Imperial College London
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DrBrianHalliday

Faculty of Medicine, National Heart & Lung Institute

Sr Lecturer Cardiomyopathy Cardiovascular Magnetic Resonance
 
 
 
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Contact

 

b.halliday

 
 
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Location

 

Cardiovascular MR UnitRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tayal:2022,
author = {Tayal, U and gregson, J and Buchan, R and Whiffin, N and Halliday, B and Lota, A and Roberts, A and Baksi, A and Voges, I and Jarman, J and Baruah, R and Frenneaux, M and Cleland, J and Barton, P and Pennell, D and Ware, J and Cook, S and Prasad, S},
journal = {Heart},
pages = {619--625},
title = {Moderate excess alcohol consumption and adverse cardiac remodelling in dilated cardiomyopathy},
url = {https://heart.bmj.com/content/108/8/619},
volume = {108},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective The effect of moderate excess alcohol consumption is widely debated and has not been well defined in dilated cardiomyopathy (DCM). There is need for a greater evidence base to help advise patients. We sought to evaluate the effect of moderate excess alcohol consumption on cardiovascular structure, function and outcomes in DCM. Methods Prospective longitudinal observational cohort study. Patients with DCM (n=604) were evaluated for a history of moderate excess alcohol consumption (UK government guidelines; >14 units/week for women, >21 units/week for men) at cohort enrollment, had cardiovascular magnetic resonance and were followed up for the composite endpoint of cardiovascular death, heart failure and arrhythmic events. Patients meeting criteria for alcoholic cardiomyopathy were not recruited. ResultsDCM patients with a history of moderate excess alcohol consumption (n=98, 16%) had lower biventricular function and increased chamber dilatation of the left ventricle, right ventricle and left atrium, as well as increased left ventricular hypertrophy compared to patients without moderate alcohol consumption. They were more likely to be male (alcohol excess group– n =92, 94% vs n =306, 61%, p=<0.001). After adjustment for biological sex, moderate excess alcohol was not associated with adverse cardiac structure. There was no difference in mid-wall myocardial fibrosis between groups. Prior moderate excess alcohol consumption did not affect prognosis (HR 1.29, 0.73 to 2.26, p=0.38) during median follow up of 3.9 years. ConclusionDilated cardiomyopathy patients with moderate excess alcohol consumption have adverse cardiac structure and function at presentation but this is largely due to biological sex. Alcohol may contribute to sex-specific phenotypic differences in DCM. These findings help to inform lifestyle discussions for patients with dilated cardiomyopathy.
AU  - Tayal,U
AU  - gregson,J
AU  - Buchan,R
AU  - Whiffin,N
AU  - Halliday,B
AU  - Lota,A
AU  - Roberts,A
AU  - Baksi,A
AU  - Voges,I
AU  - Jarman,J
AU  - Baruah,R
AU  - Frenneaux,M
AU  - Cleland,J
AU  - Barton,P
AU  - Pennell,D
AU  - Ware,J
AU  - Cook,S
AU  - Prasad,S
EP  - 625
PY  - 2022///
SN  - 1355-6037
SP  - 619
TI  - Moderate excess alcohol consumption and adverse cardiac remodelling in dilated cardiomyopathy
T2  - Heart
UR  - https://heart.bmj.com/content/108/8/619
UR  - http://hdl.handle.net/10044/1/90635
VL  - 108
ER  -
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