Imperial College London
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Dr. Beth Holder

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Maternal and Fetal Health
 
 
 
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Contact

 

+44 (0)20 7594 1773b.holder Website

 
 
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Location

 

3 008Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rice:2019:10.1111/cei.13275,
author = {Rice, T and Diavatopoulos, D and Smits, G and van, Gageldonk P and Berbers, G and van, der Klis F and Vamvakas, G and Donaldson, B and Bouqueau, M and Holder, B and Kampmann, B},
doi = {10.1111/cei.13275},
journal = {Clinical and Experimental Immunology},
pages = {1--10},
title = {Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK},
url = {http://dx.doi.org/10.1111/cei.13275},
volume = {197},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The maternal Tdap (tetanus, diphtheria and acellular pertussis) vaccination program in the UK has successfully reduced cases of pertussis in young infants. In addition to prevention of pertussis cases, it is also important to investigate persistence of maternal antibody during infancy and possible interference of maternal antibodies with infant responses to vaccines. We recruited motherinfant pairs from vaccinated and unvaccinated pregnancies and measured concentrations of IgG against pertussis toxin (PTx), filamentous hemagglutinin (FHA), pertactin (Prn), diphtheria toxin (DTx), tetanus toxoid (TTx) Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae in mothers and infants at birth, and in infants at 7 weeks and at 5 months. 31 motherinfant pairs were tested. Tdapvaccinated women had significantly higher antibody against Tdap antigens, compared to unvaccinated women (DTx p=0.01; PTx, FHA, Prn and TTx p<0.001). All antibodies were actively transferred to the infants (transfer ratio >1) with higher transfer of DTx (P=0.04) and TTx (P=0.02) antibody in Tdapvaccinated pregnancies compared to unvaccinated. Infants from Tdapvaccinated pregnancies had significantly elevated antibodies to all antigens at birth (p<0.001) and at 7 weeks (FHA, Prn, TTx p<0.001; DTx p=0.01; PTx p=0.004) compared to infants from unvaccinated pregnancies. Infants from Tdapvaccinated and unvaccinated pregnancies had comparable antibody concentrations following primary pertussis immunization (PTx p=0.77; FHA p=0.58; Prn p=0.60; DTx p=0.09; TTx p=0.88). These results support maternal immunisation as a method of protecting vulnerable infants during their first weeks of life.
AU  - Rice,T
AU  - Diavatopoulos,D
AU  - Smits,G
AU  - van,Gageldonk P
AU  - Berbers,G
AU  - van,der Klis F
AU  - Vamvakas,G
AU  - Donaldson,B
AU  - Bouqueau,M
AU  - Holder,B
AU  - Kampmann,B
DO  - 10.1111/cei.13275
EP  - 10
PY  - 2019///
SN  - 1365-2249
SP  - 1
TI  - Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK
T2  - Clinical and Experimental Immunology
UR  - http://dx.doi.org/10.1111/cei.13275
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/cei.13275
UR  - http://hdl.handle.net/10044/1/67450
VL  - 197
ER  -
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