Imperial College London
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Dr. Beth Holder

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Maternal and Fetal Health
 
 
 
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Contact

 

+44 (0)20 7594 1773b.holder Website

 
 
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Location

 

3 008Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clements:2020:10.3389/fimmu.2020.01920,
author = {Clements, T and Rice, T and Vamvakas, G and Barnett, S and Barnes, M and Donaldson, B and Christine, J and Kampmann, B and Holder, E},
doi = {10.3389/fimmu.2020.01920},
journal = {Frontiers in Immunology},
pages = {1--17},
title = {Update on trans-placental transfer of IgG subclasses: impact of maternal and fetal factors},
url = {http://dx.doi.org/10.3389/fimmu.2020.01920},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Transplacental antibody transfer from mother to fetus provides protection from infection in the first weeks of life, and the four different subclasses of IgG (IgG1, IgG2, IgG3, and IgG4) have diverse roles in protection against infection. In this study, we evaluated concentrations and transplacental transfer ratios of the IgG subclasses in a healthy UK-based cohort of mother-cord pairs, and investigated associations with maternal, obstetric, and fetal factors. In agreement with previous studies, we found a strong association between maternal and cord IgG for all subclasses. We report a transfer efficiency hierarchy of IgG1>IgG3>IgG4=IgG2 in our study population, and our review of the literature demonstrates that there is no consensus in the hierarchy of subclass transfer, despite the commonly made statement that the order is IgG1>IgG4>IgG3>IgG2. We report additional data regarding negative associations between elevated maternal IgG concentrations and maternal/cord transfer ratios, finding an effect on IgG1, IgG2, and IgG3 subclasses. Levels of IgG subclasses were the same between venous and arterial blood samples from the umbilical cord, but there was a significantly higher level of total IgG in arterial blood. We found no correlation between placental FcRn protein levels and IgG transfer in our cohort, suggesting that IgG is the main determinant of observed differences in transplacental transfer ratios at term. Neonatal IgG1 and IgG4 levels were increased with later gestation at delivery, independent of any increase in transplacental transfer, indicating that the benefit of later gestation is through accumulation of these subclasses in the fetus. Neonatal IgG2 levels and transfer ratios were reduced in rhesus-negative pregnancies, suggesting that administered anti-D antibodies may compete for transplacental transfer of this subclass. Maternal influenza vaccination resulted in elevated maternal and neonatal levels of IgG4, whereas maternal Tdap vaccin
AU  - Clements,T
AU  - Rice,T
AU  - Vamvakas,G
AU  - Barnett,S
AU  - Barnes,M
AU  - Donaldson,B
AU  - Christine,J
AU  - Kampmann,B
AU  - Holder,E
DO  - 10.3389/fimmu.2020.01920
EP  - 17
PY  - 2020///
SN  - 1664-3224
SP  - 1
TI  - Update on trans-placental transfer of IgG subclasses: impact of maternal and fetal factors
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2020.01920
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2020.01920/full#h1
UR  - http://hdl.handle.net/10044/1/82403
VL  - 11
ER  -
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