Imperial College London

Dr. Beth Holder

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Lecturer in Maternal and Fetal Health
 
 
 
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Contact

 

+44 (0)20 7594 1773b.holder Website

 
 
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Location

 

3 008Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

MatImms

The MatImms study is a study into the impact of maternal pertussis and flu vaccination on neonatal and early-life immune responses. We are recruiting both vaccinated and unvaccinated mothers and collecting maternal and infant blood samples. We are using these samples to investigate both antibody and cell-mediated immune responses to vaccination, and its impact on responses to subsequent vaccinations in the infant.

Trans-placental exosome transfer

show research

Beth's primary research focus is invesigating the bi-directional trafficking of EVs between the mother and the feto-placental unit. Current research has previously focused on trafficking from the placenta to the mother. Beth has recently published the first demonstration of trafficking of EVs from immune cells to the placenta. This is also the first demonstration of uptake of heterologous EVs by the human placenta. This study demonstrated that uptake occurs by clathrin-mediated endocytosis, and induces the release of placental pro- and anti-inflammtory cytokines. Current and future work is continuing this research in more detail.

Collaborators

Dr. Lynda Harris, The University of Manchester, 2014

Dr. Paul Brownbill, The University of Manchester, 2014

Dr. Karen Forbes, The University of Manchester

Guest Lectures

Physiology Congress, Aberdeen, UK., 2019

Expert Review Meeting on Maternal Immunisation, PRERNA/WHO-TDR, 2018

Liverpool University Exosome Workshop, The University of Liverpool, 2016

Research Student Supervision

Rice,T, Impact of maternal pertussis vaccination on the development of the innate and adaptive infant immune system’