Imperial College London
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Dr Ben Glocker

Faculty of Engineering, Department of Computing

Professor in Machine Learning for Imaging
 
 
 
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Contact

 

+44 (0)20 7594 8334b.glocker Website CV

 
 
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Location

 

377Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mathieu:2020:10.1089/neu.2019.6911,
author = {Mathieu, F and Güting, H and Gravesteijn, B and Monteiro, M and Glocker, B and Kornaropoulos, EN and Kamnistas, K and Robertson, CS and Levin, H and Whitehouse, DP and Das, T and Lingsma, HF and Maegele, M and Newcombe, VFJ and Menon, DK and Collaborative, European NeuroTrauma Effectiveness Research in Traumatic Brain Injury CENTER-TBI Investigators and Participants},
doi = {10.1089/neu.2019.6911},
journal = {J Neurotrauma},
pages = {2069--2080},
title = {Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury: A CENTER-TBI Propensity-Matched Cohort Analysis.},
url = {http://dx.doi.org/10.1089/neu.2019.6911},
volume = {37},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An increasing number of elderly patients are being affected by traumatic brain injury (TBI) and a significant proportion are on pre-hospital antithrombotic therapy for cardio- or cerebrovascular indications. We have quantified the impact of antiplatelet/anticoagulant (APAC) agents on radiological lesion progression in acute TBI, using a novel, semi-automated approach to volumetric lesion measurement, and explored the impact of use on clinical outcomes in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. We used a 1:1 propensity-matched cohort design, matching controls to APAC users based on demographics, baseline clinical status, pre-injury comorbidities, and injury severity. Subjects were selected from a pool of patients enrolled in CENTER-TBI with computed tomography (CT) scan at admission and repeated within 7 days of injury. We calculated absolute changes in volume of intraparenchymal, extra-axial, intraventricular, and total intracranial hemorrhage (ICH) between scans, and compared volume of hemorrhagic progression, proportion of patients with significant degree of progression (>25% of initial volume), proportion with new ICH on follow-up CT, as well as clinical course and outcomes. A total of 316 patients were included (158 APAC users; 158 controls). The mean volume of progression was significantly higher in the APAC group for extra-axial (3.1 vs. 1.3 mL, p = 0.01), but not intraparenchymal (3.8 vs. 4.6 mL, p = 0.65), intraventricular (0.2 vs. 0.0 mL, p = 0.79), or total intracranial hemorrhage (ICH; 7.0 vs. 6.0 mL, p = 0.08). More patients had significant hemorrhage growth (54.1 vs. 37.0%, p = 0.003) and delayed ICH (4 of 18 vs. none; p = 0.04) in the APAC group compared with controls, but this was not associated with differences in length of stay (LOS), rates of neurosurgical intervention
AU  - Mathieu,F
AU  - Güting,H
AU  - Gravesteijn,B
AU  - Monteiro,M
AU  - Glocker,B
AU  - Kornaropoulos,EN
AU  - Kamnistas,K
AU  - Robertson,CS
AU  - Levin,H
AU  - Whitehouse,DP
AU  - Das,T
AU  - Lingsma,HF
AU  - Maegele,M
AU  - Newcombe,VFJ
AU  - Menon,DK
AU  - Collaborative,European NeuroTrauma Effectiveness Research in Traumatic Brain Injury CENTER-TBI Investigators and Participants
DO  - 10.1089/neu.2019.6911
EP  - 2080
PY  - 2020///
SP  - 2069
TI  - Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury: A CENTER-TBI Propensity-Matched Cohort Analysis.
T2  - J Neurotrauma
UR  - http://dx.doi.org/10.1089/neu.2019.6911
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32312149
VL  - 37
ER  -
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