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@article{Thery:2018:10.1080/20013078.2018.1535750,
author = {Thery, C and Witwer, KW and Aikawa, E and Jose, Alcaraz M and Anderson, JD and Andriantsitohaina, R and Antoniou, A and Arab, T and Archer, F and Atkin-Smith, GK and Ayre, DC and Bach, J-M and Bachurski, D and Baharvand, H and Balaj, L and Baldacchino, S and Bauer, NN and Baxter, AA and Bebawy, M and Beckham, C and Zavec, AB and Benmoussa, A and Berardi, AC and Bergese, P and Bielska, E and Blenkiron, C and Bobis-Wozowicz, S and Boilard, E and Boireau, W and Bongiovanni, A and Borras, FE and Bosch, S and Boulanger, CM and Breakefield, X and Breglio, AM and Brennan, MA and Brigstock, DR and Brisson, A and Broekman, MLD and Bromberg, JF and Bryl-Gorecka, P and Buch, S and Buck, AH and Burger, D and Busatto, S and Buschmann, D and Bussolati, B and Buzas, E and Byrd, JB and Camussi, G and Carter, DRF and Caruso, S and Chamley, LW and Chang, Y-T and Chen, C and Chen, S and Cheng, L and Chin, AR and Clayton, A and Clerici, SP and Cocks, A and Cocucci, E and Coffey, RJ and Cordeiro-da-Silva, },
doi = {10.1080/20013078.2018.1535750},
journal = {Journal of Extracellular Vesicles},
title = {Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines},
url = {http://dx.doi.org/10.1080/20013078.2018.1535750},
volume = {7},
year = {2018}
}

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TY  - JOUR
AB  - The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
AU  - Thery,C
AU  - Witwer,KW
AU  - Aikawa,E
AU  - Jose,Alcaraz M
AU  - Anderson,JD
AU  - Andriantsitohaina,R
AU  - Antoniou,A
AU  - Arab,T
AU  - Archer,F
AU  - Atkin-Smith,GK
AU  - Ayre,DC
AU  - Bach,J-M
AU  - Bachurski,D
AU  - Baharvand,H
AU  - Balaj,L
AU  - Baldacchino,S
AU  - Bauer,NN
AU  - Baxter,AA
AU  - Bebawy,M
AU  - Beckham,C
AU  - Zavec,AB
AU  - Benmoussa,A
AU  - Berardi,AC
AU  - Bergese,P
AU  - Bielska,E
AU  - Blenkiron,C
AU  - Bobis-Wozowicz,S
AU  - Boilard,E
AU  - Boireau,W
AU  - Bongiovanni,A
AU  - Borras,FE
AU  - Bosch,S
AU  - Boulanger,CM
AU  - Breakefield,X
AU  - Breglio,AM
AU  - Brennan,MA
AU  - Brigstock,DR
AU  - Brisson,A
AU  - Broekman,MLD
AU  - Bromberg,JF
AU  - Bryl-Gorecka,P
AU  - Buch,S
AU  - Buck,AH
AU  - Burger,D
AU  - Busatto,S
AU  - Buschmann,D
AU  - Bussolati,B
AU  - Buzas,E
AU  - Byrd,JB
AU  - Camussi,G
AU  - Carter,DRF
AU  - Caruso,S
AU  - Chamley,LW
AU  - Chang,Y-T
AU  - Chen,C
AU  - Chen,S
AU  - Cheng,L
AU  - Chin,AR
AU  - Clayton,A
AU  - Clerici,SP
AU  - Cocks,A
AU  - Cocucci,E
AU  - Coffey,RJ
AU  - Cordeiro-da-Silva,A
AU  - Couch,Y
AU  - Coumans,FAW
AU  - Coyle,B
AU  - Crescitelli,R
AU  - Criado,MF
AU  - D'Souza-Schorey,C
AU  - Das,S
AU  - Chaudhuri,AD
AU  - de,Candia P
AU  - De,Santana Junior EF
AU  - De,Wever O
AU  - del,Portillo HA
AU  - Demaret,T
AU  - Deville,S
AU  - Devitt,A
AU  - Dhondt,B
AU  - Di,Vizio D
AU  - Dieterich,LC
AU  - Dolo,V
AU  - Dominguez,Rubio AP
AU  - Dominici,M
AU  - Dourado,MR
AU  - Driedonks,TAP
AU  - Duarte,F
AU  - Duncan,HM
AU  - Eichenberger,RM
AU  - Ekstrom,K
AU  - Andaloussi,SEL
AU  - Elie-Caille,C
AU  - Erdbrugger,U
AU  - Falcon-Perez,JM
AU  - Fatima,F
AU  - Fish,JE
AU  - Flores-Bellver,M
AU  - Forsonits,A
AU  - Frelet-Barrand,A
AU  - Fricke,F
AU  - Fuhrmann,G
AU  - Gabrielsson,S
AU  - Gamez-Valero,A
AU  - Gardiner,C
AU  - Gaertner,K
AU  - Gaudin,R
AU  - Gho,YS
AU  - Giebel,B
AU  - Gilbert,C
AU  - Gimona,M
AU  - Giusti,I
AU  - Goberdhan,DC
AU  - Goergens,A
AU  - Gorski,SM
AU  - Greening,DW
AU  - Gross,JC
AU  - Gualerzi,A
AU  - Gupta,GN
AU  - Gustafson,D
AU  - Handberg,A
AU  - Haraszti,RA
AU  - Harrison,P
AU  - Hegyesi,H
AU  - Hendrix,A
AU  - Hill,AF
AU  - Hochberg,FH
AU  - Hoffmann,KF
AU  - Holder,B
AU  - Holthofer,H
AU  - Hosseinkhani,B
AU  - Hu,G
AU  - Huang,Y
AU  - Huber,V
AU  - Hunt,S
AU  - Ibrahim,AG-E
AU  - Ikezu,T
AU  - Inal,JM
AU  - Isin,M
AU  - Ivanova,A
AU  - Jackson,HK
AU  - Jacobsen,S
AU  - Jay,SM
AU  - Jayachandran,M
AU  - Jenster,G
AU  - Jiang,L
AU  - Johnson,SM
AU  - Jones,JC
AU  - Jong,A
AU  - Jovanovic-Talisman,T
AU  - Jung,S
AU  - Kalluri,R
AU  - Kano,S-I
AU  - Kaur,S
AU  - Kawamura,Y
AU  - Keller,ET
AU  - Khamari,D
AU  - Khomyakova,E
AU  - Khvorova,A
AU  - Kierulf,P
AU  - Kim,KP
AU  - Kislinger,T
AU  - Klingeborn,M
AU  - Klinke,DJ
AU  - Kornek,M
AU  - Kosanovic,MM
AU  - Kovacs,AF
AU  - Kraemer-Albers,E-M
DO  - 10.1080/20013078.2018.1535750
PY  - 2018///
SN  - 2001-3078
TI  - Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
T2  - Journal of Extracellular Vesicles
UR  - http://dx.doi.org/10.1080/20013078.2018.1535750
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000452068900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/66229
VL  - 7
ER  -

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