Imperial College London
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Dr. Beth Holder

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Maternal and Fetal Health
 
 
 
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Contact

 

+44 (0)20 7594 1773b.holder Website

 
 
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Location

 

3 008Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pantazi:2022:10.1016/j.isci.2022.105653,
author = {Pantazi, P and Kaforou, M and Tang, Z and Abrahams, VM and McArdle, A and Guller, S and Holder, B},
doi = {10.1016/j.isci.2022.105653},
journal = {iScience},
title = {Placental macrophage responses to viral and bacterial ligands and the influence of fetal sex},
url = {http://dx.doi.org/10.1016/j.isci.2022.105653},
volume = {25},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bacterial and viral infections of the placenta are associated with inflammation and adverse pregnancy outcomes. Hofbauer cells (HBCs) are fetal-origin macrophages in the placenta, proposed to protect the fetus from vertical pathogen transmission. We performed quantitative proteomics on term HBCs under resting conditions and following exposure to bacterial and viral pathogen-associated molecular patterns (PAMPs), and investigated the contribution of fetal sex. Resting HBCs expressed proteins pertinent to macrophage function, including chemokines, cytokines, Toll-like receptors, and major histocompatibility complex class I and II molecules. HBCs mounted divergent responses to bacterial versus viral PAMPs but exhibited protein expression changes suggestive of a more pro-inflammatory phenotype. A comparison between male and female HBCs showed that the latter mounted a stronger and wider response. Here, we provide a comprehensive understanding of the sex-dependent responses of placental macrophages to infectious triggers, which were primarily associated with lipid metabolism in males and cytoskeleton organization in females.
AU  - Pantazi,P
AU  - Kaforou,M
AU  - Tang,Z
AU  - Abrahams,VM
AU  - McArdle,A
AU  - Guller,S
AU  - Holder,B
DO  - 10.1016/j.isci.2022.105653
PY  - 2022///
SN  - 2589-0042
TI  - Placental macrophage responses to viral and bacterial ligands and the influence of fetal sex
T2  - iScience
UR  - http://dx.doi.org/10.1016/j.isci.2022.105653
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000920775500005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.sciencedirect.com/science/article/pii/S2589004222019253
UR  - http://hdl.handle.net/10044/1/109784
VL  - 25
ER  -
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