Imperial College London
Ben Creagh-Brown

Ben Creagh-Brown

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

b.creagh-brown08

 
 
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Location

 

Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arvaniti:2022:10.1016/j.ijantimicag.2022.106591,
author = {Arvaniti, K and Dimopoulos, G and Antonelli, M and Blot, K and Creagh-Brown, B and Deschepper, M and de, Lange D and De, Waele J and Dikmen, Y and Eckmann, C and Einav, S and Francois, G and Fjeldsoee-Nielsen, H and Girardis, M and Jovanovic, B and Lindner, M and Koulenti, D and Labeau, S and Lipman, J and Lipovestky, F and Makikado, LDU and Maseda, E and Mikstacki, A and Montravers, P and Paiva, JA and Pereyra, C and Rello, J and Timsit, J-F and Tomescu, D and Vogelaers, D and Blot, S and Abdominal, Sepsis Study AbSeS Group on behalf of the Trials Group of the European Society of Intensive Care Medicine},
doi = {10.1016/j.ijantimicag.2022.106591},
journal = {Int J Antimicrob Agents},
title = {Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study.},
url = {http://dx.doi.org/10.1016/j.ijantimicag.2022.106591},
volume = {60},
year = {2022}
}
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TY  - JOUR
AB  - OBJECTIVE: To describe epidemiology and age-related mortality in critically ill older adults with intra-abdominal infection. METHODS: A secondary analysis was undertaken of a prospective, multi-national, observational study (Abdominal Sepsis Study, ClinicalTrials.gov #NCT03270345) including patients with intra-abdominal infection from 309 intensive care units (ICUs) in 42 countries between January and December 2016. Mortality was considered as ICU mortality, with a minimum of 28 days of observation when patients were discharged earlier. Relationships with mortality were assessed by logistic regression analysis. RESULTS: The cohort included 2337 patients. Four age groups were defined: middle-aged patients [reference category; 40-59 years; n=659 (28.2%)], young-old patients [60-69 years; n=622 (26.6%)], middle-old patients [70-79 years; n=667 (28.5%)] and very old patients [≥80 years; n=389 (16.6%)]. Secondary peritonitis was the predominant infection (68.7%) and was equally prevalent across age groups. Mortality increased with age: 20.9% in middle-aged patients, 30.5% in young-old patients, 31.2% in middle-old patients, and 44.7% in very old patients (P<0.001). Compared with middle-aged patients, young-old age [odds ratio (OR) 1.62, 95% confidence interval (CI) 1.21-2.17], middle-old age (OR 1.80, 95% CI 1.35-2.41) and very old age (OR 3.69, 95% CI 2.66-5.12) were independently associated with mortality. Other independent risk factors for mortality included late-onset hospital-acquired intra-abdominal infection, diffuse peritonitis, sepsis/septic shock, source control failure, liver disease, congestive heart failure, diabetes and malnutrition. CONCLUSIONS: For ICU patients with intra-abdominal infection, age >60 years was associated with mortality; patients aged ≥80 years had the worst prognosis. Comorbidities and overall disease severity further compromised survival. As all of these factors are non-modifiable, it remains unclear how to improve outcomes.
AU  - Arvaniti,K
AU  - Dimopoulos,G
AU  - Antonelli,M
AU  - Blot,K
AU  - Creagh-Brown,B
AU  - Deschepper,M
AU  - de,Lange D
AU  - De,Waele J
AU  - Dikmen,Y
AU  - Eckmann,C
AU  - Einav,S
AU  - Francois,G
AU  - Fjeldsoee-Nielsen,H
AU  - Girardis,M
AU  - Jovanovic,B
AU  - Lindner,M
AU  - Koulenti,D
AU  - Labeau,S
AU  - Lipman,J
AU  - Lipovestky,F
AU  - Makikado,LDU
AU  - Maseda,E
AU  - Mikstacki,A
AU  - Montravers,P
AU  - Paiva,JA
AU  - Pereyra,C
AU  - Rello,J
AU  - Timsit,J-F
AU  - Tomescu,D
AU  - Vogelaers,D
AU  - Blot,S
AU  - Abdominal,Sepsis Study AbSeS Group on behalf of the Trials Group of the European Society of Intensive Care Medicine
DO  - 10.1016/j.ijantimicag.2022.106591
PY  - 2022///
TI  - Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study.
T2  - Int J Antimicrob Agents
UR  - http://dx.doi.org/10.1016/j.ijantimicag.2022.106591
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35460850
VL  - 60
ER  -
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