Imperial College London
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Professor Brian Davies

Faculty of Engineering, Department of Mechanical Engineering

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 7200b.davies

 
 
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Location

 

706City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Parittotokkaporn:2011,
author = {Parittotokkaporn, T and Thomas, DG and Schneider, A and Huq, E and Davies, BL and Degenaar, P and Rodriguez, y Baena F},
journal = {World Neurosurgery},
pages = {569--576},
title = {Microtextured Surfaces for Deep-Brain Stimulation Electrodes: A Biologically Inspired Design to Reduce Lead Migration},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22120348},
volume = {77},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Hardware-related complications of deep brain stimulation (DBS) surgery have been reported with adverse effects in postoperative electrode migration. We report that the addition of microtextured features to the surface of a DBS-like probe can minimize the extent of electrode migration in ex vivo porcine brain. METHODS: A DBS lead and microtextured strips, mounted with a fiberoptic displacement sensor, were embedded 15-mm deep inside a cadaveric porcine brain through holes on the skull. The local displacement of brain tissue surrounding each strip was detected along the direction of insertion by the optical sensor while the porcine head simulated brain shift during rotation between supine and upright postures. RESULTS: The triangular toothed strip with protruding height of 250 mum enabled a better grip of the surrounding brain tissue than standard DBS lead, minimizing local brain displacement to 77 mum versus 326 mum respectively, when the porcine head was shifted from the supine to the upright position as the result of gravity. In addition, brain tissue damage resulting from the removal of toothed strips exhibited less-extensive tissue disruption, attributable to the microtextured surface. CONCLUSIONS: These preliminary results show that microtextured strips embedded into cadaveric porcine brain produce an anchoring effect on local tissue during brain shift, suggesting a way to reduce DBS lead migration without additional tissue damage beyond the strip geometry.
AU  - Parittotokkaporn,T
AU  - Thomas,DG
AU  - Schneider,A
AU  - Huq,E
AU  - Davies,BL
AU  - Degenaar,P
AU  - Rodriguez,y Baena F
EP  - 576
PY  - 2011///
SN  - 1878-8750
SP  - 569
TI  - Microtextured Surfaces for Deep-Brain Stimulation Electrodes: A Biologically Inspired Design to Reduce Lead Migration
T2  - World Neurosurgery
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22120348
VL  - 77
ER  -
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