/s13054-021-03576-8},
volume = {25},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The early recognition and management of sepsis improves outcomes. Biomarkers may help in identifying earlier sub-clinical signs of sepsis. We explored the potential of serial measurements of C-reactive protein (CRP), procalcitonin (PCT) and pancreatic stone protein (PSP) for the early recognition of sepsis in patients hospitalized in the intensive care unit (ICU). METHODS: This was a multicentric international prospective observational clinical study conducted in 14 ICUs in France, Switzerland, Italy, and the United Kingdom. Adult ICU patients at risk of nosocomial sepsis were included. A biomarker-blinded adjudication committee identified sepsis events and the days on which they began. The association of clinical sepsis diagnoses with the trajectories of PSP, CRP, and PCT in the 3 days preceding these diagnoses of sepsis were tested for markers of early sepsis detection. The performance of the biomarkers in sepsis diagnosis was assessed by receiver operating characteristic (ROC) analysis. RESULTS: Of the 243 patients included, 53 developed nosocomial sepsis after a median of 6 days (interquartile range, 3-8 days). Clinical sepsis diagnosis was associated with an increase in biomarkers value over the 3 days preceding this diagnosis [PSP (p = 0.003), PCT (p = 0.025) and CRP (p = 0.009)]. PSP started to increase 5 days before the clinical diagnosis of sepsis, PCT 3 and CRP 2 days, respectively. The area under the ROC curve at the time of clinical sepsis was similar for all markers (PSP, 0.75; CRP, 0.77; PCT, 0.75). CONCLUSIONS: While the diagnostic accuracy of PSP, CRP and PCT for sepsis were similar in this cohort, serial PSP measurement demonstrated an increase of this marker the days preceding the onset of signs necessary to clinical diagnose sepsis. This observation justifies further evaluation of the potential clinical benefit of serial PSP measurement in the management of critica
AU  - Pugin,J
AU  - Daix,T
AU  - Pagani,J-L
AU  - Morri,D
AU  - Giacomucci,A
AU  - Dequin,P-F
AU  - Guitton,C
AU  - Que,Y-A
AU  - Zani,G
AU  - Brealey,D
AU  - Lepape,A
AU  - Creagh-Brown,B
AU  - Wyncoll,D
AU  - Silengo,D
AU  - Irincheeva,I
AU  - Girard,L
AU  - Rebeaud,F
AU  - Maerki,I
AU  - Eggimann,P
AU  - François,B
DO  - 10.1186/s13054-021-03576-8
PY  - 2021///
TI  - Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study.
T2  - Crit Care
UR  - http://dx.doi.org/10.1186/s13054-021-03576-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33879189
VL  - 25
ER  -
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